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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

to feel uneasy about what this means long term rather than surprised by the weight regain itself?

682 replies

HazelMember · 28/01/2026 18:03

I’ve just read a BBC article about research into weight loss injections like Ozempic and Wegovy showing that people who stop taking them tend to regain weight quite quickly.

I’m not shocked that weight comes back. That happens after most weight loss attempts whether they involve medication or not.

These drugs are increasingly talked about as something people might take for years or even indefinitely. That raises questions for me about what happens when someone cannot afford them anymore, when supply changes, when side effects become an issue or when a person simply does not want to stay on a medication for life.

If stopping leads not just to regain but to a fairly rapid rebound, it feels less like a temporary aid and more like something that is very hard to step away from once started. That sits oddly with how casually they are sometimes discussed.

AIBU to think the real issue here is not that people regain weight after stopping, but whether we are quietly normalising a treatment that may be difficult to discontinue once begun? Or is this simply the reality of managing a chronic condition?

A woman, wearing bright red nail polish and unbuttoned blue jeans, injects herself into the skin and soft tissue of her lower abdomen with an obesity jab pen.

People coming off weight-loss injections risk fast weight gain

Overweight people shed large amounts on jabs but gain 0.8 kg a month on average once off them, study shows.

https://www.bbc.co.uk/news/articles/c050ljnrv2qo

OP posts:
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14
canisquaeso · 28/01/2026 20:22

I don’t think you’re wrong at all, it’s why I’ve been on the fence about taking them or not.

Many moons ago I took weight loss medication (although now I see it wasn’t necessary but unfortunately I have an almond mom who was happy to get it) and as soon as I couldn’t afford it anymore (private doctor, expensive prescription) I felt hunger like I never felt before in my life. I could have eaten the world.

HazelMember · 28/01/2026 20:23

TwentyFourHoursToTulsa · 28/01/2026 19:03

Well, you seem to have a problem with people being on WLI "longterm". I just wondered if that applied to all other medications as well?

So because the BBC published an article about WLI, they should now publish an article about every single medication?

OP posts:
HazelMember · 28/01/2026 20:24

Binus · 28/01/2026 19:31

It's the reality of managing a chronic condition.

WLI medication doesn't work after you stop taking it. Obese people who lose the weight through diet and exercise are likelier than not to put it back on.

Of course. but as the article said:

People who come off slimming jabs regain weight four times faster than dieters

OP posts:
soupyspoon · 28/01/2026 20:24

LeafyMcLeafFace · 28/01/2026 20:20

There is nothing in the OP’s posts to suggest that they are being at all critical or even concerned, so your emotional response is entirely related to your own projection.

Not much of an 'emotional response' I didnt use WLI to lose weight and I dont use them.

Like many others on the thread Im observing this with a raise and cynical eyebrow

There'll be another thread of the same ilk along tomorrow anyway.

velvetgeranium · 28/01/2026 20:26

People are not allowed to ask questions about or ponder the implications of WLI on MN, that is clear.

TwentyFourHoursToTulsa · 28/01/2026 20:27

LeafyMcLeafFace · 28/01/2026 20:20

There is nothing in the OP’s posts to suggest that they are being at all critical or even concerned, so your emotional response is entirely related to your own projection.

OP "feels uneasy" (see actual title of this thread). And says "If stopping leads not just to regain but to a fairly rapid rebound, it feels less like a temporary aid and more like something that is very hard to step away from once started. That sits oddly with how casually they are sometimes discussed."

That sounds like being concerned and critical to me.

RufustheFactuaIReindeer · 28/01/2026 20:28

velvetgeranium · 28/01/2026 20:26

People are not allowed to ask questions about or ponder the implications of WLI on MN, that is clear.

Of course they are allowed, they just might not like some of the responses

soupyspoon · 28/01/2026 20:28

EricTheHalfASleeve · 28/01/2026 19:58

The late lamented Terry Pratchett & the unlamented Neil Gaimen wrote a parody of this is in Good Omens - the horseman of the apocalypse Famine is a businessman who creates CHOW - ready meals designed to make you lose weight due to them having 'the nutritional content of a Sony walkman'.

He follows this with a range called MEALS: 'MEALS was CHOW with added sugar and fat. The theory was that if you ate enough MEALS you would a) get very fat, and b) die of malnutrition.'

The food industry sells us fat then the weight loss industry sells us slim.

If society really wants to tackle obesity we need a calorie tax on the food industry. Tax Just Eat and the like and subsidise fruit and veg. It's not hard to make a healthy ready meal, and if those were substantially cheaper than a high calorie version people will buy the cheap healthy option.

We also need to support our base food producers, fish, meat, poulty, dairy, fruit and veg with pulses and legumes.

The traffic light system is not fit for purpose.

The addition of sweetners to foods that either a) shouldnt have sugar at all or b) could have just lowered the sugar amount rather than replace with overly sweet artifice, should be banned

Govrenment needs to get tough with food manufacturers

We also need to stop seeing supermarkets as benign friends, they are businesses, their sole reason for existing is to sell us food that we dont want or need. They need a fat society.

EleanorReally · 28/01/2026 20:29

interesting
i was surprised this was even mentioned on the news last week.

duh,
you stop whatever diet you are on and yes the weight will come back

HazelMember · 28/01/2026 20:30

velvetgeranium · 28/01/2026 20:26

People are not allowed to ask questions about or ponder the implications of WLI on MN, that is clear.

That does seem to the case. Certain posters who are against any questioning of any possible implications of WLI can't seem to stop using the word 'fattie'.

OP posts:
HazelMember · 28/01/2026 20:30

EleanorReally · 28/01/2026 20:29

interesting
i was surprised this was even mentioned on the news last week.

duh,
you stop whatever diet you are on and yes the weight will come back

Edited

People who come off slimming jabs regain weight four times faster than dieters

Weight gain is quicker coming off the jabs, duh.

OP posts:
RufustheFactuaIReindeer · 28/01/2026 20:31

HazelMember · 28/01/2026 20:30

That does seem to the case. Certain posters who are against any questioning of any possible implications of WLI can't seem to stop using the word 'fattie'.

Still not the case

SilenceInside · 28/01/2026 20:31

@HazelMember this is a meta study looking at the trial data where participants either stopped immediately or were transferred onto a placebo. It does not represent real world use of these medications by people who are self funding and aren’t reliant on a medical trial to access the medication. I’d like to see more detailed studies on different ways to come off using WLIs to see if that makes a difference to weight regain and long term maintenance. Eg titration down, maintaining at target weight on a lower dose for an extended period, whether exercise makes a big difference, what kind and how much, etc etc.

I honestly don’t know what someone who is obese is meant to do to satisfy all the critics and concerned bystanders. Other than lose weight via willpower alone, which is the only acceptable approach it seems.

Binus · 28/01/2026 20:32

HazelMember · 28/01/2026 20:24

Of course. but as the article said:

People who come off slimming jabs regain weight four times faster than dieters

Yes. And they have much more to regain, since WLIs are more effective than dieting in getting the weight off in the first place. Notice that it doesn't say the WLI takers ended up heavier.

The reality is that we only have one proven way of making an obese person non-obese for the longer term.

RufustheFactuaIReindeer · 28/01/2026 20:32

Yes that would be very interesting silence

soupyspoon · 28/01/2026 20:32

ForeverScout · 28/01/2026 19:49

Why would you ask someone you don't know about psychoses? I have no clue about those. I'm not sure what you want from me unless some kind of "gotcha" moment, which says more about you than me.

For my part, I'm not demonizing WLIs but I think all long term meds have their contraindications, side effects, and yes their very real uses. That doesn't mean every Tom, Dick and Harry should take them, does it? Or that they are somehow above review or people thinking through starting something as to whether they actually need it?

And yes, it is a craze, at least in my area. Without medical oversight. What could possibly go wrong.

Because it shows you dont know very much about life long conditions and the likely need for life long treatment. And you're trying to apply that to obesity

tobee · 28/01/2026 20:32

You're very aggressive and also defensive op. Very goady in style.

Your style invites suspicion of your motivations.

HazelMember · 28/01/2026 20:33

soupyspoon · 28/01/2026 20:28

We also need to support our base food producers, fish, meat, poulty, dairy, fruit and veg with pulses and legumes.

The traffic light system is not fit for purpose.

The addition of sweetners to foods that either a) shouldnt have sugar at all or b) could have just lowered the sugar amount rather than replace with overly sweet artifice, should be banned

Govrenment needs to get tough with food manufacturers

We also need to stop seeing supermarkets as benign friends, they are businesses, their sole reason for existing is to sell us food that we dont want or need. They need a fat society.

I think also the increasing numbers of takeaways appearing everywhere is an issue.

https://arc-nenc.nihr.ac.uk/news/putting-the-brakes-on-fast-food/

Research shows that restricting new fast-food outlets can reduce levels of childhood obesity

OP posts:
soupyspoon · 28/01/2026 20:34

tobee · 28/01/2026 20:32

You're very aggressive and also defensive op. Very goady in style.

Your style invites suspicion of your motivations.

Exactly, as I said its the po facedness, its not genuine curiosity or chit chat, going to and fro in discussion.

Its snidey, needling, air of superiority. Not genuine.

These threads are all the same with the same tone.

HazelMember · 28/01/2026 20:35

SilenceInside · 28/01/2026 20:31

@HazelMember this is a meta study looking at the trial data where participants either stopped immediately or were transferred onto a placebo. It does not represent real world use of these medications by people who are self funding and aren’t reliant on a medical trial to access the medication. I’d like to see more detailed studies on different ways to come off using WLIs to see if that makes a difference to weight regain and long term maintenance. Eg titration down, maintaining at target weight on a lower dose for an extended period, whether exercise makes a big difference, what kind and how much, etc etc.

I honestly don’t know what someone who is obese is meant to do to satisfy all the critics and concerned bystanders. Other than lose weight via willpower alone, which is the only acceptable approach it seems.

I do agree that more detailed studies are needed and hopefully they will come out over time as more research is conducted.

OP posts:
wheresmymojo · 28/01/2026 20:37

I was considering WLI but have changed my mind due to the research about rebound weight gain.

I’ll continue to do it the old fashioned way until the end of this year and if I end up needing more help I’ll opt for gastric sleeve surgery since it physically alters your stomach size and doesn’t have the same rebound effect.

I just don’t fancy the gallstones / pancreatitis potential if you have to take it for life.

Binus · 28/01/2026 20:37

HazelMember · 28/01/2026 20:35

I do agree that more detailed studies are needed and hopefully they will come out over time as more research is conducted.

I think they will, it's obviously a very live issue. The reviewers in the BMJ piece were very clear about the limitations of their findings and the need for more research, unfortunately there wasn't so much emphasis on that in the coverage.

Pikachu150 · 28/01/2026 20:38

So what if it is a life long medication? If it reduces diseases related to obesity it will be worth it for the person taking the medication as well as the NHS.

Pyjamatimenow · 28/01/2026 20:39

I’ve been on it 2 years. Under no illusions that I would regain if I stopped taking it.

Whataninterestinglookingpotato · 28/01/2026 20:41

It’s always going to be risky just treating obesity with a drug alone. If people want to come off the drug they need to completely change their life style and fix their relationship with food. Without that people will just rebound once they stop suppressing their appetites.

counselling, cooking classes and gym memberships with personal training sessions should be offered along side and people may have a chance of keeping the weight off once the injections stop. But that would cost too much money so wouldn’t happen.