"It's also not a sedative. It's a opiate which works on the brain to block
pain receptors."
It's 'sold' to mothers as an analgesic but its analgesic properties are poor for many women, which is why it's no longer being routinely offered by many hospitals.
It has a STRONG sedative effect. Anybody who has witnessed mothers in the hours after the administration of this drug would have no doubt that this is the case. Most women aren't mobile after a full dose of pethidine. Many drift in an out of sleep, become incoherent, and suffer from amnesia afterwards which distorts their memories of the efficacy of their pain relief, which is what's believed to account for the belief that pethidine and other opioids provide better pain relief than they actually do, something that's now being challenged by evidence from better constructed research.
From "Does pethidine relieve pain? A critical review of the evidence" from Practising Midwife 2005:
"Nerve and smooth muscle activity is inhibited, leading to the following possible side effects: sedation, reduction of anxiety, euphoria, respitory depression, nausea and vomiting, bradycardia and hypotension, prolonged labour, urinary retention and dysuria, gastric stasis and constipation, and hallucinations"
As for its pain relieving qualities - In the studies looked at in the review, "pain relief reported at 60 minutes post-pethidine - at best, one in five women had 'no' or 'slight' pain relief, at worst, 3 out of 4 had 'no' or 'slight' relief. "These findings seem to confirm the concerns expressed by midwives, doctors and the women themselves. Midwives are left with the uncomfortable evidence that the most common form of intramuscular analgesia they offer may not consistently achieve its purpose'
Hmmm. Haven't had heroin, but having gone out with a junkie, pethidine seems to share many of the same qualities and side effects that he described when taking heroin - sedation, disassociation, hallucinations, euphoria, constipation, nausea, disorientation.
How is pethidine essentially different from heroin then to the lay person who isn't aware of the finer differences in terms of its molecular structure, and is just judging it in terms of the recognised physiological and psychological effects of taking the drug?
"Also, you might want to look up the role of the placenta."
From the same review: "Pethidine rapidly crosses the placenta and is metabolised to the active norpethidine. Kuhnert et al suggest that the previously accepted 3 to 7 hour half life for pethidine in the mother may be an underestimate and also that norpethidine has a mean half life of more than 20 hours. They further suggest a half life of pethidine in the neonate of 11 to 17 hours and a half life of norpethidine of 29 to 85 hours. Neonatal effects of maternal pethidine use have been shown to include reduced Apgar scores and increased respitory depression, reduced early neonatal neurobehavioural scores, reduced early suckling behaviour, increased heart rate and reduced crying times."
And never mind the research - you can see it. I've seen it, and not just in my own babies.
And wasn't there research linking it with a four to fivefold increase in the odds of adult drug abuse and dependence?
On the other hand, it's very cheap and it does keep mothers nice and docile in labour, which makes them easier to look after when you're trying to stretch one midwife between two or three women.