One of my friend's daughters goes on similar type breaks.
The cons are usually that the hotels are often slightly ropey (but to date all have been just about acceptable) and a fair way out of town so you can end up spending more than expected on transport, and that the flight times are awkward so actually you don't get to spend that much time in the location and it can be quite knackering for a short break.
However, she's a budget restricted but travel orientated young lady who keeps her expectations low and isn't afraid of roughing it a bit, and has really enjoyed most of the experiences she's had. It wouldn't be for me - I like to stay fairly centrally and have enough time to relax rather than be on the go all the time - but I think they serve a purpose.