Dairy is the leading cause of fatal anaphylaxis in children, in part because it is hard to avoid.
From reading around there are a number of possible factors relevant in this tragedy:
- Obviously, the mistake with the milk in the coffee shop. This has been the focus of the media but I think it is what followed (not administering adrenaline in time) that could realistically be learned from to save lives in future.
- Reading between the lines she was not carrying her own EpiPen (I could be mistaken) - this should never be the case for somebody with multiple allergies and known anaphylaxis. Thinking of possible reasons it could be that previous anaphylaxis was not severe or occurred years ago and there was a perception an EpiPen was not needed, a mistake by professionals (failure to identify anaphylaxis risk and prescribe an EpiPen + educate), sometimes just a tragic misfortune (accidentally left at home) or sometimes just a totally unforseeable first episode of anaphylaxis (though to be honest, any IgA symptoms and complete avoidance of dairy = epipen in my opinion)
- It seems that the EpiPen that was given was significantly delayed for various reasons (possibly including reluctance/refusal) and then a single underdose was given. She could have been given twice the dose, and that could have been repeated after 5 minutes - but perhaps even more importantly, it needed to be given earlier. That's the intervention that saves lives and sadly did not happen. I feel terrible for whatever pharmacist was involved in the underdosing because that really is a training issue. For whatever reason they lacked the confidence or feared giving "too much" adrenaline.
Unfortunately there is a lack of awareness/education around anaphylaxis. People do not understand that you can die from anaphylaxis (due to circulatory failure) without developing swelling around the mouth or breathing difficulty, for example (obviously these can also be signs of anaphylaxis but don't have to be present).
Anaphylaxis tends to progress in severity with each exposure. A previous history of milk exposure causing flushing and vomiting (which may also have qualified as anaphylaxis but could have been downplayed or not identified) that settled with antihistamines, may have led to false reassurance. If people do not understand the signs they may decline an EpiPen when they really need one.
Once somebody has already had an arrest, paramedics would then have to give adrenaline IV (which is a further delay) alongside effective compressions for it to have much effect, and that's obviously going to be a terrible situation that's hard to get back from. It's very important to give the adrenaline quickly to halt the process before the person completely collapses.
I believe the average time for cardiac arrest from anaphylaxis is 30 minutes without treatment if the allergen is ingested. A fit teenage may present as simply "unwell" for a lot of that vital time, walking, talking and then suddenly decompensate. It is really hard to imagine how bewilderingly fast 30 minutes is to go from totally fine to in cardiac arrest unless you've been in that situation. Hard to think straight. This is why education and training is vital so that no thinking is needed, it's just drummed in. Give the EpiPen. And if you're not sure, after 5 minutes give it again.
I feel terrible for that poor, poor girl and her mother. Allergy UK has a lot of information and have been desperately trying for a number of years to raise awareness particularly around lowering the threshold to prescribe and administer adrenaline.