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Alternatives to Sertraline- insatiable appetite

4 replies

FlowerPowre · 25/02/2026 16:15

I've been on 25mg sertraline for about 5 months now and in that time have gained 5/6lbs. I'm 5'9 and approx 70kgs now so I know I'm not overweight but it is affecting my mood and self-esteem, although the meds have massively lifted the low mood/mood swings I was having before I went on them, even though I'm aware its a very low dose.

I just cannot lose the weight because I can't stop eating. I can't even stick to 3 meals a day. I'm constantly thinking about food where I never did before and I just don't seem to get full, or if I do it doesn't last very long! Definitely down to the meds as I wasn't like this before.

I'm going to ring the GP tomorrow and ask to try a different medication- does anyone have any experience of increased appetite on sertraline and successfully moving to a different medication?

OP posts:
Crumpypumpy · 25/02/2026 18:28

Yes both. Let me know if you find a solution as I was just told to come off them which wasn’t the resolution I wanted.

FlowerPowre · 25/02/2026 20:35

That’s not good! I will see what the GP says but I am worried they’ll take one look at me and tell me I’m not overweight so to just deal with it!

OP posts:
Lolaslashes · 25/02/2026 20:38

Same. I missed a few days and was miserable but also noticed how starving k was when back on it

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bumptybum · 25/02/2026 20:38

There is no one that is better than another. It depends on your biology. It’s pharmacogenetics.
sertraline is one of the SSRI least likely to cause weight gain so it may be that for you it’s just not great in that area. It’s trial and error a bit. Have you tried massively swapping up your meals to protein heavy? This often curbs the appetite

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