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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

to feel uneasy about what this means long term rather than surprised by the weight regain itself?

682 replies

HazelMember · 28/01/2026 18:03

I’ve just read a BBC article about research into weight loss injections like Ozempic and Wegovy showing that people who stop taking them tend to regain weight quite quickly.

I’m not shocked that weight comes back. That happens after most weight loss attempts whether they involve medication or not.

These drugs are increasingly talked about as something people might take for years or even indefinitely. That raises questions for me about what happens when someone cannot afford them anymore, when supply changes, when side effects become an issue or when a person simply does not want to stay on a medication for life.

If stopping leads not just to regain but to a fairly rapid rebound, it feels less like a temporary aid and more like something that is very hard to step away from once started. That sits oddly with how casually they are sometimes discussed.

AIBU to think the real issue here is not that people regain weight after stopping, but whether we are quietly normalising a treatment that may be difficult to discontinue once begun? Or is this simply the reality of managing a chronic condition?

A woman, wearing bright red nail polish and unbuttoned blue jeans, injects herself into the skin and soft tissue of her lower abdomen with an obesity jab pen.

People coming off weight-loss injections risk fast weight gain

Overweight people shed large amounts on jabs but gain 0.8 kg a month on average once off them, study shows.

https://www.bbc.co.uk/news/articles/c050ljnrv2qo

OP posts:
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14
Hospitalvisitguilt · 30/01/2026 10:11

A lot of people ‘being trapped on them for lifelong chronic conditions’

Does this refer to people who met the medial threshold and prescribed accordingly to manage chronic obesity/diabetes with all other risk factors taken into account OR

Does or refer to people who are privately prescribed them for being overweight or obese

The WLI were meant to be used as a last resort to reduce serious health risks associated with weight and on the short term may alleviate serious risks.

So like any other weight loss intervention that works - it has to be maintained and I genuinely would like to know if not is worth it compared to other less risky methods

Binus · 30/01/2026 10:22

Hospitalvisitguilt · 30/01/2026 10:11

A lot of people ‘being trapped on them for lifelong chronic conditions’

Does this refer to people who met the medial threshold and prescribed accordingly to manage chronic obesity/diabetes with all other risk factors taken into account OR

Does or refer to people who are privately prescribed them for being overweight or obese

The WLI were meant to be used as a last resort to reduce serious health risks associated with weight and on the short term may alleviate serious risks.

So like any other weight loss intervention that works - it has to be maintained and I genuinely would like to know if not is worth it compared to other less risky methods

Well, there aren't actually any other less risky methods when a person is already obese. Because the thing about traditional weight loss techniques is that on a population level, they don't work. An obese person who loses weight through dieting is probably going to put it all back on again.

So the actual comparison is the risk of continued, lifelong obesity vs the risk of ongoing WLIs that allow the person to stay a normal BMI. We do need to be really clear about that.

I'm open to arguments and evidence that the risk of obesity is lower than the risk of long term WLI usage, but that does mean acknowledging that an obese person probably only has these two choices. That there isn't a version that involves obese people as a population losing the weight through diet and keeping it off.

HazelMember · 30/01/2026 10:26

Wickedlittledancer · 30/01/2026 09:17

I think it’s great you spend time worrying about the prescription meds people take op. Very kind of you. To help ease your concern. That data is based on people in trials who loss an average of 8kg then gain it back at an average of a pound a week, subsequent trials on real life people ie non trial shows weight loss is much higher than 8kg on average and people keep it off, so you can google or there is another thread on here where it is linked.

anyways, this comment someone made made me laugh This is a HUGE issue. It is a drug that needs to be taken continuously otherwise you lose all benefits

there is no drug you take which when you stop keeps working. Every single drug stops working when you don’t take it. It’s moved into the land of comical that anyone actually thinks this is unique to this prescription med. 😂

No worries.

You can thank the BBC for their kindness and concern. They published the article 😂

OP posts:
HazelMember · 30/01/2026 10:27

StrawberryJamAndRaspberryPie · 30/01/2026 10:00

The same as what happens when any medication becomes unavailable. Just like HRT or statins or PPIs. People need to stop thinking of them as a lifestyle craze/fad and start thinking of them as medication to treat a disease (obesity among others).

Nobody gets all faux concerned when my eczema medication is having production issues.

Tell the BBC!

OP posts:
HazelMember · 30/01/2026 10:29

EveryDayisFriday · 30/01/2026 09:23

In that case, if you genuinely have concern about the meds then you shouldn't take them. All meds have risks, those that take them know this. I have concern with the black market meds from the beautician. I have concern with the risks of WL surgery and decided against it. I had concern about vaping but it helped me quit 15yrs of smoking, now I do neither.

I've written concern in my post so much that it seems a weird word :)

Is it not permitted to discuss the issues? The BBC shouldn't publish articles about WLI?

OP posts:
SwingTheMonkey · 30/01/2026 10:40

HazelMember · 30/01/2026 10:29

Is it not permitted to discuss the issues? The BBC shouldn't publish articles about WLI?

You’re not discussing anything though? In the past few pages of this thread you’ve done nothing but reply to people who’ve questioned your motives for this thread.

Wickedlittledancer · 30/01/2026 10:51

SwingTheMonkey · 30/01/2026 10:40

You’re not discussing anything though? In the past few pages of this thread you’ve done nothing but reply to people who’ve questioned your motives for this thread.

Some people are consumed by envy and resentment over these injections. Threads like this pop up most days from them. They think they are hiding behind faux concern, they aren’t.

op. I’m on the meds, my bmi is 20, I look and feel fabulous, I am staying on a low dose to maintain, but plenty will either stop and restart if they can’t maintain, or will maintain, it’s all personal.

im sure you’re the exception and aren’t just one of these consumed by envy and resentment though snd you do spend your days all worried for us. But you can stand down.

soupyspoon · 30/01/2026 10:53

StrawberryJamAndRaspberryPie · 30/01/2026 10:00

The same as what happens when any medication becomes unavailable. Just like HRT or statins or PPIs. People need to stop thinking of them as a lifestyle craze/fad and start thinking of them as medication to treat a disease (obesity among others).

Nobody gets all faux concerned when my eczema medication is having production issues.

Exactly I had weeks and weeks recently of my PPIs not being available, from any chemist in this area

No one started a thread for me then.

Binus · 30/01/2026 11:05

The truth of course is that all this is self fulfilling.

WLIs are newsworthy because people are interested, unfortunately for reasons that are not always morally blameless. The BBC reported on this review because it's clearly a topic the public want to read about, and they chose the headline they did because they know full well that regaining weight on WLIs will get more clicks than losing much more of it in the first place.

People care more about WLIs they're not taking than they do about other drugs they're not taking. So there are more stories, so people are more aware.

SwingTheMonkey · 30/01/2026 11:07

Wickedlittledancer · 30/01/2026 10:51

Some people are consumed by envy and resentment over these injections. Threads like this pop up most days from them. They think they are hiding behind faux concern, they aren’t.

op. I’m on the meds, my bmi is 20, I look and feel fabulous, I am staying on a low dose to maintain, but plenty will either stop and restart if they can’t maintain, or will maintain, it’s all personal.

im sure you’re the exception and aren’t just one of these consumed by envy and resentment though snd you do spend your days all worried for us. But you can stand down.

Me?!

Binus · 30/01/2026 11:09

SwingTheMonkey · 30/01/2026 11:07

Me?!

The poster switched who she was addressing in mid post, 2nd and 3rd are to OP I think?

Wickedlittledancer · 30/01/2026 11:09

SwingTheMonkey · 30/01/2026 11:07

Me?!

Nooooo, the op!

Wickedlittledancer · 30/01/2026 11:09

Binus · 30/01/2026 11:09

The poster switched who she was addressing in mid post, 2nd and 3rd are to OP I think?

Yes,,thanks.!

velvetgeranium · 30/01/2026 11:11

soupyspoon · 30/01/2026 09:06

If you're not on HRT why would you be on a thread about HRT?

I wouldn't. But any time a thread starts asking people who are not on HRT how they are finding menopause/postmenopause, it is over-run by people on HRT eager to stop discussion and persuade everyone they must go on HRT.

SwingTheMonkey · 30/01/2026 11:12

Wickedlittledancer · 30/01/2026 11:09

Nooooo, the op!

😅

HazelMember · 30/01/2026 11:18

Wickedlittledancer · 30/01/2026 10:51

Some people are consumed by envy and resentment over these injections. Threads like this pop up most days from them. They think they are hiding behind faux concern, they aren’t.

op. I’m on the meds, my bmi is 20, I look and feel fabulous, I am staying on a low dose to maintain, but plenty will either stop and restart if they can’t maintain, or will maintain, it’s all personal.

im sure you’re the exception and aren’t just one of these consumed by envy and resentment though snd you do spend your days all worried for us. But you can stand down.

I think people who keep saying others are resentful and envious are projecting their own inner worlds. That is a sad state to be in.

Feel free to report or hide the thread. Participation is voluntary 😂

I don't need to stand down. You are not MNHQ.

OP posts:
HazelMember · 30/01/2026 11:19

SwingTheMonkey · 30/01/2026 10:40

You’re not discussing anything though? In the past few pages of this thread you’ve done nothing but reply to people who’ve questioned your motives for this thread.

Can you see my PMs? WOW!

OP posts:
HazelMember · 30/01/2026 11:20

soupyspoon · 30/01/2026 10:53

Exactly I had weeks and weeks recently of my PPIs not being available, from any chemist in this area

No one started a thread for me then.

Start one yourself. Are you not an adult?

OP posts:
DarkForces · 30/01/2026 11:21

HazelMember · 30/01/2026 11:20

Start one yourself. Are you not an adult?

Awwww. Watch out your concern is showing

SwingTheMonkey · 30/01/2026 11:30

HazelMember · 30/01/2026 11:19

Can you see my PMs? WOW!

You clearly have nothing of interest to say in response to any post actually about WLI. You just want to argue with people…

SwingTheMonkey · 30/01/2026 11:30

DarkForces · 30/01/2026 11:21

Awwww. Watch out your concern is showing

This always happens. They start off with their ‘concern’ and gradually the mask slips as the thread progresses!

SilenceInside · 30/01/2026 11:39

@HazelMember what have PMs got to do with anything?

HazelMember · 30/01/2026 11:43

DarkForces · 30/01/2026 11:21

Awwww. Watch out your concern is showing

😂

OP posts:
HazelMember · 30/01/2026 11:44

SwingTheMonkey · 30/01/2026 11:30

You clearly have nothing of interest to say in response to any post actually about WLI. You just want to argue with people…

Like I questioned, can you see my PMs?

Feel free to report the post. Hide it.

Participation is voluntary.

OP posts:
Nancylancy · 30/01/2026 11:44

I think this is really interesting. I have just started (ordered but not injected yet) WLI after months of debating whether to or not, to help with weight loss to reduce my cholesterol. I am on the lighter side of obese with a BMI that requires a health condition to qualify, and my intention is to use the jabs to help me establish healthier eating habits and to address my comfort eating. My hope is that I'll only be on them for 3-6 months and then I will be in a good enough routine to maintain after that.

I'd be really interested to read the research and have a look at this study to understand why weight gain seems to happen more quickly than before once stopped. This is very worrying tbh and does put pharma companies in a position where they have power over people who need to continue taking them for life.

I don't think obesity is a lifelong condition at all - once you've lost the weight, you should be able to keep it off if you've gone about it the right way and established a healthy lifestyle. I haven't RTFT but I wonder if there is a link to the research as I'd love to understand this better.

One reason could be that WLI are correlated with loss of muscle mass (I have just attended a coaching session where this was explained, and weight training and protein were highlighted as being vital alongside the jabs). It could be that those exercising more, are then developing muscle more quickly once stopping? Obviously there is going to be an increase in appetite and some gain may be inevitable, but the mechanism of how weight gain is made faster needs to be established before people panic about it.

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