Only way I can lose on Mounjaro is to eat no more than 500 cal and exercise

[PositiveEnergyyy]

Hello everyone
I have been on MJ for 2 1/2 months. I have very good loss in the first five weeks I lost about 1 stone. I carried on the second month and lost 4kg. Then everything came to a halt. 4 weeks of losing nothing.
I upped my dose to 3 mg and still had great appetite suppression. I have always eaten about 900 cal a day forcing myself. I dropped my calories to 800 and then 700 still lost nothing. The only way the scale started to move a little bit is by dropping my calories to 500-600. I am still doing 10,000 steps a day.
I still have about 3 stones to lose to get to healthy weight and I can’t carry on eating so little. Even though I am not hungry, It is not healthy.
I take v low thyroid meds dose but my TSH is fine now and T4 which is low is within rage so no way the doctor will up my dose. I don’t think I have a whoosh effect coming either. I also took 2 days re feed and ate at 1100-1200 cal a day and that did nothing.
Everyone here says to up the dose when the appetite suppression goes but I have good appetite suppression. No sure what to do.
Grateful to anyone for suggestions that works or anyone with similar experience and what they did to get losing again.

Maybe there, and she is going to speak to a Dr too, but look up metabolic adaptation, That's science, not nonsense.

It’s not possible to not lose weight if you’re consistently only eating 700 cals a day, even without exercise. You must either be underestimating how much you’re eating or have a medical problem. If you’re really eating that little every single day and not losing weight you need to go to your doctor to find out why

Metabolic adaptation only reduces caloric need by about 120 calories a day on average. If a woman’s TDEE is around 1700 that would mean they would still lose weight on 1400 even with metabolic adaptation. Otherwise how do you think anyone starves to death?

Adult women burn more than 1000 calories just by being alive even if they are small and slender.

How’s your body fueling itself then, if it’s not food or drinks and you’re not burning food or muscle, thus making your body lighter?

you need to speak to a doctor.

Absoltely and you still lose weight as expected. I wonder if these posters have never seen an anorexic or a famine victim,

I wonder if you have spoken to a medic or a scientist and fully understand. The poor lady is struggling with her weight loss and continues to reduce her eating. If she was losing weight on 1000 or 1200, why do you think she went down to 500-600? Possibly a medical issue, as suggested. You carry on thinking you know better than the medical experts Rosenbaum & Leibel (2010), Adaptive thermogenesis in humans: https://doi.org/10.1038/ijo.2010.184
Müller, Enderle & Bosy-Westphal (2016), Changes in Energy Expenditure with Weight Gain and Weight Loss: https://doi.org/10.1007/s13679-016-0237-4
Heymsfield et al. (2014), Weight loss composition is one-fourth fat-free mass: https://doi.org/10.1111/obr.12143
van Baak & Mariman (2023), Physiological factors affecting weight regain: https://doi.org/10.1038/s41574-023-00887-4.

The Heymsfield et al. (2014) one is the strongest, should you care to read any of them, but sorry, of course you know better.

There is no way OP’s metabolism slowed down so much within 2 months that she can maintain her weight at 500 calories per day. Adaptive thermogenesis is real but this is way too extreme.

I see three possible explanations:

• OP is eating more calories than she thinks
• OP’s body is retaining water, possibly due to the recent heatwave, menstrual cycle or a combination of both, while weight loss is happening in the background
• There is another medical issue

It could be a combination of all of the above. Solidarity, it must be disheartening.

She's only been doing this for a short time because she mistakenly thinks she's stopped losing weight after losing 2 stone in 3 months 🙄

Eating 500 calories a day is extremely dangerous. My daughter is recovering from an eating disorder and we were told that if patients were eating 500 calories a day or less, this was the point they were immediately hospitalised. You could be doing serious damage to your heart and other bodily functions.

Also trying 'different strategies over 4-5 weeks' isnt a great idea. It wont be enough time to see a difference and will just mess your system up.
Maybe its time to step back and give your body a break.
Try resetting your calorie deficit to no more then 100 calories and give it at least 4 weeks.
Remember you arent in a race and there is no rush to lose the weight.

Rosenbaum is discussing weight regain in this article, not weight maintenance on drastically reduced calories. The second is discussing where the body burns energy during weight loss, nothing to do with maintainig weight on calories below BMR, the third states that muscle is lost as well as fat during weight loss. The final one discusses psychology of weight regain.

None of that proves your point that people can eat 500 calories a day and stay the same weight. Did you even read any of them?

You have missed the point – yes, I read them.

Then your point hasn’t been made clearly… perhaps you should try and explain it again? Using your own words.

Read the abstract - from the paper Abstract - yes copied from the paper direct
The increasing prevalence of obesity and its comorbidities reflects the interaction of genes that favor the storage of excess energy as fat with an environment that provides ad libitum availability of energy-dense foods and encourages an increasingly sedentary lifestyle. Although weight reduction is difficult in and of itself, anyone who has ever lost weight will confirm that it is much harder to keep the weight off once it has been lost. - The over 80% recidivism rate to preweight loss levels of body fatness after otherwise successful weight loss is due to the coordinate actions of metabolic, behavioral, neuroendocrine and autonomic responses designed to maintain body energy stores (fat) at a central nervous system-defined 'ideal'. This 'adaptive thermogenesis' creates the ideal situation for weight regain and is operant in both lean and obese individuals attempting to sustain reduced body weights. Much of this opposition to sustained weight loss is mediated by the adipocyte-derived hormone 'leptin'. The multiple systems regulating energy stores and opposing the maintenance of a reduced body weight illustrate that body energy stores in general and obesity in particular are actively 'defended' by interlocking bioenergetic and neurobiological physiologies. Important inferences can be drawn for therapeutic strategies by recognizing obesity as a disease in which the human body actively opposes the 'cure' over long periods of time beyond the initial resolution of symptomatology.

And to point it out

The over 80% recidivism rate to preweight loss levels of body fatness after otherwise successful weight loss is due to the coordinate actions of metabolic, behavioral, neuroendocrine and autonomic responses designed to maintain body energy stores (fat) at a central nervous system-defined 'ideal'. This 'adaptive thermogenesis' creates the ideal situation for weight regain and is operant in both lean and obese individuals attempting to sustain reduced body weights. Much of this opposition to sustained weight loss is mediated by the adipocyte-derived hormone 'leptin'. The multiple systems regulating energy stores and opposing the maintenance of a reduced body weight illustrate that body energy stores in general and obesity in particular are actively 'defended' by interlocking bioenergetic and neurobiological physiologies.

Your body is just protecting itself, and this lady in question has been continuously reducing her calories to try and beat it. 500 - 600 means she will likely be liquefying her muscles. It isn't healthy.

I hope this is now easier to understand. Show the papers to doctors/medics and scientists and ask them if it’s not clear. They will know this anyway - they don't need to read a published paper. On average, women need a basic amount of calories for their bodies to function; forget aesthetics. Think heart pumping, organs working, etc; if we don't eat enough for our basic metabolic system, it will turn to our muscles. That's science, not a point of view. This lady is trying to beat it but is damaging herself. People think 'scales' - it is wrong; it is adipose/fat that we should be trying to lose, not weight. Think body composition.

It isn't easy to put muscle on so hang on to everything you've got. Abstracts are all you need to read in a clinical paper unless you want lots of specifics.