I think it's dangerous to assume your instincts are always right. Its learning to interpret thise instincts in a reasonable way. I spent my formative career in some genuinely dangerous situations but specifically also with people who taught me change in person is a real thing.
I learnt to trust my situational instincts. I was daily in environments where it was common to be assaulted in a variety of different and unpleasant ways. I learnt , fast , to trust my instincts on changes in behaviour, almost imperceptible alterations in look in the eye. It many times allowed me to move fast enough , just before a punch or kick landed, or I got pushed up against a wall.
People though , I am careful to sense check it, Do they remind me of someone ? Have they used words or behaviour that link to something else ?
I've found I react strongly to people who have similar appearance and mannerisms to dsis. I'm careful not to judge until they have done something tangible.
I've also spent a lot of time with people that have done things that would make mumsnet cry , but would be unlikely to flag.
Saying that , on occasion , and I've had it with truly horrific evil people , that the instinct is so visceral and so strong I have to back off. Those have always been accurate but very very rare. If it's happening commonly I would argue that's judgemental, true evil, true unpleasantness is not that common.
My ds and many within my family are ASD , and we see peoples reaction to them. I suspect it doesn't happen with us their behaviour doesn't flag as atypical to us. This however is a blessing and a curse because we are not always the right people to help with social assimilation as we don't always see things as an issue that will set other peoples instincts off.