Pfizers will look down on Oxfords

[Mentum]

AIBU to think that vaccine snobbery will be a thing?

Pfizer : Waitrose
Moderna : Sainsburys
Oxford : Morrisons

I hope not but OP sadly it may occur.

OP you forgot Tescos!

Yep German vaccine for me too. My Miele washing machine lasted for 14 years.

No thanks I’ve had the Pfizer

Imagining when that line could be used

@HelloitsmeMargaret

Oxford/AstraZeneca is being distributed to developing countries on a non profit basis. That makes them the Co-Op.

Or Waitrose - as that's a workers co-operative too.

@MarshaBradyo

No thanks I’ve had the Pfizer

Imagining when that line could be used

Depends whether the vaccine becomes its most famous product, ahead of the little blue pill

I doubt there will be signs telling you which vaccine you are getting. Much of the mass vaccination programme will be delivered on a drive through or walk through basis so you won't be around in the room long enough to be asking questions.

As an aside, Pfizer keep me alive. I’m on a new second generation TKI (for leukaemia) and they are the sole manufacturer

(I’ll have whichever vaccine is safest and most likely to stimulate an immune response in my wonky system)

I don't fancy a mrna vaccine myself. Brand new technology

Brand new technology

So is genetically altering a chimp adenovirus to carry a corona spike

Wait, why is the Oxford apparently fucked?

@Summerstorms

Wait, why is the Oxford apparently fucked?

It's not, it may need to undergo more trials re the dosing.

www.thetimes.co.uk/article/astrazeneca-defends-oxford-coronavirus-vaccine-as-disquiet-mounts-over-the-results-mf6t57rnr?shareToken=58b56141f215a08d04fc01e481998619

It is not fucked @summerstorms it just needs more/broader trials of the low/high dose to see if the 90% efficacy works across all cohorts. The temperature issue is massively important. Does anyone believe that there is worldwide infrastructure to store vaccines at the Pfizer temperatures or do we only care about rich countries.

@RoseandRose good point! Pfizer is M&S 😁

@Hopoindown31

I doubt there will be signs telling you which vaccine you are getting. Much of the mass vaccination programme will be delivered on a drive through or walk through basis so you won't be around in the room long enough to be asking questions.

That was how the flu jab was done, and we were all given the leaflet/information sheet that cane with the dose.

I think Oxford will look down on Pfizer and Modena's appalling disregard for the rules of grammar!

Pfizer vaccine: effective, protective and safe
Modena vaccine: effective, protective and safe
Oxford vaccine: effective, protective, and safe

(Got to love an Oxford Comma joke in a time of crisis! )

@Summerstorms

Wait, why is the Oxford apparently fucked?

They're doing a further trial to prove or disprove the 90% with a half dose then a full dose to follow, particularly it needs to be evidenced in the over 55's.

But the 62% is solid, is still applying for approval and is a good starting point. No doubt we'll end up with better as time moves on but right now it can still be helpful.

Nothing is fucked, if anything we should find it reassuring that they're thorough with all their processes and not just rushing ahead.

Blimey. Well currently the oxford vaccine trial looks so poorly run it won't gain clearance anywhere but in the uk and even that's dubious.

They used different control arms in the oxford study. It's just unbelievable. The control in the uk received a saline injection. In Brazil they received a vaccine against a bacteria known to cause menengitis. The "subgroup" is a cock up and means the only the patient in the intent to treat protocol can be submitted for approval. They may not get statistical significance when you take out the 2700 or so cock ups. This was SO poorly done.

You absolutely have a right to know which vaccine you are getting. It's called informed consent!

@bubbletrouble1

They used different control arms in the oxford study. It's just unbelievable. The control in the uk received a saline injection. In Brazil they received a vaccine against a bacteria known to cause menengitis. The "subgroup" is a cock up and means the only the patient in the intent to treat protocol can be submitted for approval. They may not get statistical significance when you take out the 2700 or so cock ups. This was SO poorly done.

I’d like to know why a different injection in control group.

But I did see they got approval to continue with smaller dose from regulators.

To test the smaller dosage and run a trial with a smaller dose. Not to use it on the general population.

So any approvals are a long way away yet

@Trut

To test the smaller dosage and run a trial with a smaller dose. Not to use it on the general population.

So any approvals are a long way away yet

For that dose. Or did you mean in general?

They have already said they will continue trialling with smaller dose which makes sense.

For that dosage. I doubt anyone will want two full doses if it is far less effective. So I assume they need to run a full trial with the new dosing regimen

Yes, makes sense for them to trail, I don’t know why the results were publicised the way they were. Probably to seem equivalent to the other two vaccines. Backfired a bit, as they are seen as having made claims which are not really underpinned by data

They should have said we are 62% effective and trying different doses to see if we can better that

Makes sense to retrial - the disparity between efficacy was seemingly found by accident?
So it’s either 62% at two full doses (confident) or
90% at half a dose then a full dose (may just be statistical noise)

If the second one turns out to be true, then three full doses can treat two people. That’s worth exploring. But in the meantime, surely 2 full doses at a confident enough rate of 62% is worth rolling out until such time as they receive the results back from the further trials?

I understand that the findings have not been peer-reviewed yet though?