TTC or pregnancy on prednisolone or similar part 11

[Buzzybee123]

This is a positive thread for all those diagnosed with High or Very High NK Cells and looking to start TTC or already pregnant on Prednisolone and/or Intralipid treatment.

Newcomers very much welcome!

I'm v anxious - not sure if it's the steroids or the situation. Not conducive to calmness really!

So sorry to hear about the spotting getting heavier team, but must be due to the other sac miscarrying - to be expected, as they said? Don't know about the effect of steroids but think it's totally normal to feel anxious in the circs! Could you go for a scan before the 31st to set your mind at rest? Bloating normal too, at 7 weeks I always look as if I'm in second trimester!

When is your scan? It's this week isn't it? I work in an office and I'm surrounded by pregnant girls rubbing their bellies and looking happy!

I'm so envious of that! And I'm sad I can't enjoy one of the happiest times of our lives!

dooms thursday. It's going to be a long week.

No no! Stay positive!

I always look massive when on steroids. With awful indigestion and bloating. My nan-in-law takes them for polymyalgia and she looks 9 months pregnant, seriously. They certainly make some people very anxious, although I am always Anxiety Girl anyway - I leap to the worst conclusion in a single bound! - so I don't think they make much difference to me. A friend of mine takes them for Crohns, as a suppository, and they make her extremely anxious, so she only uses them as the last resort. She says it's a constant feeling of nameless dread. I assume the people who find them anxiety-provoking are the same ones who get predsomnia too?

Ahhh I didn't put the two together anxiety and the steroids in first trimester. I have just got my Chromosonal testing results back from my last ERPC. It was trisomy 16. That has thrown me a bit. Out of my 6 losses the first was a blighted ovum and natural mc, second got to 12 weeks and was trisomy 13 ERPC, third ERPC but inconclusive, 4th was 2 CGH tested embryos, 5th a chemical and 6th ERPC trisomy 16. What to make of all this? The 4th, 5th and 6th losses were on etc treatment ?

Gosh, Duggs, it is shocking to receive this news, isn't it? But also good to know that the treatment was working; from what I've just googled with trisomy 16 a baby would never have survived?
It does seem to suggest then that IVF of some kind is the way forward for you, especially since you don't have an issue of reduced ovarian reserve. My last ERPC showed trisomy 21 and I found it both shocking but also good to get closure, and to know the problem was banal and commonplace and not something obscure I hadn't yet researched online. I was relieved that my body obviously knows what to do when there is a problem too and that it didn't go any further, even though I would never had a termination for Downs.
What does your DH think?

duggs where did you get the CGH done? And did they give you a reason for that mc?

You may find you kind of 're-grieve' as well; I got my results so long after the ERPC that that happened to me, when I had felt on top of things, especially as we found out the sex too.
It's good that you've got an answer though.
Big hugs x

Thinking of free today.

Now have another scan booked with a specialist on Friday (also feeling it will be a long week baking)

Blood results showed two cancer markers were normal, one was raised but (with everything crossed) this could be skewed by effects of pregnancy apparently. I will find out more on Friday.

So confused by everything this time. Nothing is clear cut, the bleeding and pain are intermittent but am not working this week and on self imposed bed-rest so perhaps delaying the inevitable? Can this happen? It's always been quick before.

Specialist very wary about the holiday, looks like we may have to cancel. Sad for DH and DS but I am so anxious at the moment, apparently the cyst could twist and it just seems risky. My last holiday I spent a week in hospital in the Caribbean, I vowed I'd never travel again...!

duggs hard to explain, your history needs one of your systematic lists I think I don't know if the treatment works for everyone or every time. It is so successful when it does but I think some of us may have other issues. If only there was money for the research, I'd guinea-pig myself in a heartbeat.

Gosh Duggs surely now you could get that ivf testing they do on the NHS rather than privately.

I hope that will be a possibility!
X

Sorry crossed posts, must learn to refresh page.

duggs excuse ignorance but the CGH tested embryos were first IVF but not on NHS right? And were you on the works then, hyrdroxy etc? Did anyone give you a theory about those...?

Hi guys... Well the ivf we did march 2012 they put back 2 chromosonally normal embryos and I was on intrallipids and 40 mg pred -no hydroxy back then.... There was no reason they could give as was v early. We had a third chromosonally normal embryo and this was put back in September last year but I didn't get pregnant from that it threw us a bit tbh as to what to do next.

I think kittens had a few Chromosonal mc .... Did you too sue?
Thinking of free and sue and pebbles and hope things work out for Fridays scan scooter x

duggs do you mind me asking at which clinic you had the CGH testing done?

London women's clinic march 2012. I had 19 eggs retrieved, 17 were viable enough to fertilise. 100% were fertilised successfully with ICSI (you need ICSI with CGH testing) - 13 were left on day 2 by day 3 only 4 were left and these 4 were tested at Oxford Reprogenics lab. 2 were put back and 1 frozen. I got a positive pt but mc week 5 despite being on 40mg pred and intrallipids. No hydroxy. 3rd embryo transferred last September and no pregnancy test. Of the 4 embryos that looked normal 1 was very abnormal. Looks like almost 2 yrs later we will be doing the same thing. Most clinics offer it now I believe!

I don't know if my m/cs were down to chromosome probs as I never had them tested, had my first and third as an Erpc, the rest were expectant miscarriage. Normally everything has come away so not enough left for testing once I have had a scan at Epu. We had scarlet tested but the kidney probs were a one off and not likely to happen again. It will be interesting to see whether the last one had a chromosome prob.

duggs its scary that out of 17 eggs only 3 were the right quality. If you had conceived those 14 in a row they would have all ended in a miscarriage. You are fortunate that you can get a lot of eggs so that there are so many to play with. I wish I was in that position as I would be lucky to get 3 or 4 eggs! It concerns me that I could miscarry 14 or more in a row before I find the elusive egg but I don't have an alternative as wouldn't be able to go for cgh.

sue I don't think it's as bleak as that. Surely the stimulation process must affect egg quality anyway since you would never normally produce more than 1 or 2 at a time? Then those that were fertilised and did not survive a few days would never have implanted or been recognised as a pregnancy. I'm sure that is the fate of a lot of eggs on all the unsuccessful TTC cycles. So actually it was one in four embryos that never stood a chance.
I do wish genetic testing was more available after a loss. I think it would help so much to identify those women who have a problem before they've been through so many losses. If it was chromosonal it's easier to come to terms with somehow. I know my 4th loss was perfect, no idea about the prev 3 but am assuming since they all followed the same pattern and often lost after a HB developed that the fault was with me and not them I'm sure due to cost it will never happen though. duggs I'm sure that news has brought up all sorts of emotions, I hope you can start to make sense of it over the next few weeks.
scooter good luck for Friday. Rubbish about your holiday but would be awful if something happened whilst you were away. Will your insurance cover rescheduling?

Hey ladies, yes baking when I asked the endocrologist about it he said 3 normal out of 4 was pretty ok. He said 19 to start was a lot so perhaps they would try to stimulate me to produce less but perhaps they would be better quality. An assisted cycle forces eggs to ripen and ovulate in a non natural state so it isn't mimicking what would happen in real life. The key is timing of when an egg is released not too soon so immature and not too late because over mature. This has a huge significance and hormone levels will determine timing of ovulation. What I am more concerned about is whether or not out of my 6 losses all were Chromosonal? So the IVF def wasn't but could have been just failed ivf due to bad DNA sperm issue? 2 were proven trisomy 13 & 16 so what about the other 3 that weren't tested or were inconclusive? One was a blighted ovum, one a chemical ( they say are usually Chromosonal) and one was a foetus with no hb - the inconclusive one. I guess we will never know. Sue same with you - and free ... We don't know about Chromosonal issues. I will have CGH testing again with this next IVF round- if I get enough eggs. How is everyone else.?

Not good duggs
Lost the baby in the early hours of this morning. The pain was like labour, it's getting worse each time. So sad.
After hb at 8 weeks gave me 98% chance for the 4th time, I am sure the ones I am losing are ok, so it's me and my killer womb.
Starting to feel I can't do this again, my last miscarriage was only four months ago, can't keep putting my family through this.

I hope this one 'down' improves the odds for the other first trims among us, can't happen to everyone...

Hi all, quickie from me as I'm on the bus. Duggs that's shocking news again for you, I guess it's good in a way - I don't know? If it's not one thing though it's another.

Scooter, gutting about the holiday. There will be others of course but it would have been nice for you. Health comes first and you need to work out what is happening with the cysts. My mum has a large ovarian cyst and it used to affect her every month but just by causing some weird stretchy pain. Keep us updated!

Yesterday was hideous as I went in at 11 and didn't have the ERPC until 5.30, no food or drink when still feeling pregnancy sickness and Pred hunger is not fun. Plus they lost me for a few hours and in their wisdom chose to tell me to just wait my turn when I tried to see what was going on before someone else said oh we've been looking for of everywhere! They scheduled everyone with the knee operations first and I wasn't out of surgery until 6 so couldn't leave until 8pm. I will be writing a letter suggesting more consideration for people undergoing procedures that are emotional as well as physical.

Anyway, thankfully have started to feel better already. Less sick, more energy and keen to get on with having a nice healthy few months and some fun before we work out if and when and how we might try again and this time make sure we do if properly with Mr S from the off.

scooter So so sorry, would the cyst have anything to do with it, do you think? Huge hugs for you, you've been through so much.

free Shocking, they 'lost' you?? And put knee operations first? Geez, what a mess .. they really need to get their act together! Glad that you're feeling better now though.

Can't comment on the chromosomal discussion as I've never managed to get any of my MCs tested, but I'm following it with great interest.

/waves to everyone

Free can I ask what you would do with dr s properly from the off? What would be different from what you just did ? Sorry about your horrible experience. Scooter. I am so sorry again... Can't believe you lots both x

scooter, I'm so very very sorry. I'm sure doubly hard now as you have not only the grief of your loss but also nothing to buoy you up against the worry of the cyst. Although from your blood results that sounds promising. I hope that's all sorted soon.
Free, that's absolutely shocking treatment. Definitely cause for complaint. Maybe they might have treated you better had they known you were a journalist who writes about her experience of miscarriage!