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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

WLIs to stop food noise? Any advice?

33 replies

WLIcurious · 21/06/2026 10:36

I eat healthily and exercise but menopause and a bad winter means I seem to be in a rut of snacking and emotional eating and I am putting on weight which needs to stop before it gets out of hand, so I am thinking of trying a low dose of WLI just to stop the food noise. Without the snacking my diet is fine and I can maintain a healthy weight.

Mounjaro looks like the best option but where do I start with dosing? Should I start on 2.5mg and then go down, or start on a smaller dose and go up if needed. I just want enough to stop the noise.

OP posts:
Itscoldouthere · 24/06/2026 15:57

I’m interested to see if people in maintenance switch to the pills and try reducing the dose, like taking every other day instead of every day, I’m sure it will be a while before anyone talks about it, but I’m imagine lots are thinking it’s a possibility.
I’m 2 year of taking MJ, I’ve been maintaining now since last October, I did drop down to 2.5 but went back up to 5 over winter, about to try 2.5 again, however when I started this journey I had no idea I would take it for so long, now I can’t imagine stopping, so the pills are something I might consider if I could spread them out to make them more cost effective, the long term cost of the injection is not something I initially considered.

SilenceInside · 24/06/2026 15:57

It's really not like taking a "lick" of nurofen. If you look at the trial data, eg SURMOUNT-4, every participant started on 2.5mg of Mounjaro. The average weight lost in the first 4 weeks, on the 2.5mg dose, was about 4% of starting weight. Because the half life of tirzepatide is 7 days, the amount in your system builds each week, so once you have done your 4th injection you have around 3.5mg of medication in your system at the highest point.

5mg was the lowest dose of Mounjaro that was studied long term, but that doesn't mean that no one will lose any weight on the 2.5mg dose, or only a very rare few. It just means that it's less than half of people, and that 5mg is the first dose level where most people will lose a clinically significant amount of weight.

MoneyJo · 24/06/2026 16:35

I can't imagine many will switch to the pills. From what I've seen so far in emails from pharmacies the pills aren't really cheaper plus they sound like a right faff.

TomClarkson · 24/06/2026 16:36

Cloudconfusion · 24/06/2026 15:45

Yes you’d need to chop it up,

I genuinely think try the drugs, the poster who lost eight stone, by taking 0.25, a twentieth of the lowest therapeutic dose will be very unusual. I’d really not assume you can do the same. It’s like taking a lick of a nurofen.

Nobody on the thread has claimed to do that

SexyFrenchDepression · 24/06/2026 18:28

Cloudconfusion · 21/06/2026 15:37

5mt is the first therapeutic dose , 2.5 is a half dose to get your body used to it; some will experience placebo effect and it will work lower, but it’s like taking a quarter of a nurofen when the dose is 2.

Are you getting your fractions muddled?

2.5mg is half of 5mg, quarter of a nurofen is 1/8 of 2. I dont really understand what you're saying

Anyway, I started on 2.5mg as recommended and lost 4 stone, I went up to 3.75mg for a few weeks but didnt need to so went back down. Its definitely not a placebo effect, there are many who it works for. It has never been said people dont lose on it, just that recommended full dose is 5mg and some may need to go higher. It also has no bearing on how much you weigh either, some heavier people may be fine on 2.5mg but some who are lower BMIs need to go up the doses more.

gotmyselfintoapickle · 25/06/2026 08:02

Cloudconfusion · 21/06/2026 15:37

5mt is the first therapeutic dose , 2.5 is a half dose to get your body used to it; some will experience placebo effect and it will work lower, but it’s like taking a quarter of a nurofen when the dose is 2.

The term ‘therapeutic dose’ is a population-level concept, it’s derived from clinical trials and represents the dose that works for most people, but individual variation can be significant.

Some people never progress off 2.5mgs and lose a lot of weight. It’s not a placebo. The response doesn’t ’turn on’ at 5mgs, it’s a distribution with the majority of people not responding on doses less than 5mgs.

MoneyJo · 25/06/2026 08:38

Well explained @gotmyselfintoapickle I had amazing results for the first few weeks on 2.5mgs.

LoveYouPickle · 25/06/2026 08:51

I found 7.5mg the food noise went completely but my mojo upped and went as well! I had nary a thought in my head 😂😂

I was like my golden retriever! I want to come off now I have lost weight which is good but it's definitely taken something away from me. It's easing a bit now I've gone lower. Just saying that no food noise for me - no noise at all!

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