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All these weight loss drugs... surely we are heading towards disaster?

1000 replies

shellswirl · 21/05/2024 09:44

So as we all know there are various weight loss drugs that have become very popular in recent months.

It seems like the whole of Hollywood is using it.

Even regular people are spending huge amounts of money on it from online pharmacies.

I get that these drugs might be useful for certain people with real medical conditions, but really a lot of people are using it as a quick fix to be thin.

With no consideration to side effects or future health. And without thinking about what happens when you stop it?

Surely the best way to lose weight involves no drugs. No fad diets. But exercising more, moving more, eating a balanced diet. Retraining your brain and finding food and exercise you enjoy.

I say this as an overweight person too! Surely there are other ways.

If every other person is taking these drugs won't there be a huge pool of people to monitor side effects etc?

Aibu to say the whole thing makes me feel very uneasy.

OP posts:
Thread gallery
34
0sm0nthus · 22/05/2024 00:18

we are encouraging people to keep eating this processed rubbish and then at the end of it pop a pill. Great perhaps they will be thin but their bodies will still be lacking vitamins and nutrients and overall unhealthy.
Correct me if I'm wrong @TheRiddle but many of the reports I've read say people using these lose the craving for junk food?
I have no dog in this fight, I'm a dyed in the wool health freak😶

DownWithThisKindOfThing · 22/05/2024 00:28

JosiePosey · 21/05/2024 22:53

None, because I'm losing it the natural way, through proper diet and exercise.

The real issue with you Josie Id suggest is that you do actually want to take one of these meds but are either (a) too scared or (b) can’t afford it (both of which are reasonable ways to feel btw) so it somehow makes you feel better to slate the medication and/or people who take it. You clearly know nothing about it to come out with some of the nonsense you have.

TheRiddle · 22/05/2024 00:31

User14March · 22/05/2024 00:14

@TheRiddle it’s very possible, especially as a menopausal and post menopausal woman, to avoid all UPF & eat well & watch the scales edge forever upwards & to become obese.

You may well be right. I am in my fifties now and this the first time since my early forties that I have found myself needing to shed stones of weight.

I hope I can get back to a healthy weight doing it the old fashioned way but we will see. I'm aiming for normal. I don't mind being a bit overweight like a stone. Just not morbidly obese which is where I started the year. It will be interesting to see how it compares to my younger self losing weight. I'm almost certainly in peri now but still having periods.

I definately want to keep away from UPF. I seem to have quite a few neighbours in their late fifties, sixties and seventies and they are all slim. So either they are all on the drugs in secret or for some people it can be done (post menopausal and slim).

DownWithThisKindOfThing · 22/05/2024 00:32

0sm0nthus · 22/05/2024 00:18

we are encouraging people to keep eating this processed rubbish and then at the end of it pop a pill. Great perhaps they will be thin but their bodies will still be lacking vitamins and nutrients and overall unhealthy.
Correct me if I'm wrong @TheRiddle but many of the reports I've read say people using these lose the craving for junk food?
I have no dog in this fight, I'm a dyed in the wool health freak😶

Yes this is how it has been with me. Once I no longer got a “hit” from junk food there is no reason to eat it, so it’s easier to avoid.

Changing mindset is so important though. I stopped drinking because I changed my mindset and saw alcohol for the muck it is. It’s easy to avoid alcohol though, but we all need to eat! This medicine hopefully will help me see crap food how I now see alcohol ie as self harm and not a “treat”.

kkloo · 22/05/2024 00:35

TheRiddle · 22/05/2024 00:06

OP, I do agree with nearly everything you have wrote so thank you for starting this thread.

Like you I think we are going down the wrong path with this one.

We have an obesity crisis. The reasons are complicated but a part of it is that people eat a huge amount of ultra processed food (it's not food!) and less and less actual real food. Our bodies do not like this UPF and it tells us this by weight gain and all the other health issues that happen when we fuel our bodies with 'crap' rather than nutritious real food.

In my thirties (many years ago now) my husband and I embarked on a healthy eating exercise. It started because I wanted to lose weight as going on a once in a lifetime holiday. We basically ate salad, fruit, vegetables, fish, chicken and all the good stuff. We eliminated all the bad stuff. I lost the weight I wanted to lose. However other things began to happen. I had more energy, my skin was better, my hair was shinier, my nails grew quicker. My optician was amazed when I went for my regular check up that my eyes appeared to have 'healed themselves' and I no longer needed contact lenses. In my thirties my vision had improved. It was clearly something he did not see often or at all. I can only attribute this to going from eating processed food to eating exceptionally well.

So yes I looked better and cured my obesity but much more than that happened.

I agree what you have said rather than fix the problem at source we are encouraging people to keep eating this processed rubbish and then at the end of it pop a pill. Great perhaps they will be thin but their bodies will still be lacking vitamins and nutrients and overall unhealthy.

You made a very good comparison of antidepressants.
You are depressed they give you antidepressants and so you feel better but it does not address the source of the issue. For that you need therapy which is much harder work and takes much longer. Far easier to take the pills and ignore the issue. (I speak from personal experience here, abusive childhood, lifelong depression and anxiety)

You are fat, they give you diet pills so you are thin but it does not fix the fact your body is not being fueled properly.

I get it. Life is difficult and complicated and busy. People have horrible jobs, long commutes, kids, relationship problems, dying relatives. Far easier to eat a frozen pizza that chop up some vegetables. Again I speak from personal experience (last 5 years of life looking after someone who was dying and my weight ballooned by about 5 stone due to stress, exhaustion, depression and just eating to comfort myself). I started this year to try and look after myself better. Cut out all ready meals. Start reading the packets and boxes to see what you are actually eating. More fruit, more vegetables. I haven't increased my exercise at all. I don't do anything apart from walk dog and housework and gardening etc.

I am still eating I reckon around 2200 calories a day. I'm not really counting but I am eating decent portions and not hungry.

I am changing my mindset from 'a box of icecream isn't looking after yourself or a treat'. A box of icecream is a box of sugar and chemicals that poison you and make the food manufacturers rich and you ill. A treat is a punnet of waitrose organic raspberries which taste delicious and provide my body with something it needs.

It's not always easy. At the start I craved icecream like a drug addict but as time goes on I am finding food is becoming less important to me. I think about it less. When I'm hungry I find something to eat and try and make it something decent. I've lost my taste for sweet stuff. The ben and jerry icecream I ate last week was decidely disappointing. This must be because my taste buds have changed.

I am still overweight. I still have about 3 stone to lose. One thing I know though after watching all the documentaries on UPF. It's literal shit. Not food. The food manufacturers must be laughing their way to the bank at us 'mugs' being taken in with their bullshit advertising. This thought is really helping me stay away from UPF.

I take on board that lots of the posters have said they are exercising, trying to eat better AND take the weight loss drug. However like you I think it's better to work with mother nature and do it the old fashioned way.

It's a complicated subject and I can definately see the attraction of taking a pill and getting thin that way.

Good thread.

I don't think anyone is encouraging people to keep eating processed rubbish and then pop a pill, from what I've read people on weight loss drugs seem to go on a healthy diet.

As for what you said about antidepressants.....I think it's overused for sure, but therapy is not the solution for everyone either. And you'll also find that many have tried the medication and therapy route for a long long time and got nowhere either and have now turned to something more radical...psychedelics and many are saying that they changed their lives, whether that's micro-dosing or bigger trips.

You say you're still overweight, less than 1% of formerly obese people actually get to a normal weight. You sound like you've beaten the cravings so hopefully you'll be one of that (less than) 1%, but the stats should surely tell you that the current approaches have not been working by themselves, which is why new radical approaches have now been introduced.

Perhaps there will come a time in future when UPF is in fact banned, that will be great for that generation of people, but it's not going to happen anytime soon, so what about this cohort of people who need help now? Do you think they should still be focusing on the plan that has a less than 1% chance of working?

User14March · 22/05/2024 00:36

@TheRiddle in 50s/60s your appetite doesn’t get the memo you need to cut back & tougher the shorter you are.

I think genetics almost seems to play a bigger part in late 50s, the long & lean ectomorph being at an advantage. I am shocked how some even have visible abs being sedentary bigger eaters.

TheRiddle · 22/05/2024 00:36

0sm0nthus · 22/05/2024 00:18

we are encouraging people to keep eating this processed rubbish and then at the end of it pop a pill. Great perhaps they will be thin but their bodies will still be lacking vitamins and nutrients and overall unhealthy.
Correct me if I'm wrong @TheRiddle but many of the reports I've read say people using these lose the craving for junk food?
I have no dog in this fight, I'm a dyed in the wool health freak😶

That's very interesting. Do they put weight back on/ go back to their old ways when they come off the pills though?

Babadoobiedoo · 22/05/2024 00:36

User14March · 22/05/2024 00:14

@TheRiddle it’s very possible, especially as a menopausal and post menopausal woman, to avoid all UPF & eat well & watch the scales edge forever upwards & to become obese.

Yup. I avoid UPFs, very fruit and veg focused diet, but I got older and then had a couple of illnesses/ injuries that kept me from moving much, and put on a shocking amount of weight over 2 years. Some of this was creeping portion size and a bit of eating (healthy foods) in boredom, but when I tried to shift the weight none of the strategies that had worked in my 20s and 30s worked in my 40s- I had to reduce calories drastically to see the slowest movement, and mentally/physically it just wasn’t sustainable. I was hungry all the time, and every thought revolved around what I would eat and when.

on Wegovy I am not constantly hungry, and am able to have make rational choices and not obsess all day about every bite. I’ve lost 1-2 pounds a week, so has not been a quick fix, but I would not be where I am today without the additional support of medication.

TheRiddle · 22/05/2024 00:46

User14March · 22/05/2024 00:36

@TheRiddle in 50s/60s your appetite doesn’t get the memo you need to cut back & tougher the shorter you are.

I think genetics almost seems to play a bigger part in late 50s, the long & lean ectomorph being at an advantage. I am shocked how some even have visible abs being sedentary bigger eaters.

Jeez, wish me luck then. I'm tall but I'm also an apple shape.

I was overweight in my twenties. Lost it in my thirties and kept it off for about 10 years.

Got fat again in my late forties.

Better pray I have got good genetics then. It will be interesting to see how it goes. I have heard other women saying it gets tougher after 50 though so I do believe you.

I may resort to interogating my slim neighbours if all else fails to see what their secret is.

queenparrot · 22/05/2024 00:48

Babadoobiedoo · 21/05/2024 15:42

You clearly don’t understand how pharmaceutical evidence generation works. 2 years is very long for a RCT.

That trial was for use for diabetes. These drugs have only been used off-label for weightloss until recently.

User14March · 22/05/2024 00:48

@TheRiddle lol, sex & drugs & rock & roll? ;)

kkloo · 22/05/2024 00:54

queenparrot · 22/05/2024 00:48

That trial was for use for diabetes. These drugs have only been used off-label for weightloss until recently.

They didn't just pluck the notion out of the sky though.
When the drug was originally being developed it was showing as promising for diabetes and also for weight loss, but they focused on diabetes.

https://www.nytimes.com/2023/08/17/health/weight-loss-drugs-obesity-ozempic-wegovy.html

TheRiddle · 22/05/2024 00:57

kkloo · 22/05/2024 00:35

I don't think anyone is encouraging people to keep eating processed rubbish and then pop a pill, from what I've read people on weight loss drugs seem to go on a healthy diet.

As for what you said about antidepressants.....I think it's overused for sure, but therapy is not the solution for everyone either. And you'll also find that many have tried the medication and therapy route for a long long time and got nowhere either and have now turned to something more radical...psychedelics and many are saying that they changed their lives, whether that's micro-dosing or bigger trips.

You say you're still overweight, less than 1% of formerly obese people actually get to a normal weight. You sound like you've beaten the cravings so hopefully you'll be one of that (less than) 1%, but the stats should surely tell you that the current approaches have not been working by themselves, which is why new radical approaches have now been introduced.

Perhaps there will come a time in future when UPF is in fact banned, that will be great for that generation of people, but it's not going to happen anytime soon, so what about this cohort of people who need help now? Do you think they should still be focusing on the plan that has a less than 1% chance of working?

you make some good points and I hope you are right and that the people who take the drugs do so because they are also eating well but still carrying weight and needing a final push

My fear was people would keep stuffing UPF in them/remain unhealthy and then take the pill to get slim. So they look healthy but actually aren't if that makes sense.

Others saying the pill actually changes your eating habits so I hope that is true.

Quite happy to be proven wrong.

I did notice in the Telegraph today Nestle are making special protein food for people on weight loss drugs because they think their sales of their UPF products are going to drop quite significantly due to these drugs.

Nestlé reformulates its food for Ozempic and Wegovy users (telegraph.co.uk)

After watching all these documentaries on UPF and the food industry I wouldn't trust Nestle & others as far as I can throw them.

Nestlé reformulates its food for Ozempic and Wegovy users

Food maker launches new protein-enriched range for people trying to lose weight

https://www.telegraph.co.uk/business/2024/05/21/nestle-reformulates-food-ozempic-wegovy-users/

Babadoobiedoo · 22/05/2024 01:02

queenparrot · 22/05/2024 00:48

That trial was for use for diabetes. These drugs have only been used off-label for weightloss until recently.

There is now very robust data in obesity, and regulatory bodies have approved this use- what is your issue?

queenparrot · 22/05/2024 01:10

Babadoobiedoo · 22/05/2024 01:02

There is now very robust data in obesity, and regulatory bodies have approved this use- what is your issue?

I might ask, what's yours? You seem to pounce very aggressively on any comment that points out an off-side or shows caution around these drugs.

0sm0nthus · 22/05/2024 01:22

TheRiddle · 22/05/2024 00:36

That's very interesting. Do they put weight back on/ go back to their old ways when they come off the pills though?

Good question!
I think it could be part of a strategy to change habits, and I guess you can reduce the dose slowly?

evolute · 22/05/2024 01:32

OligoN · 21/05/2024 10:24

You are not being unreasonable at all.

What I find disturbing is the amount of money being diverted/invested by companies (like my employer) to manufacture weight loss drugs which is being taken away from research into diseases which are not primarily caused by society.
At some level I actually find it obscene.

Yes, obscene…

and yet, we’ve had a solution to erectile dysfunction for decades now. How lucky the world is that this ‘disease not caused by society’ was addressed?!!

Drug companies will always invest where the money is. Universities and RIs do the real mechanistic basic biology research to underpin the direction of application. For this reason, niche areas change in waves depending on success.

I work in research. This doesn’t work the way you have fantasized.

There are drugs everywhere for every kind of ailment (perceived or realised) and yet the media have helped demonised this, why?
Like addition, high cholesterol, flaccid dicks, high blood pressure, muscle injury, ETC - all have a medicated solution of some sort but the individual still has to put in the work to improve their situation !!! Do we vilify those people in the same way or say they are not deserving of this amazing discovery change their lives for the better?

Honestly!!!

kkloo · 22/05/2024 01:36

TheRiddle · 22/05/2024 00:57

you make some good points and I hope you are right and that the people who take the drugs do so because they are also eating well but still carrying weight and needing a final push

My fear was people would keep stuffing UPF in them/remain unhealthy and then take the pill to get slim. So they look healthy but actually aren't if that makes sense.

Others saying the pill actually changes your eating habits so I hope that is true.

Quite happy to be proven wrong.

I did notice in the Telegraph today Nestle are making special protein food for people on weight loss drugs because they think their sales of their UPF products are going to drop quite significantly due to these drugs.

Nestlé reformulates its food for Ozempic and Wegovy users (telegraph.co.uk)

After watching all these documentaries on UPF and the food industry I wouldn't trust Nestle & others as far as I can throw them.

Yes it makes perfect sense but no that doesn't seem to be the case, people are reporting eating healthy diets and being turned off junk food.

There is already 'normal weight obesity'/metabolically obese, normal weight/skinny fat people out there who are slim but have dangerous amounts of body fat compared to muscle and are at risk of much of the same things that obesity puts you at risk of, some are even more at risk than some obese people depending on where they store their fat!

So if there was some magic weight loss drug that allowed people to still eat loads of junk food and therefore didn't really help to limit many of the health issues then I would be a lot more wary of the drugs because then it would just be hiding the problem for a little bit longer, but they'd still all be there like a ticking timebomb.

User14March · 22/05/2024 01:38

Did Adele use these drugs to help on her weight loss journey? I doubt she’ll ever gain weight back.

queenparrot · 22/05/2024 03:56

Who knows what Adele did - gastric sleeve, bypass? But according to this fellow, Dr Christopher McGowan, Gastroenterologist + obesity medicine specialist:

McGowan explained that once the medication is no longer present in the body “normal levels of GLP-1 and appetite can come back quite rapidly, and so that can lead to weight regain, which is essentially the norm”.

According to McGowan, clinical studies have shown that patients who stop the medication typically regain two-thirds of their lost weight within a year.

Weight regain varies among patients, with some regaining faster than others. Some even regain more than they have lost while being on Ozempic.

oakleaffy · 22/05/2024 04:11

So these drugs have to be taken for life?

costahotchocolatesaremyweakness · 22/05/2024 04:27

oakleaffy · 22/05/2024 04:11

So these drugs have to be taken for life?

That is how they are intentioned. Similar to others on this thread mentioned, I’m on the lowest dose and do not want to go up. Im slowly losing weight (I’m overweight but no longer obese), and once at a sustainable healthy weight, I plan to come off it and try to maintain the weight I’ve lost through diet and exercise, both of which were in place before, but I was seeing little results with/had epically plateau’d. If it goes back on I can reassess. I know a few people who stopped the medication and did not gain back their weight, but the lifestyle changes did stay in place.

coupdetonnerre · 22/05/2024 05:34

SabreIsMyFave · 21/05/2024 10:12

I don't think anyone believes that you will take one dose, and be 10 stone lighter the following week FFS. 🙄

But it's a sad situation we are in, when people have to take DRUGS to lose weight!

AND Control type 2 diabetes! People aren't just FAT! They also have type 2 diabetes, insulin resistance which is far more dangerous that just saying "I need to lose weight". Diabetes is an illness that needs medications whether you are fat or skinny! The great this about these drugs is that people lose weight which in some cases means no more type 2 diabetes, risk of heart disease, peripheral neuropathy, amputations, stroke, retinopathy etc.
This is all positive at a time when the NHS is on its knees!

heartbroken40 · 22/05/2024 06:08

I'm slim (hard work, never been overweight) but I see friends taking semaglutide losing lots of weight. One lost 5 stones since August! Only thing her face looks older but she doesn't mind. These drugs have lots of benefits but if you don't want to take them so be it. Each to their own. Being fat has health and also social consequences so these drugs provide a level playing field.

Riversideandrelax · 22/05/2024 06:28

tennistimetomorrow · 21/05/2024 22:58

Good God is that how it works ??

If only all us fat people knew that this entire time. JosiePosey you may just have saved millions of people from obesity.

You're missing one of the (blindingly obvious) benefits of these medications so let me help you out. These types of medications make it easier to maintain a calorie deficit thereby causing fairly rapid weight loss.

You feel fuller for longer due to delayed gastric emptying and cravings are lessened, food noise too, so it's much easier to choose healthy options.

Do you really think the reason you are overweight is simply because you "choose not to follow a healthy diet" ? There will be many complex biological and social reasons that you cannot/ do not follow a healthy diet. Insulin resistance, gut biomes, genetics all play a part. Mounjaro helps alleviate these so that you can choose healthy food.

I keep seeing this mentioned. What is food noise, please?

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