I would never do it as I know the upset and carnage it would cause. (Married with 2 adult children both left home.)
But OMG I HAVE fantasised about it. I worked full time for the first 12-13 years of my adult life before having kids, then for 20 more or so years I was working (3 to 4 days a week) whilst raising the kids, and also looking after elderly parents.
Really trying to juggle so much! I know many women can relate. I used to fantasise occasionally, about running away too, and even wished I could be hospitalised for 3 months or so, just so I could have no responsibilities, and no work, and DH could look after the kids for a change. (He was always so busy in his big important job when they were little/young, so most of the childcare fell to me.)
And now both sets of parents have passed, me and DH are in our mid 50s, and the kids have left and are independent. However, I now feel like a nursemaid and personal assistant of DH. He is 57, and has one ailment after another, he is always 'ill,' he is going to the doctors at least once a month, also various clinics and specialists, for one new ailment after another, and I seem to be spending more time with him at hospital and clinic appointments than ever before. He never goes a single month without a visit/appointment to a medical specialist. I don't really HAVE to go with him every time, but I would never hear the last of it if I didn't go; he's like a baby... 'but I don't wanna go on my OWN! I NEEEEED you with me, you're my WIIIIIFE!' 
So yeah I find myself quite regularly fantasising about fucking off and leaving him to it, as I don't think I can stand other 25-30 years of his 'ailments' and his huffing and puffing and moaning... AND going to all these fucking appointments with him. I rarely go to the docs or any specialists, and when I DO, I go alone, but he can't go alone apparently!
I seriously feel like his fucking personal nurse. 