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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Previously came off mounjaro due to vomiting - try again or try Wegovy?

9 replies

weightlossmed · 02/08/2026 14:22

Does anyone have any advice or have a similar experience? Are there any prescribers that are good at offering support/medication for sickness/nausea?

Some more background below:
I took Mounjaro around 2 years ago, but after going up to 5 mg I was vomiting every morning and felt unable to continue so I came off it. About a month later I tried to go on it again and restart on 2.5 mg with the intention of staying on 2.5 mg indefinitely, but I was vomiting again as if my body had now become sensitised to it. In retrospect I wasn't doing all I could to deal with the nausea and vomiting - I didn't ask my prescriber for antisickness medication and didn't make sure I was eating and drinking enough. The medication was still relatively new so I think I was anxious about it, I remember thinking that it feels like I've been poisoning myself.

It's now been 2 years and I am considering trying again. I do still have a strong aversion to even the thought of injecting Mounjaro again; anything that reminds me of it makes me nauseous like the smell of alcohol wipes. But I'm struggling with my weight...

I'm not sure whether to try the Wegovy tablet as I wouldn't have the association of injection=vomiting, but I have heard the side effects are more extreme with Wegovy versus mounjaro, and also with the Wegovy tablet versus the Wegovy injection.

Thank you

OP posts:
lindanovak · 02/08/2026 14:27

If you were not eating or drinking enough that is likely to be the cause of the problem. I would say absolutely try again but be conscious to fuel and hydrate your body properly.

stealthsquirrelnutkin · 02/08/2026 16:30

Perhaps you should wait until Retatrutide becomes available, and in the meantime start eating and exercising as if you had just started the injections.

Making a point of carefully planning your daily meals so that they are within your required calorie deficit, and will improve your gut microbiome while meeting your fibre and protein needs.

The Zoe food science podcasts are a good starting point when you want to shed excess fat without damaging your health. If your gut microbiome is typical of someone raised on the average UK diet it will be working against you. You can gradually get it onside by fasting for at least 12- 14 hours every day, eating the widest possible variety of different plants, ensuring you get all the healthy oils and phytonutrients as well as fermented foods and all the soluble fibre that beneficial microbes need to thrive.

You also need to get into the habit of regular resistance training, to preserve muscle and bone strength during weight loss.

With your eating and exercise routines embedded you'll be in a much better place to start making other changes.

When you are ready to make another attempt, try to remember that the human brain is so powerful that a significant percentage of people in the placebo group of GLP-1 trials actually managed to vomit due to the nocebo effect. So indulging in thoughts of "poisoning yourself" with the injections is not going to do you any favours.

Instead, whenever you feel those undermining and destructive thoughts surfacing, ignore them and concentrate on all the benefits of finally being able to lose fat and keep it off, and remember that the injections lower inflammation levels in your body and are working throughout your system to improve your health.

I've been on Mounjaro since 2024. The only times I've ever felt queasy is when I'm distracted and forget to eat because unexpecting events have disturbed my routines.

As soon as I notice that seasick feeling I put the kettle on, because a mug of ginger tea, a handful of nuts a portion of dried fruit with a square of dark chocolate provides an almost instantaneous fix.

When I'm going to be away from home I make up snack bags to take with me. Each bag contains 15g of nuts (almond, hazelnut, walnut, pecan, Brazil, cashew, peanut, Macadamia or pistachio) with a portion of dried fruit (goji berries, dried black mulberries, dried chopped apricots, raisins, mango, dates, figs, prunes etc) and a single square of Lindt 90% chocolate (or Montezuma's absolute black if I'm feeling butch) and a an assortment of teabags (black, green, purple, Oolong, ginger, mint, chamomile are favourites).

That way if I start to feel hungry and the next meal is still not approaching the horizon I put the kettle on and offer to share my snacks.

weightlossmed · 02/08/2026 21:23

lindanovak · 02/08/2026 14:27

If you were not eating or drinking enough that is likely to be the cause of the problem. I would say absolutely try again but be conscious to fuel and hydrate your body properly.

Thank you, I think I'll give it another go!

OP posts:
weightlossmed · 02/08/2026 21:26

stealthsquirrelnutkin · 02/08/2026 16:30

Perhaps you should wait until Retatrutide becomes available, and in the meantime start eating and exercising as if you had just started the injections.

Making a point of carefully planning your daily meals so that they are within your required calorie deficit, and will improve your gut microbiome while meeting your fibre and protein needs.

The Zoe food science podcasts are a good starting point when you want to shed excess fat without damaging your health. If your gut microbiome is typical of someone raised on the average UK diet it will be working against you. You can gradually get it onside by fasting for at least 12- 14 hours every day, eating the widest possible variety of different plants, ensuring you get all the healthy oils and phytonutrients as well as fermented foods and all the soluble fibre that beneficial microbes need to thrive.

You also need to get into the habit of regular resistance training, to preserve muscle and bone strength during weight loss.

With your eating and exercise routines embedded you'll be in a much better place to start making other changes.

When you are ready to make another attempt, try to remember that the human brain is so powerful that a significant percentage of people in the placebo group of GLP-1 trials actually managed to vomit due to the nocebo effect. So indulging in thoughts of "poisoning yourself" with the injections is not going to do you any favours.

Instead, whenever you feel those undermining and destructive thoughts surfacing, ignore them and concentrate on all the benefits of finally being able to lose fat and keep it off, and remember that the injections lower inflammation levels in your body and are working throughout your system to improve your health.

I've been on Mounjaro since 2024. The only times I've ever felt queasy is when I'm distracted and forget to eat because unexpecting events have disturbed my routines.

As soon as I notice that seasick feeling I put the kettle on, because a mug of ginger tea, a handful of nuts a portion of dried fruit with a square of dark chocolate provides an almost instantaneous fix.

When I'm going to be away from home I make up snack bags to take with me. Each bag contains 15g of nuts (almond, hazelnut, walnut, pecan, Brazil, cashew, peanut, Macadamia or pistachio) with a portion of dried fruit (goji berries, dried black mulberries, dried chopped apricots, raisins, mango, dates, figs, prunes etc) and a single square of Lindt 90% chocolate (or Montezuma's absolute black if I'm feeling butch) and a an assortment of teabags (black, green, purple, Oolong, ginger, mint, chamomile are favourites).

That way if I start to feel hungry and the next meal is still not approaching the horizon I put the kettle on and offer to share my snacks.

Thank you for such a thoughtful reply! I'll definitely look into the ZOE podcasts. I like the idea of having a go-to snack to eat when nausea hits so I don't even have to think about it.

'Instead, whenever you feel those undermining and destructive thoughts surfacing, ignore them and concentrate on all the benefits of finally being able to lose fat and keep it off, and remember that the injections lower inflammation levels in your body and are working throughout your system to improve your health.' - this is SO helpful and has shifted my mindset. I did have some nerves with Mounjaro and the unknown when I took it in 2024, but now the research coming out shows how many benefits it has so I need to focus on that.

OP posts:
BerfyTigot · 03/08/2026 10:01

I'm 4 weeks into my second attempt after giving up due to vomiting and diarrhoea.

I spent 3 months trying to improve my gut health before the 2nd attempt - took Symprove and avoided ultra-processed foods.

I'm also now taking Cyclizine (anti emetic) and it's definitely improved (though have still vomited).

I've now reduced my dose to 1.25, against my provider's advice and that seems to be a good balance between reducing food noise and fewer side effects.

Worth another try @weightlossmed - good luck!

Newventures · 03/08/2026 10:11

I’ve been taking Ozempic over a year and I do think there’s a psychological / Pavlov type thing that has happened where I feel an extreme wave of nausea when I think of injecting, when I open the fridge door, when I see the packaging of my medication. Not sure how to help that! I reduced the dose of my medication and it helped but that nausea is still there easily triggered. Eating consistently helps.

weightlossmed · 03/08/2026 13:06

BerfyTigot · 03/08/2026 10:01

I'm 4 weeks into my second attempt after giving up due to vomiting and diarrhoea.

I spent 3 months trying to improve my gut health before the 2nd attempt - took Symprove and avoided ultra-processed foods.

I'm also now taking Cyclizine (anti emetic) and it's definitely improved (though have still vomited).

I've now reduced my dose to 1.25, against my provider's advice and that seems to be a good balance between reducing food noise and fewer side effects.

Worth another try @weightlossmed - good luck!

Thank you for the reply. I think I'll try again and try the 1.25 mg dose like you are as I do think I'm sensitive to the drug. Did you receive cyclizine from your prescriber? I'm thinking of asking for it to be prescribed straight away but not sure whether that's something pharmacies would provide? I've heard Voy give antiemetics so I might go with them initially, even though they are more expensive.

OP posts:
weightlossmed · 03/08/2026 13:09

Newventures · 03/08/2026 10:11

I’ve been taking Ozempic over a year and I do think there’s a psychological / Pavlov type thing that has happened where I feel an extreme wave of nausea when I think of injecting, when I open the fridge door, when I see the packaging of my medication. Not sure how to help that! I reduced the dose of my medication and it helped but that nausea is still there easily triggered. Eating consistently helps.

Yeah it's definitely a conditioned response. Maybe I should eat a square of chocolate every time I inject to put me off chocolate for life - that would aid my weight loss even more lol

OP posts:
BerfyTigot · 03/08/2026 13:18

@weightlossmed yes, I'm with Voy this time as they send cyclizine with the
first order. I've just been prescribed more by them too.

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