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Feminism: Sex and gender discussions

Why the NHS puberty blocker trial is appalling

1000 replies

Soontobe60 · 16/11/2025 14:43

Stella O’Malley from Genspect telling it like it is - that a state endorsed trial of puberty blockers for gender dysphoric children should NOT go ahead.
the NHS are not walking into this nightmare blindly - there are enough experts out there telling them what will happen happen to these children if they’re given these life changing drugs.
https://x.com/genspect/status/1989896741358113127?s=61&t=gKvvk-rWmOlYFGMZN8QVvQ

Genspect (@genspect) on X

In a conversation about the Next Generation, podcast host Elliot Bewick @elliotbewick talks with @stellaomalley3 : “This won't be puberty because their reproductive system won't be awakened, it will be a chemical insurgents into their body…and so they...

https://x.com/genspect/status/1989896741358113127?s=61&t=gKvvk-rWmOlYFGMZN8QVvQ

OP posts:
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82
ArabellaSaurus · 23/11/2025 11:44

TheWeightOfTheWorld · 23/11/2025 10:41

How many children are to be enrolled on the trial in total? How much sensible counselling/therapy/non-clinical support would £10,000,000 buy in terms of hours? How many children could be supported for that kind of money?

There are a few trials running concurrently. Overall, there are several thousand children involved, but the puberty blocker trial anticipates a very precise number - 226 iirc - which suggests to me they have already selected candidates.

MrsOvertonsWindow · 23/11/2025 11:45

TwoLoonsAndASprout · 23/11/2025 11:39

Thank the ever loving fuck for that.

In addition to this, all the organisations fighting this - Transgender Trend, Sex Matters, Safe Schools Alliance, LGB Alliance & countless others are fully up to speed and networking with access to top quality legal advice.

The NHS / the State abusing children in this way are no longer able to do so in secret.

TheKeatingFive · 23/11/2025 11:46

Seems to be the only way forward unfortunately. Fight this tooth and nail at every, single point.

ArabellaSaurus · 23/11/2025 11:48

TwoLoonsAndASprout · 23/11/2025 10:56

Kiera has an op ed at the end of yesterday’s Telegraph article. Copying here:

A conveyor belt to lifelong harm
By Keira Bell
In 2020 I became a claimant in a Judicial Review against The Tavistock’s Gender Identity Development Service (GIDS) to challenge the idea that under-18s could provide informed consent for puberty blockers. The High Court ruled that it was highly unlikely for a child aged 13 or under to provide informed consent, it was doubtful that 14 and 15-year-olds could, and that those over 16 should be referred to the courts if there is any doubt about their capacity to consent.
Despite this ruling being overturned in the Court of Appeal on a point of law, this process exposed the insanity that was taking place not only at The Tavistock but across the Western world.

Now, the nation is about to commence hundreds of under-16s on a puberty blocker trial. They claim this is to gain the evidence to inform clinical practice. However, I and many others believe this to be a deeply unethical, disgusting experiment on the children of this nation.

A “trial” of puberty blockers has already been conducted. In 2011, GIDS and University College London Hospitals (UCLH) studied 44 children between 12 and 15 over three years – the “early intervention study”. They kept the findings in the dark until the 2020 court proceedings forced them to reveal this information.

What was revealed was that – at best – the blockers did nothing to improve children’s mental health.

For some, it worsened. I am a testament to this. It sent me into a menopause-like state: hot flushes, brain fog, worsened depression, anxiety and my bone density drastically decreased. It did not provide a “pause” to think and reflect like these doctors claim.

In fact, I became more desperate to start cross-sex hormones (testosterone) and escape the compounded hell I was experiencing, which I did a year later. I also went ahead with a double-mastectomy at age 20. I am included in the statistic of 98 per cent of children who proceed further down the pathway once they are initiated on puberty blockers.

I suffered at the age of 16 and I can only imagine the level of physiological damage that these children – who are younger than I was – will experience if this trial goes ahead. It is rightly described as a conveyor belt that will undoubtedly lead to infertility and lack of sexual function, to name only a couple.

A child cannot fully understand these effects, let alone those that are unknown. Puberty is the antidote to gender dysphoria for 85 per cent of children, who reconcile with their sex when they are left alone. Many of these children have mental health comorbidities, are autistic and/or same-sex attracted. They deserve holistic treatment and to lead happy, fulfilling lives. Not to be made life-long medical patients, coupled with a life of confusion and disorientation.

Puberty does not happen in a vacuum. It is not some magical process isolated from the rest of the body. Neil Evans’s trial on sheep revealed that memory and cognition was impaired from puberty blockers and their cognition did not recover once ceased.

UCLH told me they were reversible when I signed the form. The ideologically captured NHS itself lied on its guidance and stated these drugs are reversible until the 2020 ruling forced them to reflect the facts – we don’t know.

Yes, puberty blockers are prescribed for precocious puberty – a developmental abnormality. They are also used to chemically castrate adult sex offenders. It is inexcusable to inject this substance into vulnerable children who are experiencing a complex psychological issue, when they are likely to recover without it.

The horrifying concept of providing puberty blockers to children was originally created and tailored for boys, where this process was to allow them to ‘pass’ as a woman later in life. This, of course ignoring all the negative, life-altering effects.

However, most patients diagnosed with gender dysphoria for the past 10-plus years have been female, where puberty blockers are unnecessary to “pass” as men. Not only is the prospect of a trial negatively life-altering, but it lacks any superficial benefits.

Why are we not utilising the evidence we already have? Did those of us who already had this treatment do it in vain?

Puberty is rough for everyone, but it is necessary.

https://www.telegraph.co.uk/gift/8928696e3bd3fac5

Eloquent and moving.

Also note Keira started PBs at 15 and had a mastectomy at 20, before 'detransitioning'.

The arc seems to play out over a period more like 7-8 years, so a 1 or 2 year study is pointless.

ProfessorDameFarriersGirl · 23/11/2025 11:51

MrsOvertonsWindow · 23/11/2025 11:37

James Esses & Keira Bell apparently have the funding in place to mount a Judicial Review against this monstrous experiment on children:

https://x.com/JamesEsses/status/1992502486184398990

Thank you! I'm sort of relieved but still quite anxious about the outcome.

teawamutu · 23/11/2025 11:55

I'm also anxious - judicial review hasn't been the most effective route for GC cases in the past. I hope I'm wrong on this one.

TheWeightOfTheWorld · 23/11/2025 11:56

ArabellaSaurus · 23/11/2025 11:44

There are a few trials running concurrently. Overall, there are several thousand children involved, but the puberty blocker trial anticipates a very precise number - 226 iirc - which suggests to me they have already selected candidates.

Thanks. Do you know if the £10,000,000 is just being spent on the puberty blocker trial or does it cover funding all the parallel trials?

TwoLoonsAndASprout · 23/11/2025 12:06

MrsOvertonsWindow · 23/11/2025 11:45

In addition to this, all the organisations fighting this - Transgender Trend, Sex Matters, Safe Schools Alliance, LGB Alliance & countless others are fully up to speed and networking with access to top quality legal advice.

The NHS / the State abusing children in this way are no longer able to do so in secret.

I presume that if they need the mighty elbow of the vipers of MN we will hear? Because I feel there are many of us who would be prepared to throw our amateur researching/petition signing skills behind this.

eta: and carrots, obvs

PrettyDamnCosmic · 23/11/2025 12:07

ArabellaSaurus · 23/11/2025 11:44

There are a few trials running concurrently. Overall, there are several thousand children involved, but the puberty blocker trial anticipates a very precise number - 226 iirc - which suggests to me they have already selected candidates.

I have only skimmed the trial protocol but this precise number of 226 subjects will be the number that the complicated stats equations have calculated is the minimum number required to produce a statistically significant result. This will be the minimum number that they need to recruit.

EasternStandard · 23/11/2025 12:11

Shedmistress · 23/11/2025 11:38

https://x.com/JamesEsses/status/1992148590018666845

From James' x:

The trial has been quietly approved and recruitment of hundreds of children is commencing. Keira Bell and I demand that this dangerous and unethical trial is halted immediately. If it isn’t, we will bring a Judicial Review.

Please be the case. Just stop this happening.

RedToothBrush · 23/11/2025 12:30

ArabellaSaurus · 23/11/2025 11:48

Eloquent and moving.

Also note Keira started PBs at 15 and had a mastectomy at 20, before 'detransitioning'.

The arc seems to play out over a period more like 7-8 years, so a 1 or 2 year study is pointless.

The average length of time that people spend in a cult is seven years. It is strange to see that repeating. We also know that in Chinese astrology they break down life into 7 stages that largely last about seven years...

Tootsweets23 · 23/11/2025 12:35

There goes Wes Streeting’s attempt to be prime minister. His whole thing is being captain sensible against the purple haired weirdos, and yet here he is endorsing vivisection on gay and autistic kids.

ArabellaSaurus · 23/11/2025 12:38

PrettyDamnCosmic · 23/11/2025 12:07

I have only skimmed the trial protocol but this precise number of 226 subjects will be the number that the complicated stats equations have calculated is the minimum number required to produce a statistically significant result. This will be the minimum number that they need to recruit.

Thank you, that's very helpful. I did wonder!

ArabellaSaurus · 23/11/2025 12:44

For completeness, here are all the assessments to be used on the Trial. I'm not putting the other strands of the programme, jsut the PB trial:

13.1.1

Primary Outcome

  1. The primary outcome for the PATHWAYS TRIAL is the quality of life of children referred to national gender services for young people in the UK, measured using the CYP self-report version of the KIDSCREEN-10 questionnaire.

13.1.2 Secondary Outcomes

13.1.2.

1 Scales of Gender-Related Distress, Mental Health Symptoms and Physical Health measures :
a. Utrecht Gender Dysphoria Scale – Gender Spectrum (UGDS-GS)
b. Revised Children’s Anxiety and Depression Scale (RCADS)
c. Body Image Scale – Gender Spectrum (BIS-GS)
d. Parental Attitudes of Gender Expansiveness Scale for Youth (PAGES-Y)
e. SCOFF questionnaire
f. Sexual attraction questionnaire
g. ALSPAC measure
h. Gender identity question
i. Adolescent Primary Care Traumatic Stress Screen (APCTSS)
j. KIDSCREEN-52
k. Height (cm) and weight (kg)
l. Physical health diagnoses

13.1.3 Scales of Suicidal Ideation, Hospitalizations, Mood Symptoms, Behavioural and Functional Difficulties:

a. Ask Suicide-screening Questions (ASQ)
b. Child Behaviour Checklist (CBCL)
c. Youth Self-Report (YSR)
d. Difficulties in Emotion Regulation Scale – 18 (DERS-18)
e. Hospitalisations of participants

13.1.4 Experiences of Therapeutic Options:

a. Rates of referral to, uptake of, and completion of psychological therapy, occupational therapy, speech and language therapy, clinical nursing, youth work support, school/college support, and non-endocrine pharmacological treatments.

13.1.5 Cognitive Assessments
a) Wechsler Intelligence Scale for Children (WISC-V)
b) Delis-Kaplan Executive Function System (D-KEFS)
c) Child and Adolescent Memory Profile (CHAMP)
d) Memory Validity Profile (MVP)
e) Behaviour Rating Inventory of Executive Function (BRIEF)

13.1.6 Continuous Physical Measures
a) Height (cm)
b) Weight (kg)
c) BMI
d) Bone mineral density (DEXA) z score
e) Blood pressure; systolic, diastolic, mean
f) Safety bloods

13.1.7 Binary Physical Outcomes

a) Adverse events
b) Puberty staging (Tanner staging, both clinical and self-reported)

ArabellaSaurus · 23/11/2025 12:44

ArabellaSaurus · 23/11/2025 12:38

Thank you, that's very helpful. I did wonder!

Sample size justification:

'13.4.1 Trial The anticipated sample size is approximately 226 participants. This sample size is based on the expected eligible clinic prevalence of gender-related distress, allowing for sufficient power to estimate the posterior distributions of treatment effects and to detect meaningful differences and associations in the primary and secondary outcomes. Using simulations, it was determined that with 226 participants the trial would have the equivalent of 91% power with a standardised effect size (SES) of 0.525. For the primary outcome, the SES of 0.525 means a difference of 5.25 points on the standardised KIDSCREEN-10 t-score, where the standard deviation is 10 for all t scores at all timepoints. If recruitment is lower than expected, the probability of detecting the same SES will be lower. If only 150 participants are recruited, the trial would still have the equivalent of 80% power to detect the SES of 0.525. As the eligibility criteria for the trial cannot be changed or widened as would be common in a poorly recruiting trial, nor more sites added, other options would have to be considered to reach the target sample size of 226. This could include extending the recruitment period and therefore timeline for the trial. Interim analyses can also be carried out at pre-specified points where decisions on the continuation of the trial can be taken. All amendments to the trial will be approved by both the DMC and the PSC committees before being enacted.'

TheKeatingFive · 23/11/2025 12:47

I feel a bit for Streeting tbh. I think people like him didn't realise how deeply entrenched this stuff is in his party and the nhs.

OpheliaWitchoftheWoods · 23/11/2025 12:55

Shedmistress · 23/11/2025 11:38

https://x.com/JamesEsses/status/1992148590018666845

From James' x:

The trial has been quietly approved and recruitment of hundreds of children is commencing. Keira Bell and I demand that this dangerous and unethical trial is halted immediately. If it isn’t, we will bring a Judicial Review.

Quietly. Isn't it amazing how all of this has to be done under the radar, without transparency or facing up to the resistence against this? Not explained, not justified, those points and concerns not addressed, just sneaked through. So much of this entire mess was achieved through dishonesty because it was known it would not survive daylight and scrutiny.

And again - years of fuss and anxiety and risk assessments and cost assessments and flapping and handwringing about keeping men out of women's toilets according to law..... but this? Whizzed through in an instant with all barriers vanished.

My God, how hard the establishment will work and the mountains they will move when it comes to men in dresses.

Cantunseeit · 23/11/2025 12:55

I was out and about yesterday doing nice normal things, so still catching up on this thread and have got to @ArabellaSaurus posts with FAQs / questionnaire and just need to register my howl of outrage and distress here.

I can’t write anything coherent yet but feel I need to add my voice to the others here. We are truly in the upside down aren’t we?

I will write to my MP and ask for my position to be raised with Wes S when I’m able.

Any other action we can take? (Thanks Arabella for the FOI)

Signalbox · 23/11/2025 13:14

ArabellaSaurus · 23/11/2025 11:44

There are a few trials running concurrently. Overall, there are several thousand children involved, but the puberty blocker trial anticipates a very precise number - 226 iirc - which suggests to me they have already selected candidates.

Which in itself would be immoral. I assume it’s possible that the experiment won’t be able to proceed until any court challenges are completed so those children will have been promised something that they may not be able to participate in if they pass the upper age limit by the time it actually starts.

ArabellaSaurus · 23/11/2025 13:18

Signalbox · 23/11/2025 13:14

Which in itself would be immoral. I assume it’s possible that the experiment won’t be able to proceed until any court challenges are completed so those children will have been promised something that they may not be able to participate in if they pass the upper age limit by the time it actually starts.

My assumption was wrong, see post above.

ScrollingLeaves · 23/11/2025 15:32

WhyThatsDelightful · 22/11/2025 21:28

Obvs ‪children in care will be excluded from this trial. Because it would be immoral if they are not, or perhaps just an easy way to get the numbers for the trial

open.substack.com/pub/juliebindel/p/why-do-so-many-girls-in-blackpool?r=8yvse&utm_medium=ios

Does anyone know if all the trial subjects will have been screened/eliminated not only for being in care, but also for autism, trauma and homophobic parents?

LikeAHandleInTheWind · 23/11/2025 15:42

One of the disturbing items in the trial protocol is that any UK nation participating will be commissioning a new NHS pathway so children enrolled in this trial can have the option of continuing puberty blockers and going onto cross sex hormones at the end of their study participation. This is very much restarting the Tavistock conveyor belt of puberty blockers then cross sex hormones - entirely unstudied in animals as far as I can tell.

Thei

ScrollingLeaves · 23/11/2025 16:08

ProfessorBettyBooper · 22/11/2025 17:48

Thank you for this. This is another horrendous aspect I hadn't considered.

And this:

(For boys, they have to be able, which might prove difficult if they hate their bodies, to provide sample(s) of healthy sperm.)

A boy of 11 or 12 (or any age actually) being asked to do this, regardless of their feelings about their body, makes me feel ill.

In the case of cancer, where it is unavoidable, I can understand it, but for the sake of this monstrosity, it is child abuse. What the hell are these people thinking??

A boy of 11 or 12 (or any age actually) being asked to do this, regardless of their feelings about their body, makes me feel ill.

It is actually abusive imo.

ArabellaSaurus · 23/11/2025 16:11

'Pregnancy tests will only be conducted in TRIAL participants of child-bearing potential. '

😶

ArabellaSaurus · 23/11/2025 16:18

https://www.transparimed.org/single-post/pathways-trial-of-puberty-blockers-for-transgender-youth-where-is-the-protocol

'Refusal to release the trial protocol

The Health Research Authority (HRA), the central body overseeing ethics approvals for clinical trials in the UK, has refused to make the trial protocol public at this stage, a Freedom of Information request response shared with TranspariMED by a campaigner shows.

According to the HRA:

“In this instance, we have concluded that the public interest in withholding the information until its planned publication, combined with the likelihood of prejudice, outweighs the public interest in immediate disclosure.”'

PATHWAYS trial of puberty blockers for transgender youth: Where is the protocol?

The UK is poised to soon launch a landmark trial of puberty blockers for transgender youth to “to find out how the [National Health Service] can best support children and young people with gender incongruence”. The trial has already been funded with pu...

https://www.transparimed.org/single-post/pathways-trial-of-puberty-blockers-for-transgender-youth-where-is-the-protocol

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