I can't offer any helpful anecdata I'm afraid. In the last few months I've started taking vitamin D and a low dose of oestrogen pretty much at the same time. One or both of them seemed to pep me up and my slightly achy joints felt much better.
Then more recently I've started taking creatine, ashwagandha, and a NMM and resveratrol combo capsule, and I'm feeling pretty awesome!
I'm also having a daily coffee. I was sworn off caffeine for years as it made me so anxious and sleepless, but I'm feeling chilled enough to try it again.
I'm generally sleeping much better (although not last night. I'd forgotten to take the ashwagandha... Might be coincidence).
I'm a runner and have had so much more energy and enthusiasm for it, it's unreal! When though I enjoy running, I usually have to kind of force myself out the door, but it just seems so much easier now. My legs feel springy, and I just feel more able/willing to push harder. Got several Strava PBs on segments today.
I wish I'd taken a more methodical approach as I have no idea what's helping. Could just be the hrt? Although it's just one spray of lenzetto, and i realised today that I've been spraying the last dregs out of the bottle for the last 10 days or so. The instructions say to bin it after 56 days, which I think must be to prevent a dosage issue. The squirt has been looking noticeably smaller.
Anyway, I'm just going to have to keep everything going! 🤷