Manchester variant

[littlebillie]

www.manchestereveningnews.co.uk/news/greater-manchester-news/manchester-areas-residents-workers-should-19796809

Who fucking cares.

Chips and gravy on the other hand......

@TheJerkStore

Which the vaccines are probably less effective against.

Do you have any evidence for this?

There are quite a few studies showing that various vaccines are less effective against the SA and Brazilian vaccine, either in efficacy trials or when looking at the ability of antibodies in vaccinated individuals to neutralise virus in lab tests. I'm not going to list them all here. Obviously there are no studies for the "mutated kent" strains. I was referring to the E484K mutation in the SA and Brazil variants which is what is seen in the Manchester and Bristol variants of the Kent strain.

Maybe I should have said possibly rather than probably but there are quite a few studies suggesting the vaccines are less effective against this mutation and the pharma companies themselves admit it.

@JS87

Which the vaccines are probably less effective against.

Do you mean possibly? How can you know that they are probably less effective. Do you work in vaccine research?

So JS87, thats a 'no' to proper evidence then? Just another poster making claims to scare people. And people wonder why the gullible and stupid turn to qAnon and that ilk.

@userxx

Who fucking cares.

Chips and gravy on the other hand......

My thoughts exactly

It’s not scare mongering to say that a variant with a mutation in the same section of the gene as the South African variant may be quite likely to share some of the same properties as that variant.

Unfortunately.

The media and gov are playing us for fools.
No wonder we have it worse than other places.
Keeping us on our toes and finding new ways to eradicate our freedoms.

@titchy

I think it's because it makes you call everyone 'our kid' and put gravy on your chips.

Bloody brilliant

I miss proper northern chip shop gravy.

totally ignores point of the thread

There is one very small in vitro study on the emergence of E484K on B.1.1.7 reducing neutralisation by vaccine sera (Pfizer vaccine, single dose). The link to the preprint is here (this is the study mentioned in the BMJ article/ discussion link above).
mobile.twitter.com/GuptaR_lab/status/1357294122743300099

You're all missing the point. It's not just chips and gravy we eat. It has to be chips, peas and gravy with a barm.

Actually it's chips, gravy and mushy peas, why do they eat them dry down south?
Give me something moist with my chips.

I've never done mushy peas on a barm, chips and gravy yes, never with peas. I'm going to have to give it a go.

It is a bit concerning that the Kent variant has developed some of the mutation that allows the SA and MBrazil/Manaus variant to partially evade immune systems. Clearly the government want to keep a lid on it which is why they are surge testing as they already have in other areas where it has been found like Southport etc

Clearly there is not yet iron cast evidence of its ability to evade vaccines etc as it hasn't spread very much and most people haven't been vaccinated so has no advantage over the ordinary Kent strain yet but this will change as more and more people are vaccinated so it needs to be contained until booster jabs against it are developed for the autumn.

Not sure why people dismiss the pp as scaremongering because we don't want people in those areas to be reluctant to take tests or dismiss the need for them as just scaremongering

Please don't ruin my chips and gravy with mushy peas!

It is a bit unnerving that it seems to be mutating in exactly the same way in different locations around the world, seemingly independently. I'm no epidemiologist though and am always interested to hear from those in the know.

One thing I can say with certainty: I'm fed up to the back teeth with the word "scaremongering".

There is plenty of evidence out there. I just don't have time to find it for everyone.
There is the J&J phase III trial, there is a study from Cambridge university, the AZ study in the news yesterday, a study from Pfizer in the news yesterday.
www.cam.ac.uk/research/news/pfizer-biontech-vaccine-likely-to-be-effective-against-b117-strain-of-sars-cov-2
However, whilst I am being slated for not listing all the data that is out there nobody is slating the posters who obviously didn't read the article which the OP gave a link for. I mainly wanted to say that it wasn't about the "kent variant" but about the "kent variant with an E484K mutation".
Actually I am an immunologist so I have read a lot of the data coming out and do understand it.

I didn't specify mushy as I didn't realise chip shops did anything else! What's the dry peas? Like frozen peas?

[quote CoffeeandCroissant]There is one very small in vitro study on the emergence of E484K on B.1.1.7 reducing neutralisation by vaccine sera (Pfizer vaccine, single dose). The link to the preprint is here (this is the study mentioned in the BMJ article/ discussion link above).
mobile.twitter.com/GuptaR_lab/status/1357294122743300099[/quote]
And one here on the 6 fold reduction in neutralising activity of sera after the moderna vaccine.
investors.modernatx.com/news-releases/news-release-details/moderna-covid-19-vaccine-retains-neutralizing-activity-against

This is the J&J one where efficacy was reduced from 72% in USA to 57% in SA.

I think most scientists are pretty clear that the vaccines will probably be less effective against the SA variant. However, what is not clear is HOW less effective they will be. It may only be 5%, it may be 60%. We shall have to wait and see.

We DO NOT put mushy beas in our barms. Can you please not spread these lies, MN is already anti 'the North'

We moved to East Anglia many years ago, back in Manc now, but we went to the chippy whilst moving in, and I asked for chips gravy and mushy peas for me, and chips and babbies yed for dh.
The bloke says "You're not from round ere are you?

We put meat and potato pie on a barm where I live.
It's a kebab.

@Devlesko

We moved to East Anglia many years ago, back in Manc now, but we went to the chippy whilst moving in, and I asked for chips gravy and mushy peas for me, and chips and babbies yed for dh. The bloke says "You're not from round ere are you?

Is "unfortunately" the new "sadly" or "I'm afraid"?

@Devlesko I'm guessing Wigan :)