I've lived all over - London, SE, NE, NW, SW. There are so many things to love about SW. I particularly loved easy travel to Cornwall for weekends, beautiful coastal walks on the doorstep, some lovely towns and a quieter pace of life.
However, there were some challenges imho. Wages are not in keeping with the increasing cost of housing, particularly in Devon & Cornwall. Jobs you'd earn £15- £20k more in the SE for. That used to be uncommon, but it really isn't now. It was one thing when you could buy a detached family home there for £200,000 but those days are long gone.
The other thing I found hard, was there was there were many people who had only experienced SW, and sometimes I felt they lived in a very insular bubble where different ideas were seen of as 'weird', 'unusual' and I often found they just hadn't been exposed to the diversity of thought, opinion, background etc in the same way as other parts of the UK. In fairness you can get insularity everywhere, but it really stood out to me, especially working in health care. I know colleagues in health care found the same, it was a bit like going back 10-15 years at times with regards to policies, practices and openness to new ideas. Kind of like a 'this is how we've always done it' approach when evidence and practice has moved on.
Not sure the latter would make me not live there, but something to be aware of.
Good that you love where you live @Iftheclouds that's really all that matters.