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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Are perimenopause symptoms being wrongly attributed to Mounjaro and weight loss jabs?

19 replies

JasmineIndigo · 19/04/2026 08:58

This is one of the most bizarre things I’ve seen Mounjaro take the blame for - the mid 40s women quoted in this article are talking about classic perimenopause symptoms and blaming the jabs. Quite odd!
https://www.dailymail.co.uk/health/article-15744861/lost-stones-Mounjaro-problem-women-weight-loss-jabs-shocking-effect.html

We lost stones on Mounjaro, but gained this life-changing problem

Research has suggested that, in addition to changes in digestion, GLP-1 drugs may influence brain pathways. One weight-loss jab user said: 'I feel like Mounjaro has stolen one of my pleasures in life.'

https://www.dailymail.co.uk/health/article-15744861/lost-stones-Mounjaro-problem-women-weight-loss-jabs-shocking-effect.html

OP posts:
SilenceInside · 19/04/2026 09:26

Presumably people get paid to be the subject of these DM pouty sad face stories?

GiveMeWordGames · 19/04/2026 09:53

I refuse to give the Daily Heil my clicks but yeah, it's predictably pathetic. The press would blame WLIs for, I dunno, climate change if they could.

Teaandwater · 19/04/2026 09:55

I read that this morning and thought the same. Bizarre.

aodirjjd · 19/04/2026 09:55

Behind a paywall?

JasmineIndigo · 19/04/2026 10:00

aodirjjd · 19/04/2026 09:55

Behind a paywall?

Oh sorry didn't realise that - basically it is an article with mid to late 40s women saying that they are teary when drinking alcohol and picking fights with their husbands plus having less tolerance to alcohol since taking the WLI. But surely the thing making it hard for them to lose weight in their 40s hence them going on Mounjaro is exactly the same thing making them teary and emotional aka perimenopause!

OP posts:
WeAllHaveWings · 19/04/2026 10:04

I don’t pay for Daily Mail as their articles are shit, so I can’t read the story.

Weight loss can cause hormone changes, I was 2 years post menopause, my weight loss triggered awful menopause symptoms and I needed to start HRT. But it is not a direct result of the injections, it is the weight loss (fat stores estrogen, less fat less estrogen)

VoyOySaveloy · 19/04/2026 10:10

I can't read the article as it's behind a a pay wall, but as someone post menopausal who experienced dreadful panic attacks and anxiety on MJ I do object to women suffering new symptoms on any medication having it ascribed to perimenopause/menopause/hormones and therefore dismissed.

LadyOfACertainAge · 19/04/2026 10:17

The thing is that it could be either (or just related to losing weight irrespective of how you did it). For example, thinning hair!

Mine was the other way round… I was getting terrible weird dreams and not sleeping very well at all and was putting it down to perimenopause. It was only after a few weeks I spotted a pattern of it being worse on jab nights. So I reduced my dose back dow and it’s been fine.

GladFatball · 19/04/2026 11:04

I read it earlier, by copying and pasting the link into archive.ph.

My first thought was perimenopause. I'm there right now. I've been on MJ for a year and a half and it's only lately that my tolerance for alcohol has plummeted. I ascribed it to 1) my age and 2) the fact that I'm 8 stone down.

I mean, MJ definitely reduces the desire to get drunk for me, and has from the start. But I don't necessarily mourn that. Almost certainly healthy for me.

One of the women in the article saud she was questioning if the weight loss was worth it now that she can't drink, an attitude which I can't relate to at all.

JasmineIndigo · 19/04/2026 11:11

VoyOySaveloy · 19/04/2026 10:10

I can't read the article as it's behind a a pay wall, but as someone post menopausal who experienced dreadful panic attacks and anxiety on MJ I do object to women suffering new symptoms on any medication having it ascribed to perimenopause/menopause/hormones and therefore dismissed.

I agree that attributing anything health related in older woman to the menopause/perimenopause without really looking into it is awful, but I’m only referring to this particular article and the women in it blaming mounjaro for what are classic perimenopause symptoms without questioning whether this might be the cause of their emotionally volatile states, or at least a contributor.
(And apologies all I didn’t realise this was behind a pay wall, I’m on my MIL’s iPad today)

OP posts:
JasmineIndigo · 19/04/2026 11:11

VoyOySaveloy · 19/04/2026 10:10

I can't read the article as it's behind a a pay wall, but as someone post menopausal who experienced dreadful panic attacks and anxiety on MJ I do object to women suffering new symptoms on any medication having it ascribed to perimenopause/menopause/hormones and therefore dismissed.

(Duplicate post)

OP posts:
JasmineIndigo · 19/04/2026 11:11

VoyOySaveloy · 19/04/2026 10:10

I can't read the article as it's behind a a pay wall, but as someone post menopausal who experienced dreadful panic attacks and anxiety on MJ I do object to women suffering new symptoms on any medication having it ascribed to perimenopause/menopause/hormones and therefore dismissed.

(Triplicate post!)

OP posts:
QueefQueen80s · 19/04/2026 11:16

I think people put far too many things down to peri actually, when actually a lot of the time it’s poor lifestyle choices and bad marriages etc

JasmineIndigo · 19/04/2026 11:31

QueefQueen80s · 19/04/2026 11:16

I think people put far too many things down to peri actually, when actually a lot of the time it’s poor lifestyle choices and bad marriages etc

Yes but the perimenopause often shines a light on those bad marriages when oestrogen drops and women no longer have the capacity to put up with them anymore - still nothing to do with mounjaro!

OP posts:
DanaScullysLegoHair · 19/04/2026 11:39

Hmm, interesting. I'm 46, firmly in peri and can say with confidence that since starting WLI (Wegovy) yes, my desire for alcohol has dropped BUT I have seen a vast improvement in my overall wellbeing. I don't feel as anxious, no constant whirring thoughts and no more uncomfortable 'hot' and bothered episodes.

It isn't weight loss making me feel better as I've only lost 40% of what I'd like to, you can't see any big changes yet but WLI has coincided with the positive changes.

Might be a coincidence, might not. I think not. It feels like a wonder drug to me.

QueefQueen80s · 19/04/2026 12:58

JasmineIndigo · 19/04/2026 11:31

Yes but the perimenopause often shines a light on those bad marriages when oestrogen drops and women no longer have the capacity to put up with them anymore - still nothing to do with mounjaro!

Edited

I agree it’s nothing to do with MJ and actually mj improves everything overall, I just don’t think everything is peri either.

Velvetandleather · 19/04/2026 13:32

I Read that article and rolled my eyes, I don’t know what’s going on in the mail but it is endless articles, mainly negative shite, about weight loss injections.

i guess it gets the clicks. So they keep doing it. But this is one of the more bizzare ones.

i guess we know there are a lot of jealous resentful people out there over these jabs, so maybe irs feeding into that, who knows.

but, “I get cunty with my husband after one glass of wine” is a whole new low in terms of embarassingly bad articles. Even for the fail.😂

Periperi2025 · 19/04/2026 13:40

WeAllHaveWings · 19/04/2026 10:04

I don’t pay for Daily Mail as their articles are shit, so I can’t read the story.

Weight loss can cause hormone changes, I was 2 years post menopause, my weight loss triggered awful menopause symptoms and I needed to start HRT. But it is not a direct result of the injections, it is the weight loss (fat stores estrogen, less fat less estrogen)

But even then it's not that straightforward.

At 16.5 stone i needed 200mcg Oestrogen (GP prescribing limit is 100mcg) and 13.5mg testosterone (normal prescription for women is 5mg) to achieve even mediocre levels of oestrogen and testosterone still wasn't really budging with that much.
With mounjaro and weight loss (4.5 stone so far) by Oestrogen shot up and i don't know what my latest testosterone was at it got sent down to Cardiff for second testing as it flagged up way to high (and I'd already reduced to 8mg by that blood test).

Endocrinology and metabolic health is a complex beast and there are still many questions to be answered regarding the effects of mounjaro.

VoyOySaveloy · 19/04/2026 14:33

QueefQueen80s · 19/04/2026 12:58

I agree it’s nothing to do with MJ and actually mj improves everything overall, I just don’t think everything is peri either.

The evidence suggests that for some people mood and anxiety improves and for others - albeit a smaller group - it triggers anxiety and other side effects.

How odd though that not everyone responds exactly the same way to a medication and that people have different side effects. That has never happened before in medical history 🙄

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