Lots that people have already covered.
I CBA with going out at night, and always try to get a matinee performance for any theatre show or film at the cinema.
I dislike going out with big groups at the pub at night. I have turned down 2 hen parties in the past year and a half, where a group of women (15-20 or so of them) were all going to pub crawl for 3 hours, and then go to a nightclub til 3am. No thanks. I'm in my mid 50s not my mid 20s.
Going abroad. I reeeeeealllly want to go somewhere wonderful (haven't been abroad since 2018) but it all seems like too much effort. Closest airport is 40 mile away, and we would need a taxi to get to it as public transport is non existent near me. (No train station for 15 miles, and even then it would take 90 minutes to get to the airport with the changes.) And I am worried about strikes, bad weather, shit happening that gets the planes massively delayed or cancelled, and we end up being stuck for days at the airport/in another country.
Sex. CBA. Used to love it pre age 50. DH feels the same fortunately. I am really baffled when I hear of people 55, 60, 65+ going at it. I literally CBA! 😆
Children. Love my own adult children. Really can't stand young children anymore. I have zero tolerance for them. Several of the families in my street have children who are a PITA, and out of control, and the parents don't give a shit where they are as long as they're not under their feet. Can't stand the squealing and screaming that comes from them either. I have 2 adult DC (late 20s) and they have no children (and no plans to have any anytime soon,) and I am in no hurry to have grandchildren. (Though I'm sure I'll love them if/when I do have them...)
Having people around. Right up to my early to mid 40s I used to have visitors once or twice a week (family/colleagues/neighbours/friends.) And there was always friends of my DC around. (3-4 times a week.) Had a houseful of people quite often. Now I HATE having people in, and much prefer to just meet them for a coffee out, or pop to theirs. I can control how long I spend with them then. I had a bellyful of people coming at say, midday, and overstaying their welcome, and still being here at 8pm 😴 Why do people have to stay so long?! I just get stressed out now at the thought of people coming to visit. I am only OK with my adult DC coming. Fortunately my social circle and extended family is much smaller than it was when I was in my teens/20s/30s/early 40s. (Mid 50s now.) So there's not that many people to see. 😄