I am soo frustrated I was on the shot for 4 1/2 years and I never once thought that I had a problem with it. I started getting kidney stones about a year after i started the shot and i now realized that the only time after my kidney stones started that i was kidney stone free is when i wasnt on the shot. I stopped the shot twice. Once about 2 years ago for 3months and for those 3 months there were no traces of stones in my kidney. i have also stopped taking the shot this year and now for the past 5 months I am again stone free. soo i have a question. If depo can help stop the production of kidney stones can it cause them too? please help me figure this out. Im so confused.