For me there are two kinds of reaction. There are “lives well-lived” -people like David Bowie who just seemed to have figured life out and improved it for the rest of us. The sort of person you would want to be.
and then there are the intensely frustrating ones like Matthew Perry where I think “what’s the point of striving for love and money and admiration when this is what it does to people?” It seems to make the striving for those things a bit pointless.