I've done a very similar commute. 3dpw for 4 years. 5.45 am train in. Out of the office on the dot of 4pm
Train was 1h10, tube 12 min, I live a 4/5 min walk from the station. Door to door it was 1h40 in, 1h 50 home (the extra 10 mins were to get a seat and make sure I didn't miss the train).
Living very close to the station (so no "last leg" to speak of) was massive plus. A drive, even a short one, would have stressed me out I think!
I have to love my job and love where I live. And be relentlessly positive (with myself) about the advantages that the long commute bought me/us (salary! Space! Job satisfaction! DH & DCs loving out home!) as it does grate sometimes. ESPECIALLY in the winter. November and Feb are HARD
The big price was any sort of social life, I couldn't make spontaneous plans or risk a late night on a weekday.
10-12 hours commuting a week is a lot of either "me time" or "family time" that gets eaten up. He needs to be ready for saying no to some things.
Its definitely doable. Especially if he's up for it. But do be realistic about the door to door.
Also - I'd rather walk Victoria to Green Park than get the tube! It's quicker and a lovely walk! If you can make Victoria your terminal, it's a huge difference.