Just seen a discussion in a tech forum asking "What use is the US ?". Basically the suggestion was that the US closeness to the Islamic countries in the Middle East (against their antipathy to Israel) has been bought with the promise of holding Israel in check.
Now Trump has admitted he has no influence whatsoever on Israel, these states are very likely going to experience internal pressure from the more militant members who are saying "what's the point of dealing with the US now ?"
Basically, that's 80 years of hard work disappeared.
(Also doesn't bode well for the UK. If the US has no say over Israel, the UK less so ....)