Help end medical misogyny. Sign our petition.

Help end medical misogyny.
Sign our petition.

Sign the petition

Please or to access all these features

Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Has anyone had better results switching from Wegovy to Mounjaro?

2 replies

Hopthegoodgod · 22/04/2026 20:58

Only lost 2 stone on wegovy after max dose for over 2 yrs. Switched to mounjaro 8 weeks but no effect as yet. Am i really a non responder? Anyone successfully switched from W to Mj? Bit disillusioned tbh. Moderately active and bmi currently 25 ish.

OP posts:
Kitt1 · 15/05/2026 18:59

If your bmi is 25 after losing only 2 stones then presumably you weren’t clinically obese to start with?

Apologies if I’ve got this wrong but I’m guessing that you don’t have any other medical issues associated with clinical obesity and maybe that’s why they’re not working for you?

Gardengargoyle · 15/05/2026 19:08

Reading these threads it is easy to get the impression that most people manage to remain on the lowest doses and lose loads of weight very quickly. Some people are very sensitive to the injections and never need to increase the dose above the starting dose of 2.5 or the lowest therapeutic dose of 5mg/mL.

You're obviously not one of the super responders since you were able to take the highest dose of semaglutide for 2 years without turning into a walking skeleton.

You did manage to lose two stones in that time, so you aren't non-responsive either. You are probably just like the majority of people in the drug trials, who need to go up through the doses and remain on the highest dose to get results.

After 2 months on Mounjaro it's too early to know if you will respond or not. I think if you tend towards morbid obesity you should be prepared to go up to 15mg and stay on it for however long it takes to reach your goal weight, after which you can then gradually reduce to a lower maintenance dose.

I've been losing weight for 4 years and 2 months now. I'm 68 and I've lost massive amounts of weight at different stages of life, but always regained it all with a bit more on top.

At 160kg (25 stone) I'd completely given up, my BMI was 62.5 and my diabetes was uncontrolled and heading towards inevitable (if something else didn't kill me first) blindness and foot amputation.

Today, after 50 months of patient plodding I'm down to BMI 25.5. I know that without the medication I would have fallen off the wagon long ago, probably after the usual 5-6 months of tooth gritting, fist clenching determination and misery in light of previous experience. A few months of no loss and I'd just despair and start eating until the constantly gnawing hunger pains were silenced.

The magic of GLP-1 drugs is that they make it possible to just keep plodding along. Even when you don't lose any weight you're not regaining the weight you lost before, and sooner or later, if you track what you eat and stay within sensible calorie limits your body will adjust to the new weight and you'll lose a few more kilos.

I think it's different for people who have never suffered from morbid obesity. Some of them might be able to use GLP-1s as a quick fix, then go cold turkey once they reach their weight goals. For the rest of us it's a drug for life.

New posts on this thread. Refresh page
Swipe left for the next trending thread