Yes. I have been permanently NC with my mother since age 19-ish, after being off-and-on NC since age 14. She was an emotionally abusive, neglectful alcoholic who blamed me for all sorts of things. 'I wish you were never born' 'Your disability is God punishing me' 'You aren't a real person'
I'm aware that she has had a difficult life herself and has psychological problems but I have to do what's best for me, and since for a long time I had panic attacks upon seeing her, that's NC. She used to wear a particular perfume and I have an instinctive stress reaction if I smell it on someone else.
I have much younger siblings and due to family arrangements, until fairly recently I saw her once a year, on Christmas Day. Always a source of stress for me. Siblings are all now adult and that doesn't happen any longer. They have regular contact with her, and I think part of it is because I looked after/protected them from her when they were small children, before social services got involved, so they don't have the same memories that I do.
She has been sober for quite some time now but for me the damage has been done, and not all of the awful things she used to say to me were said while drunk. She also accepted zero responsibility for her actions in my childhood/adolescence. 'I was drunk, it doesn't count' or 'it was a long time ago' even when that was just a few years. She also credits herself with stopping me from self-harming because she drunkenly cut herself in front of me. She didn't. She just terrified me.
If I marry, have children, or anything like that I don't intend to involve her. She wasn't invited to my (recent, mature student) university graduation and I haven't told her about my further studies or that I'm moving to Cambridge soon because I have a scholarship to study there. It's possible that other relatives have told her, but there's no direct contact.
Was it worth it? I think so. I started off being incredibly angry with her, now I feel quite sorry for her and empathise with the difficulties she's had, but ultimately, it's better for me not to be in contact with her. I don't know what I'd do if she were genuinely ill. She claims a lot of false illnesses and when I was a teenager she said she had cancer in order to get me to speak to her again. She didn't. Sometimes I feel guilty, usually when well-meaning friends or colleagues say 'but you only have one mother.' I'm also sad that it effectively means cutting off most of that side of the family, as we don't live close together and I have to avoid going to the usual weddings/birthdays/baptisms.
Honestly, I could only see myself possibly resolving it if I heard from a neutral third party that she were actually dying. That's about it. I know it sounds callous, but it's the truth.