I used to smoke cannabis because it got rid of the pain of ms. I smoked every day, because I was in pain every day and the cessation of pain made me more human. I stopped years ago as I hated all the other effects - my brain was quite muzzy enough all by itself, I was exhausted and wanted to sleep all the time anyway, so I really didn't need to smoke a drug that just exacerbated those symptoms. Although I smoked every day, the day my ms nurse told me that the cannabis trial had shown that it could exacerbate headaches was the day I stopped. There was no addiction to fight against, no cravings, nothing.
I knew people who took all sorts of drugs. I've never heard of anyone dropping dead from taking cocaine though. Has this really happened VS?
My personal view is if all drugs were legal then you foil the drug barons and dirty dealers in one fell swoop; you are far more able to control supply, gain from taxes on sales, and - most important - have control over quality, which will cut out all the other crap that most drugs are cut with, some of which are as dangerous, or more so, than the drug you think you're taking in the first place.
You can also educate people if you open. People don't tend to die from taking an E, they tend to dehydrate because they forget to drink water when they do take it. Heroin addicts o/d because this fix is purer than usual so they're taking more than they think they are, etc.