There is another thing about London, it got hit hard the first time. So most people seem to perceive the restrictions of Tier 2/3 as being protective rather than punishment. Whereas in some parts of the UK (as so frequently evidenced on mumsnet) it's clearly seen as punishment.
Generally rule-breaking starts the chain of cases increasing. Once cases in the community reach a certain level at MSOA level though, there has to be more spread, and quickly, between households, workers, university / FE/ older secondary schools - all those who can't isolate and are around so many contacts that they must meet someone with the virus. Less compliant areas get hit harder, but it spreads from specific MSOAs first. So I think it would surely be possible to devise a simple formula now that has:
weekly rolling case volume avg residents per household % working outside the home * (11 - deprivation score) = N,
Where any number above say 2000 needs urgent action. I'm amazed nobody seems to have tried to model it to identify the risk number yet.