I think there's lots of things that aren't ideal about these weight loss drugs, and I'm sad that our food and lifestyle is so bad that pretty much most middle-aged people are overweight or obese (70% of women, 80% of men aged 55-65).
Given where we are though, in this excess of awful but hyperpalatable food designed to make you overeat on purpose, these drugs are absolutely transformative for many.
They are not perfect, they risk some side-effects though the majority don't have serious ones and they can be abused (like pretty much all drugs) and they don't necessarily deliver long-term weight change, although it's hard to tell at this point.
I do think that coming on and off the drugs will work for formerly obese people, I've been on them for a period of time and am happy to come off them, but reassured that if in the future, I struggle with weight again, I will go on them again.
So many issues people have in later age are worsened by obesity, such as diabetes and arthritis/knee and hip replacements, plus they are all not helped by being less able to exercise or even just walk actively, so for me the biggest plus has been relief on my joints and ability to do exercise again.
The genie isn't going to be put back in the bottle now, whatever hand-wringing is taking place on mumsnet.