I'm finding it hard to get my head around this. It just shows how powerful this medication is.
https://abstracts.eurospe.org/hrp/0097/hrp0097p2-91?s=09
Case description: A 3-year-old girl was referred to our pediatric outpatient clinic with breast development and vaginal discharge over a period of 6 months. The GAHT of her transgender father was estradiol spray 6.12 mg applied to both forearms daily. After 6 months this was changed to estradiol gel 3.75 mg daily for 7 months. The gel was manually applied to the chest, abdomen, shoulders, and thighs. The father reported skin to skin contact on a daily basis. A physical examination of the girl revealed a Tanner stage III for breast and Tanner stage I for pubic hair development.