until ds was 12 weeks old, he'd cry every evening for hours on end. he'd fall asleep from exhaustion (upright against our chests), then wake 2 minutes later, screaming in pain.
was heartbreaking. still to this day not sure whether colic or reflux (he was also projectile sick constantly, and coughed / gagged / hiccuped a lot, so think it was reflux).
anyway, ranitidine helped loads. he suddenly started sleeping in the evening and whilst he was still sicky a lot, he didn't have the pain/discomfort he had before.