I've got 3 friends who like a bit of coke, off they toddle to the loo and nobody cares because, well, live and let live. But...
Friend1 comes back absolutely awesome, dancing, happy, confident and just a sassier version of herself, bags of energy, funny as fuck, life and soul of the party.
Friend2 is smiley and bouncy but also edgy, she's chatty but also really paranoid, constantly sniffing and looking around a bit wild eyed, dry mouth, loses control of her face a bit, drinks and smokes loads, calms down after a few minutes until next time.
Friend3 shouldn't bother. It makes her really loud and serious about deep intense things... cancer, politics, depression, finances were on the last agenda ... things I don't want to chat about on a (rare) night out. Best avoided after her first trip to the toilets.
So, different strokes for different folks I guess, no prizes for knowing which one I prefer partying with!