Is it the begining of the end for Weight loss injections?

[BeginingoftheendforWLI]

Just watched a report on BBC news, they did an item on a woman who had type 2 diabetes and was prescribed Mounjaro, doctors were impressed she managed to come off insulin within a month. She had some weightloss and now goes to the gym regularly.

Her doctor admitted that there was widespread concern in the medical field that people who were buying it privately for cosmetic reasons not for medical reasons could face some consequences in the future such as muscle growth and bone degeneration and lack of nutrition - they simply don't have this data at present.

Feel like this is going to be big news in the foreseeable future.

If you do go on them make sure you read up a lot more about it as tirzepatide is not insulin.

Thank you for proving my point.

I didn't say OP wasn't entitled to post, and you couldn't possibly have got that from my post. Having the right to an opinion doesn't mean the opinion is remotely well informed. And OPs isn't.

Which goes to my point. If you want to argue about cult like mentalities and not being allowed to make valid criticism, you need to pick someone who had something sensible to say. You weren't discerning enough. If more of you were capable of differentiating knowledgeable scepticism from shit stirring, what you wrote wouldn't be well on the way to being a trope.

God this is frustrating.

You say OP’s opinion is ill informed but her entire point is that issues are starting to come to the fore that could potentially create long term health concerns for users and this should be discussed. How is that ill informed? Why are users so blind to the idea that 10, 20 years down the line people might wish they’d never taken WLI because the loss of muscle mass means they’re now wizened 60somethings? And no, I am not saying for a second that will happen, but why aren’t we allowed to debate the possibility?

Ignoramus is Latin for “we do not know”, so very apt I think - we are simply informing you of the facts so you need not be ignorant of them.

It’s a pretty tame word to use (and not the one I would like to use).

Nice swerve, but let’s not pretend you weren’t using it as an insult.

Why would there be data on people who aren’t obese or significantly overweight with weight related health conditions taking a prescription medication for obesity? Medical studies don’t usually focus on the outcomes for people who illegally misuse medication.

The clinical trials looked at the outcomes for obese people taking these medications. There are known side effects as a result of those trials. We also already know about the issues around any kind of rapid weight loss, like muscle loss, bone density and nutrition. That’s why anyone prescribed WLI is advised to eat nutritious food and exercise.

So what exactly are the new revelations in this BBC story that are important to discuss?

It's interesting that you got this from what OP wrote. Because actually what you've written here is better than what she did. Why haven't you mentioned that the whole premise of her thread is speculation about 'the end' of WLIs, based on absolutely bugger all?

And once again, nobody is telling you that you're not allowed to debate the issue. You are literally squashing debate yourself by pretending that detailed criticism of arguments is the same thing as trying to stop them from being made. I've engaged more with what OP wrote than you have!

Edit- sorry that was meant to quote, dunno where it went

I'm 50 and have lost 30 pounds. BMI now 24 instead of 29.

I've always exercised but my joints were starting to ache from the additional weight. My HR is in the 120s when I run now instead of 140s, so I can do a lot more with less strain on my heart. I've started open water swimming which I'd never had done 30lbs heavier. I've had lessons and learned front crawl. I've started circuit training and keep up with people half my age. Everything I do from getting out of bed to weights and yoga is easier. Looking better is a mere side effect. I'm much fitter and have zero menopause symptoms in spite of my periods stopping 12 months ago, and having endometriosis and PCOS. There is certainly no inability to exercise, quite the reverse.

She said the beginning of the end - there’s a difference.

Insulin has been sold online to people AS WLI's there is no mistake. That has and probably is still happening and is extremely dangerous....

And didn't explain why the article has made her think this.

People seem to forget that. To be obese at my height (5ft 4) I have to be 2 stone over a healthy weight, that would be a 14-16 also. Just because I'm short doesnt mean it's not unhealthy to be over 30 BMI just because its not 5 or 6 stone to lose.

I am now BMI 25 but my waist measurement is still more 3 inches over a healthy size for my height, something the medical profession is taking as seriously as BMI now. People have lost sight of a healthy looking weight now for sure.

Can I ask which autoimmune disease?

@Catpuss66 Psoriasis and Psoriatic arthritis. Have read of positive effects on other autoimmune conditions as well on various forums.

None of what you’ve put in your OP is new info. I’ve seen those points discussed on here several times.

People have just weighed these against the benefits to them and decided to go with the benefits.

Muscle loss is a well known issue with weight loss which can be mitigated so i don’t see how it’s a particular concern with this drug. Not sure the trials suggest a particularly rapid or massive loss either, I certainly didn’t have this. As PP mentioned, onus is on user to exercise and lose at a safe pace.

if you lose six stone and then spend 20 years bed bound and get muscle wastage that’s on you not the injections. Everyone knows how to build muscle.

The size of your clothing doesn’t decide obesity. Obesity is dependent on your height and weight. So if you are 5ft 3” and weigh anything which puts your BMI above 30 you are obese. Doesn’t matter if you fit into size 12 or a 16.

I don't know about it being the beginning of the end, but it's unarguable that we don't yet have the long-term data on them to really be sure of longer term side effects, and the downsides these may have. We'll only know that after 10, 20, 30 years of them being in use. One good reason to only use them if you are significantly overweight and running the risk of serious health issues like type 2, diabetes, not just if you need to lose a stone or so.

It is very hard to look at size of clothing and decide whether someone is obese. I am technically overweight as my BMI is 25.5, but I am very muscular and was told by a qualified nutritionist and dietician that I should just work on my fitness and not get obsessed about the scales. I am a 12/14, as I have a broad shoulders and narrow hips with very long legs. I am also busty so even when I was younger and thinner I was always a size 12/14 as my shoulders/chest don’t fit into a size 10.

With regards WLI I think people should take it if they need it and it is prescribed to them. Lying to get it and using it is a bad idea and will only end in tears eventually.

Unless you are very short, being a stone overweight would not make you obese. So you would not be eligible for prescription only obesity medication. So, essentially you are saying that you shouldn’t take a prescription only medicaiton for a condition that you don’t have. I think that most people would agree with that!

Are there any other medications, ,
@BunfightBettythat you would advise people not to take for 10 to 30 years just in case of as yet unknown side effects?

The service I use requires you to complete a live timed and location recorded photoshoot front and side wearing very tight clothes as well as a photo of your feet on the scales, combined with info about height and other medication. It is just not possible to "bulk" up your clothes to appear fatter to get through to a prescription here. I've done two more photoshoots with the same company. I'm now healthy bmi weight and am very much smaller but they know it's definitely me each time. Very happy to use this service, nice and robust though it is quite dangerous balancing on pile of books on a chair to fit into their app's photo frame with feet and arms pointing in the required direction.

Build definitely comes into it. I am a small build so look chubby until I am about BMI 21/22. The more weights I lift then I can be a bit heavier and look slimmer. What i was saying is that someone cant say a size 14 isnt obese, it probably is if you're under 5ft2.

Pear shaped people often weigh more but dont carry fat round their organs which can make them healthier, hence why BMI isnt the only thing doctors look at now. In some countries the WLI will be prescribed to people under a certain BMI if all their weight is round their middle as its so unhealthy.

Mounjaro is designed to help with T2 Diabetes, and the weight loss is a secondary side effect, which also helps if the patient is overweight (although this isn’t always the case).
It can replace some other medications such as fast-acting insulin, which itself can cause issues such as hypoglycaemia (very dangerous) and weight gain (thus exacerbating the Diabetes) and the outlook for using Mounjaro is therefore expected to be better for T2 Diabetics.
As with all weight loss aids, trying to lose weight rapidly can lead to all sorts of the problems that are being reported, as studies have shown that many people using GLP1 are not eating enough of the nutrients that they need, in their quest to get thin quickly, and this aspect is what is concerning Doctors.
If you use weightloss injections, lose weight slowly (about 500g per week), keep doing weight-bearing exercise, eat the correct amount of protein, carbs and sugars for your current weight, and most importantly, don’t increase the dose until your weight loss on your current dose “plateau’s”, you should be OK…

@Worralorra what are these studies that you’ve mentioned in your post?

They’ve been around for more than ten years for weight loss specifically already