Spurts of ageing at 44 and 60

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According to a new study, there are two, not one, time periods in our lives when we show sudden signs of ageing. There is a burst of ageing at 44, and then at 60, accoriding to research done at Stanford University in the US. This busts the general notion that our bodies and minds decline in a slow process, referred to as 'linear ageing'.

Has this been your experience?

www.sciencealert.com/study-finds-humans-age-faster-at-2-sharp-peaks-heres-when-to-expect-them

49 for me. It all went downhill very quickly and it has been a shock that it has. Eyes deteriorated, put on weight, TATT, hair thinning, really feel much older than at 48.

My metabolism suddenly changed at 39 1/2 - the amount of calories I need per day to stay a healthy weight abruptly dramatically reduced and I got my first grey hairs - but on the plus side, the autoimmune issue I had had since pregnancy started to get better!

Kids last in early 30s felt age me physically - but it was more 46 than 44 for me - last year had eyes tested 47 perfect but last few months think glasses would help - but yes weight energy all changed.

Didn't notice 60 in IL more 70 was a turning point - earlier with Dad than 60 55/56.

I agree. I have a visible scar on my chin which has been there since childhood but I hadn't seen until my mid forties, when my jawline started to sag and I met a whole new world of real estate. I could actually punch my younger self for thinking I was 'ugly'.

I didn't notice anything at 44, but it's such a long time ago that maybe I've forgotten... I certainly noticed that things like going upstairs and getting up off the floor got harder once I hit 70 though.

Definitely the 44 one for me. Suddenly needed reading glasses, when I'd been fine before. Neck got that turkey look. Hair went two tone grey and dark grey.

Went to the optician for an eye test and mentioned my eyesight suddenly getting worse and he said, "well you're in your mid forties, that's when it happens". Opticians have know all along!!!!

I’m 47 and have really aged in last few years so this did not surprise me at all. Starting to save up for a full facelift in a few years time.

Absolutely fine in my forties, major health issues when I hit sixty and it shows in my face (I look exhausted), body (huge weight gain in six months) and brain (scatty). But I'm still alive!

I’m 44 and this seems very accurate for me! I feel like I didn’t look particularly different to 30ish until about 6 months ago. I suddenly have quite an old lady neck, some eye wrinkles, grey hairs and a nice beard starting.

Don't get me started on the facial hair. It's like having a part time job just keeping it in check.😄 I had a baby at 40 so didn't really notice much decline apart from needing reading glasses. Hitting 60 has been the biggest turning point for me. More aches and pains, lines on face, saggy jaw line. I'm trying to keep it all at bay but then I look in the mirror.😅

I was thinking the same - surely babies and menopause are the step changes for women? Haven't read the article though as I'm supposed to be working.

I'm only a young one at 40 but the times I've noticed myself aging quickly were after a horrific bereavement in my mid 20s (came back from the funeral with my first wrinkle!) and when I had my DC in my mid 30s. In the photos with newborn DC1, I'm 34 and look soooo young despite also looking absolutely wrecked.

Going to try and forget anything about aging at 44.

For me it happened somewhere between 47 and 49, looking at photos of myself.

The mid-40s peak showed changes in molecules related to the metabolism of lipids, caffeine, and alcohol, as well as cardiovascular disease, and dysfunctions in skin and muscle. The early 60s peak was associated with carbohydrate and caffeine metabolism, cardiovascular disease, skin and muscle, immune regulation, and kidney function.
The first peak, the mid-40s, is typically when women start undergoing menopause or perimenopause, but the researchers ruled this out as a main factor: men, too, also underwent significant molecular changes at the same age.
"This suggests that while menopause or perimenopause may contribute to the changes observed in women in their mid-40s, there are likely other, more significant factors influencing these changes in both men and women," explains metabolomicist and first author Xiaotao Shen, formerly of Stanford, now at Nanyang Technological University Singapore.

Mid 40 with alcohol does track with me.

For me I would say 46 and 60 - at 60 though I also had a really bad 18 months healthwise post covid and the stress aged me more I feel

Facially I think it was early 50s for me that I started to look noticeably different to 15 years ago, but bodywise it was definitely a lot earlier, early 40s, when my middle seemed to develop a flabby extra tyre overnight!

My optician told me it was 42 on average for developing long sight (for me it was in addition to short sight). He told me this at my checkup aged 40 and when I went back aged 42, I had developed long sight too. No need for bifocals yet, but I have to take my glasses off to read small print.

Fine lines, yes, but 25 is quite young for a woman to have grey hair I think.

I'm 44 and I've definitely started looking much older in the last year or so. Not sure what it is but my face has sort of subtl changed-can't put my finger on what it is exactly. But it ain't good!

Most the thread is anecdotes about wrinkles.
The actual research was about molecules, things that can only be measured by a laboratory.

Now 61.5 and have noticed my skin is feeling and looking older. I am constantly moisturising as my arms and legs look scaly if I don't, and my face and cleavage are losing elasticity fast. Mentally and physically, I tire more easily and I find myself being more forgetful. It makes me feel that just trying to maintain how I am takes a big effort. All you younger women, you've got this to look forward to!

Yes... I've not read it properly but it'd be interesting if someone could follow up with whether there were correlated observed changes.

Personally I'm just delighted my the title Nonlinear dynamics of multi-omics profiles during human aging ... I really need to use the term 'multi-omics' before I retire.

Definitely had one at 44

It's started to sag and your jaw and cheekbones are not as defined . I notice this around 33/34 . The difference between photos of me in my late twenties and early thirties are very noticeable.

Same here . Same age and I keep forgetting names and get stuck for a word . I want to pee all the time and I'm in trouble if I don't get to a loo quickly as the sensation comes on all of a sudden . Same for a poop. I'm more windier too 😂. I do get tired and can't do what I used to do even though I think I can. I've also aged a lot of the last few years and the skin on my limbs have become loser but I'm the most happiest and content I've ever been and no longer care what people think of me and have become more selfish. My circle has become tighter and smaller and I love being invisible to the opposite sex. I live my life for me .

44 doesn’t ring true for me. I looked and felt much the same as at 40. Around 46/47 I started noticing a change in my skin tone, muscle tone, more aches and pains, perimenopause started.