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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Has anyone stayed on a lower dose of weight loss injections long term and still lost a lot?

44 replies

MoneyJo · 20/05/2026 13:05

I did a month on 2.5, a week on 3.75 and tomorrow will be my 6th dose of 5. I am still having decent suppression and little food noise so I am hoping to keep the price down and stay on 5mgs long term.
Has anyone else been able to stay on a lower dose long term without having to go up the doses? Just wondering if I am deluding myself and will have to go up as time passes.

I've lost 1 and a half stone since starting at the beginning of March but have another 5 and a half stone I would like to lose.

OP posts:
JabbaJibba · 20/05/2026 18:52

I've lost 7 stone in 14 months, 9 months on 2.5, faffed about for 3 months with 3, 3.5, 3.75 and stalled. Moved to 5 in February and started losing again. Don't plan on going any higher. Another 1.5 stone to go.

gwrbakes · 20/05/2026 19:03

MoneyJo · 20/05/2026 15:41

So many interesting responses thank you.
I'm optimistic that I might be able to just stay on 5 for a long time. If I can keep losing 2lb ish a week I would be happy with that.

My losses were quite good in the first 6 or so months then they slowed and the last 6 months I have only lost a stone so very slow now. I’m happy with my weight now but I still need another stone off to hit that ‘healthy’ zone. I’m in no rush now and if it takes another 6 months or even a year that’s ok, after losing 9 stone I already feel so ‘normal’!

MoneyJo · 20/05/2026 22:38

gwrbakes · 20/05/2026 19:03

My losses were quite good in the first 6 or so months then they slowed and the last 6 months I have only lost a stone so very slow now. I’m happy with my weight now but I still need another stone off to hit that ‘healthy’ zone. I’m in no rush now and if it takes another 6 months or even a year that’s ok, after losing 9 stone I already feel so ‘normal’!

Good going!

OP posts:
Boymum2104 · 21/05/2026 07:07

I lost 4st on 2.5 & then another 1st on 5, took me 6 months

MoneyJo · 21/05/2026 07:51

Wow that's a pretty quick loss @Boymum2104 well done!

OP posts:
Youthinkyourefunny · 21/05/2026 10:42

No. I had to go by the book. Had been a serial dieter which inevitably led to insulin resistance. So 4 weeks 2.5mg, 4 weeks 5mg and so on up to 15mg where I stayed for 5 months before titration down. Lost 8 stone in 11 months. 20 st to 9 st. Have maintained of 5 mg for 15 months and do not move the scales more than a kg up or down .

WeAllHaveWings · 21/05/2026 12:47

After decades of yoyo dieting I lost 9st 10lbs over 18 months on my highest dose of 3.75mg to reach a healthy BMI for the first time in 35+ years! Maintaining for 5 months now.

I'm not sure if I even had to increase to 3.75mg, but I did as back then I was told by my provider to increase so I thought I had to and wanted to do slowly.

I never had any major side effects, but I didn't increased for a few reasons -

  • I didn't like the intense initial suppression I had in the first couple of months, I was happy with the food noise reduction
  • I wanted to stay low due to cost of highest doses
  • I decided to stay on each dose until the end of each pen (6 weeks), during this I learnt that some days or even weeks the effects would be less but would kick back in the following week - at this point I decided I would stay on the same dose unless I consistently struggled to keep to my calorie deficit for at least 3-4 weeks
  • I started HRT around 6 months into my weight loss and increasing MJ dose would have meant contacting my GP to change my HRT dose (it would have affected my oral progesterone) - that also encouraged me not to increase unless needed

It is possible to, and many do, lose substantial weight on the lower doses but it is dependent on a few factors, some within our control (expectations, consistent and effective changes to diet, reducing stress, improving sleep, managing emotional eating, even hydration) and some outside (response to medication, hormonal factors, metabolic differences, other health conditions).

HappyWineDay · 22/05/2026 08:51

My OH has been on MJ for around a year. First 6 months on 2.5mg, then 6 months on 3.75mg and still losing. She’s gone from 13st to just under 10st and is just into the “healthy” BMI. That’s 23% of body weight.

Despite the patient leaflet advising to move up to 5mg after 4 weeks for a therapeutic dose, their own trials at 1.25mg showed it to be therapeutic versus placebo.

MoneyJo · 22/05/2026 09:07

Really interesting thanks.

I will aim to stay on 5mg but might get a 7.5 pen next to make it cheaper.

OP posts:
Carol243 · 28/05/2026 21:55

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Linda983 · 29/05/2026 16:21

I’m on Mounjaro and have stayed on 5mg as it’s still working for me😊 The food noise easing off has been the biggest change, I’ve just been doing more walking and cooking at home. I had a bit of nausea and constipation early on but it settled after a few weeks👍

MoneyJo · 29/05/2026 16:30

How long have you been on 5 @Linda983 ?

OP posts:
IwanttoWFH · 29/05/2026 17:31

I lost 3st 3lbs. I spent 5 weeks on 2.5mg, 9 weeks on 5mg and then stayed on 7.5mg for 22 weeks until I reached my target weight. I then dropped back down to 5mg (as I was still losing weight on 7.5mg) and have been maintaining on this for 13
months. It’s definitely possible. I think some people move up way too fast. It’s better to stay as low as possible for reasons such as learning new habits, cost and being able to maintain effectively.

KrazyKatty · 30/05/2026 11:58

I’m on 3.5mg and losing slowly at about half to a 1lb a week now. I’ve lost 4 stones over about 10 months and need to lose at least one more stone to be about 25bmi, but I’m happy where I am and prefer to lose the last bit slowly as my skin is quite loose and wrinkly looking in places.

I’m also worried about losing bone density as I’m 60yrs old and my GP said that it was a genuine cause for concern in older people losing weight too quickly. ☹️

Binus · 31/05/2026 10:54

I never went above 5 and lost about 20% of body weight, albeit I'm short and was low 30s so it wasn't much more than a couple of stone. It was always slow and steady for me, which I felt comfortable with, and I bridged at a 3.75 dose for about 2 months before going up to 5. Maintaining at 2.5 now.

From what I've read, it's the luck of the draw how you respond to the lower doses.

Carol243 · 02/06/2026 21:45

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Clemdfandango · 02/06/2026 22:30

I stayed on 2.5 for one pen but although I lost 3lb per week, I really struggled because there was no appetite suppression or blocking of food noise, so I feel I really did it on my own, which I knew I would never maintain, so I went up to 5mg and now the appetite suppression is strong and food noise is zero.

I've lost 2st 6lb since the end of February amd still have around 5.5 stone to go.

I'm hoping to stay on 5mg until I reach my target weight, fingers crossed.

soundsys · 02/06/2026 23:58

3 months on 2.5 here and have lost 10kg

SweetChilliGirl · 18/06/2026 16:56

I've lost 4 stone - I'm now 8 stone 6 pounds - over a year and have maintained for about three months now. The highest I went up to was 4mg - for about 2 months and I'm now down to 1.5mg. I plan to get down to 1mg in a few months and then 0.5mg, where I will stay indefinitely, going back up to 1mg if I need to. MJ has helped with my menopausal sore hips and feet too and I don't want to be in pain again.

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