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Antenatal tests

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Original poster

Grey area NIPT

3 replies

Purtyburty · 26/12/2023 20:22

Has anybody had a result from the NIPT that was a grey area? I haven't been able to contact the clinic over Christmas. They have asked for a redraw of blood and am hoping that it just meant low frontal fraction but online suggests a grey area means chromosome abnormality. Any thoughts would be appreciated x

OP posts:

Arthursmom · 26/12/2023 22:43

Did it actually say ‘grey area’? We had a redraw due to low fetal fraction…

Original poster

Purtyburty · 26/12/2023 23:14

@Arthursmom yes it did say 'grey area'.

OP posts:

Arthursmom · 27/12/2023 09:02

Oh I’ve never heard of that. A quick google brings up this https://pubmed.ncbi.nlm.nih.gov/35465819/ which says on the second run 176 out of 184 were negative on the second test if that’s at all helpful.

The performance of grey zone in common foetal aneuploidy screening by semiconductor sequencing - PubMed

A total of 15,267 pregnancies were tested by NIPT in this study. Grey zone (z score: 2.58 ∼ 4 and -4∼-2.58) was set for screening out aneuploidy 21, 18 and 13. Cases with z score located in the grey zone were retested starting from DNA extraction. The...

https://pubmed.ncbi.nlm.nih.gov/35465819/

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