Ok, what question did you want answering with your OP:
AIBU to worry about DS?
AIBU to expect him to let me know when he's coming home?
AIBU to be feeling differently about this than DH?
AIBU to think that men and women are generally different about worrying about adult children?
These are all quite different questions.
I think none of us can help but be mother's and therefore worry about our children no matter what their ages, I think that when living with somebody it is only considerate to let them know when one is planning on being back, and, as I said, I think everybody feels whatever they feel - nothing U about it.
If the last question is what you are asking then my answer would be: IME many men are conditioned differently from women to not feel responsible to others' wellbeing, so may well react differently to some women. However, I do not think that that observed difference has anything to do with genitals or X/Y chromosomes.
I think there are more issues with anxiety that can and should be addressed if they make life miserable. And yes, I think, as a gross generalisation, some women are more prone to taking the caring role too far. Not genetic, bot socialisation. There are no pink lady brains, and blue boy brains.