Elizabeth Bennet is smug, judgemental (the second of which obvs is the point) and patronising, especially to her sister Mary.
Hermione and Jo March I'm with PPs. I can't bring myself to dislike Rose, but can see the point. As a senator's daughter it's only her extreme privilege that allows her to get away with behaviour that would see anyone else expelled. And setting up the SSUC does make her a bit of a hypocrite ...
On the topic of school stories: Alicia Johns of Malory Towers is a Class 1 Bitch. Darrell Rivers shares that trait but to a lesser extent: she's boring but a violent bully who always picks on kids who are weaker than herself.
Nelly Dean of Wuthering Heights is a truly malignant witch wearing the guise of a cloak of benevolence.
Maud Bailey of Possession is the kind of academic who thinks she has a monopoly on her chosen research area. Anyone who's ever met these types can attest to what arrogant, smug pains in the arse they truly are.
Adam Dalgleish. I think his target readers are supposed to fancy him - P D James certainly seems to - but despite his love of fine wines and intellectual pursuits he's anti-social, judgemental, has a horror of the sick and the disabled and is sometimes downright cruel.
Miriam Henderson (AKA Dorothy Richardson) delights and irritates me in equal measure.