Any first time mums with own eggs age 46 after recurrent m/c history?

[Getintogear963]

Hi ladies
Just wondering if there’s any of you who’ve become first time mum’s around age 45-46 with own eggs and trying naturally?
I’m 45 not yet a mum. My history is (from age 39 to 43) : a Down’s syndrome aborted pregnancy (baby was very ill) followed by 4 miscarriages. I also had one round IVF in June 2017 but didn’t get pregnant.
My last m/c was Dec 2017 and I’ve done nothing since! But hubby and I thinking to get back on horse again and give it one more year to just go for it and try. We want our own biological baby.
Any success stories you can share? I know it would be a miracle but these can happen!
I’m 45, periods still like clock work and to date after seeing several top specialists and investigating the NK cell route through to so many others.... (I’m an expert!) the reality is that it’s just been “bad luck” for me. There’s always a chance of throwing a six in the dice.... I’d love to hear from you successful older first time mums! Thank you 😊

BillieEilish And PicsInRed. Wow 😮 thanks for sharing xx

Hello op, I don't know any first time mums but I know three women and FF the top.if my head who had children naturally at 45, and my sister's running club acquaintance had a baby naturally at 47 recently.

*off the top of my head

I read (could be nonsense) that your mum's age at menopause minus ten years is when your egg quality/fertility drops.

With your history, if I were you I'd seriously consider donor eggs. I know there's the genetic issue but would it not be preferable to being childless if it's really important to you to have a child/ren?

I know someone who fell pregnant, unplanned at 47, healthy pregnancy, the child a healthy 7 year old.

Me however, I threw the towel in at 43 after too many losses.

Incidentally are you taking ubiquinol/Q10?

I agree with Peper and tbh OP I’m
Not sure it’s helpful having people tell you about people they know who got pregnant late. It doesn’t have any bearing on your own situation- some people are just fertile very late- but not many people. They are the exception.

I also wouldn’t bother with hormone checks unless unless you’re going to Do ivf. All they tell you is the numbers you have left, and it’s quality you need to be interested in. There isn’t a test for that, apart from testing embryos you retrieve during ivf. I would talk to a few clinics and see what they say. Good luck. I know that this sucks- I myself had to do ivf for my first DS at 35 as I had low ovarian reserve.

Gilbert- yes I read that too- the idea that you become Infertile 10 years before menopause. Makes sense I suppose.

My Nan was 49 when she had her only child, my Mum. She’d been married for years and obviously got a surge of fertility prior to menopause. I still have photos of my Nan holding her tiny newborn, the look of utter amazement is beautiful.
Women in my family are late to go through menopause.
One of my closest friends has had her fifth last year aged 47, a surprise.
Things do happen.

New research is implicating sperm age in a number of foetal abnormalities.

In other words, a 40 year old woman conceives with a 55 year old man, with abnormalities, this was previously attributed to maternal age, now thought to be contributed to by reduced sperm quality.

I’m in very much the same situation as you and have basically decided to do the same thing. A few more throws of the dice. I’ve been to the miscarriage clinic at st Mary’s and the doctor I saw there said that she had had the same experiences as me (miscarriages, failed ivf etc) and had given up...and then fell pregnant naturally at 45. She did say somewhat ruefully ‘I was going to retire at 55 - I’m not now!’. Anyway. You just never know.

Peperthecat statistics (and my consultant agreed) show that actually falling pregnant naturally is more likely.

But you could be repeatedly falling pregnant with aneuploid embryos that are destined to miscarry. If she does an egg retrieval and gets a few good normal embryos then she can try transferring them one by one in the hope that one sticks. If she doesn't get any normal embryos then that will at least tell her that her egg quality is the likely culprit and that she needs to readjust her expectations or consider donor eggs. Failed IVF doesn't stop you from continuing to try naturally if it doesn't work, but continuing to try naturally might stop you from trying IVF later if your window of opportunity is closing.

I read (could be nonsense) that your mum's age at menopause minus ten years is when your egg quality/fertility drops.

My experience would bear this out. My mum had her menopause at 44 (after conceiving easily in her mid and late 30s). I was starting IVF at 34 having been ttc for 4 years.

OP I hope you get your baby.

Me too Serendippidy- I struggled at 34/35 and had low ovarian reserve. My mum went through menopause at 47. I doubt I could have conceived at 37 onwards.

I'm so sorry for your losses, OP.

If you're looking for stories then of course they exist - my grandmother had my dad at 45, much to the disgust of his 18 year old sister! But she was a surprise baby too (a war one) - and that's the thing, nearly all of these stories are about women who found conception very easy (perhaps too easy) when they were younger and so who were probably always unusually fertile. Extrapolating from them to someone who has actively tried and not had a successful pregnancy when younger is not really comparing like with like and - I'm really sorry - it's likely to be wishful thinking.

Worriedteacher1 Haha, yes retirement may just be a tad later if our miracles do happen! 😊. May I ask how old you are? And your TTC journey until now?

I’m 42 - 4 years trying. 3 miscarriages and one failed IVF despite a PGS A grade embryo (hence not bothering with IVF again - it was good as could be and still failed).

Worriedteacher1 Thanks for sharing and I’m so truly sorry for the sad and tough journey you have also endured 💐
Do you conceive easily?
All of my pregnancies have fallen really quickly (first month or two of trying).
It’ll be interesting now 2.5 years later since losing my last whether I can still conceive as quickly.

Let’s keep each other posted?
Good luck and stay strong xx

Worriedteacher1 At least the PGS has shown you there’s still some good eggs there 🙏🏻 (although I’ve not researched into just how reliable PGS is).

Interesting article from HFEA regarding PGS:

www.hfea.gov.uk/treatments/explore-all-treatments/treatment-add-ons/pre-implantation-genetic-screening-pgs/

Success at 41 with own eggs after recurrent miscarriage. Beautiful DC now playing beside me as I type. We did pre-implantation genetic diagnosis to screen out non-viable embryos. We still have four perfect embryos left.
I followed the Coventry protocol for recurrent miscarriage devised by Prof Brosens & Prof Quenby: Prednisolone steroids from first heartbeat (week 7) to week 12, progesterone suppositories to week 12, Clexane injections to week 24 to encourage placental development. No bother, easy pregnancy.
Go for it!

I also took CoQ10, folate (natural folic acid) and pretty much followed all the advice in that great book It Starts With The Egg.

I know about 3 women in real life who conceived naturally after 46 - no assisted conceptions. Good luck OP!

@StirlingWork, was that their first baby in each case? And did they have a history of infertility or recurrent m/c?