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Can I ask about your experiences with antidepressants?

85 replies

Coffeeisnotmycupoftea · 05/05/2026 10:06

I didn't want to put this on the Mental Health board as I assume most people on there are in my position and needing help, I wanted to ask this as an all round question to not only people in full mental health crisis right now but also those who may have found themselves on the other side and feeling well again.

I think that I need to try anti-depressants but every time I try I am wracked with fear to the point that I just can't do it. I know I need to grow up but I am genuinely paralyzed with fear.

As I type this I appreciate that it must seem ridiculous to many people and I am fully aware that it is more than likely my poor mental health talking me out of it all but I just can't do it.

It's not about the stigma of mental health medication, I honestly couldn't give a toss about that, nor is it the fear of being 'hooked' on these meds because tbh, if they were to change my life for the better I would be more than content to be on them for life.

It's how I feel now and the fear of being made to feel worse by the drugs. Anti-depressants appear to have such a reputation for awful side effects and sufferers having to push through feeling much worse before they feel better and this could be weeks to months. I just don't think I could cope feeling any worse than I already do. I have daily gut issues which completely control my life (and yes, I have tried everything else, literally everything to ease these issues), my anxious state of mind is high 24/7, I have visceral hypersensitivity so feel everything stronger than I probably should do (every ache, pain, weird sensation in my body), my health anxiety is dreadful and the worst it has ever been, not helped by the fact I am 53 and in perimenopause/menopause and have a heap of added issues including endometriosis and adenomyosis (HRT made this worse) and helping to care for an elderly parent with advanced dementia - I am exhausted and mentally spent. I am also waiting for surgery for the gynae issues and due to my heightened state of anxiety, I just don't think I can go through with it right now.

I am a hot mess, as they say. I acknowledge this and know full well that I need to make changes and have tried really hard by living as healthy a lifestyle as I can but it's doing sod all for my mental health (and physical it seems). No amount of living well, meditating, counselling and/or cbt is cutting it.

Yet I sit here staring at the bottle of fluoxetine my GP prescribed 2 months ago knowing full well it will more than likely end up in the cupboard with the out of date tablet form of Fluoxetine, the box of Citalopram from 2022, and the Amitriptyline and Sertraline because I am so terrified of any side effects especially a worsening of my gut issues which have taken over my life and made me fearful of going out in case I might suddenly need the loo etc. All the side effects list everywhere for AD state diarrhoea and nausea as the most reported side effect and I just can not risk a worsening of that (and Imodium makes my stomach issues worse before anyone suggests taking it at the same time).

I asked for the liquid form of Fluoxetine because I thought, maybe, I could go in at a really low dose and build up but even that has me in a panicky meltdown whenever I have tried to take it.

I am so fucking angry with myself......so angry.

Please tell me about your experiences with antidepressants, did they help you get a life back on track? Did they not help? Did they make you feel worse than before? Just how can I get over this overwhelming fear of the side effects? I know we are all different and each experience with antidepressants is unique but I don't know what else to do.

OP posts:
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ToadRage · 11/05/2026 12:59

I started off on citalopram and moved to fluoxitene after a little while in 2009. I relapsed in 2013 and went back on fluoxitene. I have been off the drugs for a few years and my mental health is better now than it has been in years. It always gets worse before it gets better but you need to believe it will get better. Drugs can only do so much, the rest is on you. Make the effort to do things you enjoy and see people who are positive for you. I've been there, I know how hard it is just to get out of bed but it's important that you try. Make plans, give yourself a reason to get up. Do not give in to negativity but don't be ashamed to shut yourself away and cry if you need to. You can beat this. I believe in you.

MarmadukeM · 11/05/2026 12:49

Binbag70 · 11/05/2026 09:50

Sertraline x

Thanks x

3luckystars · 11/05/2026 10:03

Well done x

bittertwisted · 11/05/2026 09:58

I take venlafaxine, it works for me taking 75mg twice a day, apparently when acts as a dual inhibitor, increasing both serotonin and norepinephrine. Anyway it has saved me, I sort of didn’t realise how much until I look back
awful insomnia for the first few weeks, but it’s settled now

Binbag70 · 11/05/2026 09:50

MarmadukeM · 11/05/2026 09:34

What medication do you take? If you don’t mind me asking x

Sertraline x

MarmadukeM · 11/05/2026 09:34

Binbag70 · 11/05/2026 09:28

I was once you, OP. I was prescribed literally everything over the years but could never get past the initial side effects and always quit after a few days. Until I got to the point when I knew I was going to be extremely unwell unless I started taking something, and then I pulled my big girl pants up and stuck with it.

Not everyone gets side effects but mine were pretty severe. Having said that, I still worked every day, still got up in the morning, etc. I have IBS and it didn’t affect that, it was more indigestion type gastro symptoms - gaviscon helped. You do feel a bit spaced out for a few weeks but it’s manageable. I remember my GP saying at one point “if you really need them, you’ll take them”. She was right. I knew I had no choice, I just wanted to get better.

Two years on and my life is completely transformed. No health anxiety, no constant ruminations, no paranoia, I’m just calm and happy and normal me again. So 2-3 weeks of discomfort and then 2 years of feeling normal. Definitely worth it!

What medication do you take? If you don’t mind me asking x

Binbag70 · 11/05/2026 09:28

I was once you, OP. I was prescribed literally everything over the years but could never get past the initial side effects and always quit after a few days. Until I got to the point when I knew I was going to be extremely unwell unless I started taking something, and then I pulled my big girl pants up and stuck with it.

Not everyone gets side effects but mine were pretty severe. Having said that, I still worked every day, still got up in the morning, etc. I have IBS and it didn’t affect that, it was more indigestion type gastro symptoms - gaviscon helped. You do feel a bit spaced out for a few weeks but it’s manageable. I remember my GP saying at one point “if you really need them, you’ll take them”. She was right. I knew I had no choice, I just wanted to get better.

Two years on and my life is completely transformed. No health anxiety, no constant ruminations, no paranoia, I’m just calm and happy and normal me again. So 2-3 weeks of discomfort and then 2 years of feeling normal. Definitely worth it!

TaraRhu · 11/05/2026 09:19

Try them. They have saved my life many times. Yes, you might get some side effects at first but they level out. I don't buy that they numb you. That's rubbish. They make you see things at a normal level. Not spiralling into anxiety after a friend doesn't text back for example. Anti ds let me feel joy. They might not work for everyone but they worked for me. Therapy alongside will help too.

There's a lot of judgement around anti depressants. People saying they are a placebo, addictive, overprescribed but that's really unfair. Yes , in some cases this may be true but for others they make a huge difference .

Coffeeisnotmycupoftea · 11/05/2026 08:41

wandawaves · 11/05/2026 00:44

Well done OP! This is a great start.
And yes you are probably extra anxious because you are anxious! Not because of the meds.
Do try and continue. Remind yourself of what you will be able to do if it is successful; think about proudly being able to take your daughter on a shopping trip soon!

Thank you so much.

OP posts:
wandawaves · 11/05/2026 00:44

Well done OP! This is a great start.
And yes you are probably extra anxious because you are anxious! Not because of the meds.
Do try and continue. Remind yourself of what you will be able to do if it is successful; think about proudly being able to take your daughter on a shopping trip soon!

unsync · 10/05/2026 18:19

Venlafaxine for anxiety. One week of feeling extremely nauseous, next week slightly queasy, by the third week everything settled and I just felt nothing. No anxiety, no panic, just flat. It enabled me to start functioning at a very basic level.

Coffeeisnotmycupoftea · 10/05/2026 09:12

So I decided to not take a SSRI but to try Nortriptyline again. I had trialled to for a very short time last year but chickened out a few days in as I was so worried about side effects.

I've chosen this meds because amongst everything that is currently going on in my life right now I'm finding the IBS, upper gut issues and visceral hypersensitivity is ruining my life atm, I can't work or even pop to the shops without feeling I need the loo and I will get into a huge panic about it. I couldn't even join my daughter in London for her 18th birthday shopping trip last week due to the overwhelming fear (luckily she ended up having a great day with a friend).

I started with half a10mg tablet per day 2;days ago. I feel weird and extra anxious but at 5mg I'm not sure if that's more me and the anxious state I'm already in rather than the meds? But I'm determined to get through the next couple of weeks on 5mg then up to the prescribed 10mg.

I'm scared, apprehensive and on edge waiting for a side effect that will completely freak me out but I'm desperately hoping if I can settle my digestive system I can then work with a therapist for my anxiety (currently on a waiting list for specialist CBT). I'm also looking into a course of acupuncture to help with all my physical issues which do drive the anxiety.

That's the current plan/hope.

Thank you all for your help and advice and for those still in the deep.kf this too, I hope all.fows well.for.you.

OP posts:
Coffeeisnotmycupoftea · 10/05/2026 08:59

Mimilamore · 10/05/2026 07:36

Just to update, I carried on taking sertraline but went to 50mg every day rather than every other as was suggested on here.
I’m 6 days in now…. feel a bit groggy in the mornings and have mild nausea which wears off after a couple of hours. Strange teeth chattering at times but this is getting less, bit of a headache. Nothing too bad…
I’m going to continue as have got this far and would rather this than how I felt before in the hope that better days lie ahead.

Good luck with the journey and I hope things really start to improve for you soon.

OP posts:
Lemonthyme · 10/05/2026 07:58

I was on Citalopram years ago.

I'm very wary typing this because I do know some people have their lives saved by SSRIs but for me, they were one of the worst decisions I've ever made. But I am not you.

I'll describe my situation and then you can take or leave it on if you think it applies to you or not. Mental, like physical health is incredibly personal. Trigger warning for some of this content.

I had severe anxiety from childhood which I now recognise was due to emotional abuse. That took a lot of therapy to recognise. That was then exacerbated by trauma at the age of 21 (and some instances since). Basically I was the victim of a stranger rape.

C. 10 years after I had what many used to call "a breakdown" and that's when Citalopram was prescribed. For me it made me numb but didn't numb me for the worst feelings and while on it I started self harming and attempted suicide.

So I cannot say it helped me. Depression for me always had good days or perhaps just hours. Citalopram took them away and made the world grey. Then when coming off it, it gave me these horrible "electric shock" type side effects. Only lasted a week or so but I was never warned.

What helped me was therapy. EMDR for the trauma and a combination of CBT and psychodynamic therapy for anxiety. Much of that I paid for myself but was worth every penny. I also read a lot of self help books. Look I know, much derided but I found "A Man's Search for Meaning" and "Lost Connections" both super helpful. They both changed my life in a way that what I was missing was my "why" to live. A purpose. Not necessarily a big hairy goal but the small things that give you connection and make life meaningful. I changed my work, my relationship (not suddenly, this all took years) and I'm happier for it. I also became a mental health first aider and in a small way started to assimilate my experiences into me. Accept my trauma and recognise that because of it, not despite it, it gave me something I could offer others.

There is a story in Lost Connections I like. It's all about a rice farmer injured in Vietnam due to an unexploded bomb. The doctor prescribed a cow. The reason being that the cow would give him a source of income and a purpose. The doctor described that as an "antidepressant" and to me that made total sense.

I'm not saying "don't" to antidepressants because especially if you cannot seek therapy or have no energy for it, it might be the right answer for you right now. But as you asked for honest opinions, this is mine, from my sample of one.

Mimilamore · 10/05/2026 07:36

Just to update, I carried on taking sertraline but went to 50mg every day rather than every other as was suggested on here.
I’m 6 days in now…. feel a bit groggy in the mornings and have mild nausea which wears off after a couple of hours. Strange teeth chattering at times but this is getting less, bit of a headache. Nothing too bad…
I’m going to continue as have got this far and would rather this than how I felt before in the hope that better days lie ahead.

PoppySeedBagelRedux · 07/05/2026 06:18

I had depression years ago after getting breast cancer quite young. The depression was bad enough that I couldn’t work. I was on anti depressants for a while and they helped me. I came off them quite quickly (a year I think) and started using St John’s Wort, and then came off that and have been fine ever since.

spm20 · 07/05/2026 05:42

I recently started taking antidepressants for the first time while postpartum. My biggest fear was feeling worse then I already feel but I already felt dreadful and the hope of feeling better made me take them. I felt just as bad as I did maybe slightly worse for a week and then I felt so much better. I thought I would only take them for a while but I’ve seen such an improvement in myself and people around me have noticed how much more happier and chilled out I am. The only negative for me is that my appetite has increased and I have put on weight but the mental health benefits outweigh the weight gain which I now have motivation to do something about.

3luckystars · 06/05/2026 18:32

You stomach issues might be caused by anxiety.

Would you consider trying it for a month. You can come off them if it doesn’t suit you. I know that sounds easy but it is. Get all the support you need in place and plough ahead for a month. It’s worth a shot.

ChickensAndEggs · 06/05/2026 17:29

Coffeeisnotmycupoftea · 06/05/2026 16:46

My main concerns are nausea and bad diarrhoea. I have these symptoms daily as it is and they completely control my life, the idea that an antidepressant could exacerbate this really holds me back from trying. I see time and again people saying they were stuck on the loo with a bad tummy as a result of their AD. I can't counteract this side effects with something like imodium as I have bad reactions to that med so I'd have to ride it through which I honestly don't think I could do.

I also worry they will give me headaches especially a worsening of my aura migraines, which after 20 years of suffering from still scared the life out of me.

I really feel for you OP and you sound desperate to feel better.

Honestly, all the side effects you mention here are very short term. And are unpleasant but not in anyway life threatening. It’s not like you are worried about long term risks which might not reveal themselves for years. If you try the medicine and you get side effects and you feel the benefit doesn’t outweigh the risk, you can stop and the side effects will stop.

On the other hand, perhaps you will find that your gut issues and migraines improve if the ADs help your state of mind. In all honesty I think this is more likely than that you will suffer from bad side effects.

eta Please don’t take this as me minimising how awful migraines in particular can be. I’m really not, but the effect of your mental state of mind on your life sounds awful too, and as I say, perhaps you will see an improvement rather than a worsening.

SagathaChristie · 06/05/2026 17:15

ChickensAndEggs · 06/05/2026 12:27

It’s rarely a dramatic shift.

Couldn’t disagree more. Obvious they have different effects in different people, depending on many factors. But you can read many people on MN saying that ADs have saved their lives. They certainly saved mine during a terrible time when I was completely loosing it and a high dose helped me survive.

On a more day to day level (I have been on them for 20+ years and have tried coming off them enough times to be confident of the effect) they stop me being completely unable to cope and unable to enjoy anything to being a functioning person who, whilst life is hard, can find enjoyment and joy in life.

I agree about the side effects though, many people don’t experience any.

They say that ADs have the most noticeable effect on people with severe symptoms.

Touty · 06/05/2026 16:57

wandawaves · 06/05/2026 15:18

But I mean... does that matter?
Is it a problem to stay on them long term?

I'm not bothered at all about mine being long term, I just take the tablet every day, same as I take my statin and blood pressure tablets.

I think it does matter, they do change your brain, so it’s hard to come off them when you’ve been on them for years.

Ive tried for years to come off them as I can’t orgasm on them sorry to be blunt.

Coffeeisnotmycupoftea · 06/05/2026 16:47

wandawaves · 06/05/2026 15:18

But I mean... does that matter?
Is it a problem to stay on them long term?

I'm not bothered at all about mine being long term, I just take the tablet every day, same as I take my statin and blood pressure tablets.

No, if they worked for me I can't see that I'd want to come off them but my sister has been advised because she may have a heart issue potentially caused by the meds and she's having issues weaning off. Id hate that.

OP posts:
Coffeeisnotmycupoftea · 06/05/2026 16:46

ChickensAndEggs · 06/05/2026 12:33

OP what side effects are you particularly worried about?

My main concerns are nausea and bad diarrhoea. I have these symptoms daily as it is and they completely control my life, the idea that an antidepressant could exacerbate this really holds me back from trying. I see time and again people saying they were stuck on the loo with a bad tummy as a result of their AD. I can't counteract this side effects with something like imodium as I have bad reactions to that med so I'd have to ride it through which I honestly don't think I could do.

I also worry they will give me headaches especially a worsening of my aura migraines, which after 20 years of suffering from still scared the life out of me.

OP posts:
wandawaves · 06/05/2026 15:18

Coffeeisnotmycupoftea · 06/05/2026 08:32

That has been one of my fears, both my sister and best friend are on Sertaline and say they feel they can't come off them.

But I mean... does that matter?
Is it a problem to stay on them long term?

I'm not bothered at all about mine being long term, I just take the tablet every day, same as I take my statin and blood pressure tablets.

ChickensAndEggs · 06/05/2026 12:33

OP what side effects are you particularly worried about?