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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Nervous to start weight loss injections and worried about side effects

56 replies

Ismo456 · 17/05/2026 20:50

It’s been sitting in my fridge for a week and I can’t pluck up the courage to take the first jab!

im so depressed about my weight and shape - 3 babies and I seem to have accumulated weight from each and if I was more disciplined and had a better relationship with food and more time to myself to exercise I would probably be able to shift it. But I’m just stuck in a rut of not caring how much I eat anymore because I’m overweight anyway.

I would be happy to lose 1.5 stone, and over the moon to lose 2. That’s all I need!

I know this is something I need to do for myself, I don’t want to have to dread another summer and spend it trying to cover myself up. But I just can’t find the courage to start!

terrified of the side effects, and feel selfish if I make myself ill by doing this and end up struggling to look after the kids?

I know this sounds extreme, but I have pretty bad health anxiety as it is and I just worry so much about getting bad side effects.

can anyone help me out some positive pants on and get this done!

OP posts:
SilenceInside · 17/05/2026 20:54

Maybe it’s easier if you have a lot of weight to lose, it makes the decision process a lot easier as the benefits massively outweigh the risks.

At the moment, staying obese or overweight is going to be bad for your health long term. Losing weight will overall reduce your risk of various long term health issues. Does it help to think of it like that?

Are you getting any treatment for your anxiety?

MeridaBrave · 17/05/2026 20:55

if you really are worried take a half dose the first week will result risk of side effects, just wind the pen 30 clicks instead of 60. But I never had any side effects and I lost 2 stone in 3 months.

Ismo456 · 17/05/2026 21:17

SilenceInside · 17/05/2026 20:54

Maybe it’s easier if you have a lot of weight to lose, it makes the decision process a lot easier as the benefits massively outweigh the risks.

At the moment, staying obese or overweight is going to be bad for your health long term. Losing weight will overall reduce your risk of various long term health issues. Does it help to think of it like that?

Are you getting any treatment for your anxiety?

Yes I think it’s probably the fact that I know if I actually had some willpower, and some time, and didn’t keep making excuses for my bad habits, I would be able to lose it myself. Maybe it’s almost that I feel guilty to give myself something to make it easier for me?

also I just keep panicking that I’m going to jab and end up stuck on the toilet or throwing up for days, an with 3 little ones I just don’t have the time to do something that might make me ill!

OP posts:
Ismo456 · 17/05/2026 21:19

MeridaBrave · 17/05/2026 20:55

if you really are worried take a half dose the first week will result risk of side effects, just wind the pen 30 clicks instead of 60. But I never had any side effects and I lost 2 stone in 3 months.

Yes I did think about doing a smaller dose, would it still be possible to lose weight like that?

wow that’s amazing in 3 months, especially with no side effects! Well done to you x

OP posts:
Laarah · 17/05/2026 21:23

This was me. Mine sat in the fridge for nearly 3 months before I could psych myself up to take it. Now I’m the weight I was ten years ago and I’m so pleased I started. I’m about to go back down to 2.5mg though since 5mg makes me permanently nauseous. 2.5mg works well though. I have no appetite at all.

SilenceInside · 17/05/2026 21:29

@Ismo456 you’d be extremely unlucky to have such severe side effects immediately. And I think most of us who take WLI have family, work commitments and so on that we don’t have time to be ill for. Most people don’t get side effects and if you do get them they are usually mild and manageable.

Presumably when you filled out the consultation you were thinking about improving your health and wellbeing when you applied to get Wegovy/Mounjaro? All the things that made you apply still exist now, they won’t change unless you make a change.

If you start with a half dose, you might not get the full effects or any effects. You might not get the full effects until you get to a higher dose anyway, many people need the higher doses to lose weight effectively. The reason to do a half dose is to be sure you aren’t going to get any side effects, and weight loss would be less important. You’d just be taking the process a lot slower. Which if it helps you start then why not.

Kaynine · 17/05/2026 21:54

Just take the jab ,it really is such a non event,you might get side effects,a bit of nausea, indigestion,I puked once,but mainly I lost 2 stone in 2 months,stop dithering,and stop reading stupid overblown things in the press or social media, even the folks I know on the dodgy jabs haven't had any problems,just weight loss, quickly and easily.

madeinthe80z · 17/05/2026 22:30

I was the same as you and honestly it’s been fine and having read A LOT of threads on here that seems everybody else’s experience too.

To protect myself somewhat I did a few things that maybe helped reduce likelihood of symptoms but mainly just made me feel better.

I ate ‘clean’ for 48 hours prior. I avoided anything greasy, fatty, sugary etc and I didn’t overeat. I just made sure that once the drug went in my tummy hadn’t been overloaded prior. Also drank loads of water as is the advice when you are on MJ

I jabbed about 9pm at night so that I could sleep through symptoms.

I had plenty of rennie to hand and honestly this is all I have needed. I woke up at 3am after my first jab with a slight stomach ache and a bit of nausea. I sucked a rennie and 10 mins later, I was fine and rolling over back to sleep. Literally that’s the only proper discomfort I had.

I did a day where I was WFH the next day and my husband was around also to help with kids if needed but I didn’t need to worry. I was tired but then I always am so 🤣

Take the plunge. I’m so happy I did. Good luck x

Ismo456 · 17/05/2026 22:34

Kaynine · 17/05/2026 21:54

Just take the jab ,it really is such a non event,you might get side effects,a bit of nausea, indigestion,I puked once,but mainly I lost 2 stone in 2 months,stop dithering,and stop reading stupid overblown things in the press or social media, even the folks I know on the dodgy jabs haven't had any problems,just weight loss, quickly and easily.

This is exactly what I needed to read - thank you!!

I’ll re read this as I jab tomorrow 😂

OP posts:
Ismo456 · 17/05/2026 22:35

madeinthe80z · 17/05/2026 22:30

I was the same as you and honestly it’s been fine and having read A LOT of threads on here that seems everybody else’s experience too.

To protect myself somewhat I did a few things that maybe helped reduce likelihood of symptoms but mainly just made me feel better.

I ate ‘clean’ for 48 hours prior. I avoided anything greasy, fatty, sugary etc and I didn’t overeat. I just made sure that once the drug went in my tummy hadn’t been overloaded prior. Also drank loads of water as is the advice when you are on MJ

I jabbed about 9pm at night so that I could sleep through symptoms.

I had plenty of rennie to hand and honestly this is all I have needed. I woke up at 3am after my first jab with a slight stomach ache and a bit of nausea. I sucked a rennie and 10 mins later, I was fine and rolling over back to sleep. Literally that’s the only proper discomfort I had.

I did a day where I was WFH the next day and my husband was around also to help with kids if needed but I didn’t need to worry. I was tired but then I always am so 🤣

Take the plunge. I’m so happy I did. Good luck x

I really needed to read this thank you!!

im going to just get it done with tomorrow, and I suppose even if it doesn’t agree with me, it will only be a week at worst!

OP posts:
ButterYellowFlowers · 17/05/2026 22:40

Would you rather feel a bit sick sometimes or continue to remain the same weight and feel depressed? It’s no different from any other medication all of which come with risks of side effects.

The side effects I had? My IBS went away, my bloating went away, my brain became clearer, my focus sharpened and my eczema calmed down.

I lost almost 3st in 6months.

Obesity increases your risk factor for developing almost every major non-communicable disease from cardiovascular disease to diabetes and cancer.

Greenfingers37 · 17/05/2026 23:11

I was really worried about side effects too but I’ve had none! Maybe a tiny bit of heartburn but nothing a Rennie won’t sort and feeling a bit more tired than normal but that’s it! Nothing that has stopped me going to work or about my daily business.
I started last week and can’t believe the impact it’s had on my appetite. Do it- you won’t regret it.

rebus · 18/05/2026 03:55

I'm glad you've resolved to start tomorrow! As a previous poster mentioned, you can give yourself a halfdose the first week, or even 3/4 dose to balance effectiveness with concern wrt side effects.

Will mention that the initial starter doses are purposefully set very low (usually 2.125-2.5mg) to get your body used to the medication and minimize side effects.

The side effects were quite manageable for me, and since I lost 2 stone in 3 months, I thought it was completely worth it.

Wishing you an easy first week!!!

ThatMerryFox · 18/05/2026 08:34

I had mine in the fridge for 2-3 weeks. I did have mild side effects (nausea, cramps) on 2.5, so did 30 clicks for few weeks and have been increasing slowly. I'm currently on 1.75 (42 clicks) I've lost 1 stone in 9 weeks, which is great and I'm feeling good. There's no rush and I'm happy to be improving my health by preventing the issues caused by obesity. Go for it, you'll be fine x

letsgooooo · 18/05/2026 11:47

I had no side effects at all on 2.5mgs until I had a couple of glasses of wine then I felt really sick so be careful with the alcohol.

I am not obese and have always been able to lose weight pretty effectively but since having kids and basically being tired for years, I have just struggled to find the enthusiasm to bother to lose weight. I took my first dose last week and it's been great so far. Very easy to eat less and eat more healthily. I think i'll only be in it for a couple of months but it's been the kick I have needed.

JHound · 18/05/2026 12:00

I had almost no side effects till I got to 7.5mg (first dose on Friday.)

I had very very very slight sensation of being bloated a couple days after injection day for 2.5mg and 5mg. But my first dose of 7.5mg I have spent all morning with diarrhoea. And I am in the office so very difficult to manage! 😆

Ismo456 · 18/05/2026 14:39

Thanks so much everyone. You’ve helped give me the push I needed to get it done. Today will be the day!!

OP posts:
madeinthe80z · 18/05/2026 19:13

@Ismo456 have you done it?! Let us know if you need a cheer!

PearlsTeapot · 18/05/2026 19:19

Did you go for it? My only regret was not starting sooner!

Do it just before bed and you'll sleep through the anxiety of side effects. I have none except constipation.

Ismo456 · 18/05/2026 19:48

I did it after lunch!! So proud of myself!

nothing worth reporting so far, a little light headed feeling and tired, but neither is hugely unusual for me.

hoping tomorrow is ok!

OP posts:
madeinthe80z · 18/05/2026 19:51

Well done! 👏 fingers crossed all goes super smoothly for you!

Greenfingers37 · 18/05/2026 20:07

Bravo!!! 🙌

Ismo456 · 18/05/2026 20:18

Hoping tonight/tomorrow isn’t too eventful - but half the anxiety has already gone just from actually going through with starting it!

OP posts:
Kaynine · 18/05/2026 20:21

@Ismo456 yay, you'll be fine, here's to the easiest weight loss you'll ever do 🍾

Greenfingers37 · 18/05/2026 20:22

Ismo456 · 18/05/2026 20:18

Hoping tonight/tomorrow isn’t too eventful - but half the anxiety has already gone just from actually going through with starting it!

You honestly won’t look back.

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