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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

HRT and WLI - how are you now taking your progesterone?

16 replies

GlomOfNit · 07/04/2026 11:41

I've been dithering, on and off, about WLI for well over a year now. I've not weighed myself in months (I can't get the hang of my new scales, they're 'smart' and clearly I'm not Grin but I really need to get to grips with them) but I was almost 11 stone (and I'm only just over 5') when I last weighed in and I can absolutely feel that I'm quite a bit heavier than that now. I have newer rolls of fat on my torso and back, my hips are massive, my knees and thighs feel like they're overlapping when I stand with legs together, I can see in my face that I've continued gaining, etc. I'm also finding it really hard/impossible to chase after my prone-to-bolting autistic son, which is a safeguarding nightmare, and worryingly I've started dreading stairs. Obviously I'll weigh in before making a final decision because I need to record BMI but I'm fairly sure I've now hit 30.

I feel that my main meals are already really healthy. I consciously try to keep the carbs (white carbs at least) to a minimum, I eat plenty of legumes and vegetables, I try to include as many different fruits and veg plants in a week as I can. I drink water as well as (a lot) of teas and coffee, I don't often drink alcohol. But the snacking is where it's creeping in. I make choices that a few years ago I would never have done, and that's incremental, so what was considered a 'treat' a few months ago is now more routine. I just can't turn the 'oooh you should have one of those' voice off. Some of my snacks are 'healthy' like fruit, nuts, cheese - but it's still extra snacking. So I think I'm conning myself into believing my diet is good, when all the things I eat in between really aren't helping.

I know I'm at a relatively low BMI/weight to start but I assume that if my BMI is indeed 30+ I'll be able to get it privately.

The main thing I'm worrying about (aside from side effects, loss of energy, hair loss, sticking a needle in myself...) is using it alongside HRT. I'm 52 and have been taking HRT since 2022. I recently changed the progesterone to continuous, so I take the same amount but spread out daily rather than over two weeks. But in any case, I know that HCPs are concerned that intake of oral progesterone can be compromised by WLI. I'm assuming this is because the WLI slow digestion (or change your metabolism??). Or is it a different issue? About a year ago I got a standard text from my GP surgery, clearly sent out to all women on HRT, saying that if I'd started taking WLI I needed to make an urgent GP appointment because there was a risk my progesterone wouldn't be absorbed.

What can I do about this? I know there's an off-license use of oral progesterone where you take it vaginally, but I've only just started continuous progesterone and I'm still bleeding most days and worried that might interfere with taking progesterone that way. I'm also a rule-follower and would want to run that past my GP first. What are others on HRT doing? Mirena? (I've been offered one in the past but have a history of cervical shock so very reluctant, but I'm now reconsidering that option.)

I just want to be able to exercise without dropping out almost instantly, reduce the arthritic ache in knees and feet, chase my bloody errant son, and fit back into my size 14 dresses (which is a pretty modest aspiration given some of the dramatic size changes I've read about on here!). I don't want to fit into size 10s, I'd be deliriously happy to be 9 stone again!

OP posts:
putthehamsterbackinitscage · 07/04/2026 13:19

My gp doubled my progesterone prescription- you need double for the initial 4 weeks or for 4 weeks when increasing dose.

i also have experimented with taking it vaginally and find that that also helps with dryness etc rather than using vaginal estrogen cream as frequently - the drawback is it doesn’t have the same sleep inducing effect as orally.

GlomOfNit · 07/04/2026 13:26

putthehamsterbackinitscage · 07/04/2026 13:19

My gp doubled my progesterone prescription- you need double for the initial 4 weeks or for 4 weeks when increasing dose.

i also have experimented with taking it vaginally and find that that also helps with dryness etc rather than using vaginal estrogen cream as frequently - the drawback is it doesn’t have the same sleep inducing effect as orally.

Ah ok, that's interesting. I wonder if any side effects from the progesterone would increase? I've found I coped fine with progesterone when I was taking it sequentially but since going continuous I'm really spotty! Hope it settles down.

OP posts:
ViolaPlains · 07/04/2026 13:34

I have continuous progesterone and it’s never been mentioned about WLI use by my GP or WLI provider.

raffles25 · 07/04/2026 13:41

I had gel and tablets, but now switched to patches due to wegovy

OneThirdLess · 07/04/2026 15:40

I am taking 2 capsules of Utrogestan 2 weeks on/2 weeks off which as the 'usual' prescription. I've not just started nor am I going up the doses of mounjaro, which is the usual contraindication. I'm maintaining. I've had no issue. Judging by my body's reaction to the progesterone, it's being absorbed fine. Which is a relief, as mirena isn't an option for me.

WeAllHaveWings · 07/04/2026 16:01

https://thebms.org.uk/wp-content/uploads/2025/05/23-BMS-TfC-Use-of-incretin-based-therapies-APRIL2025-E.pdf

https://www.pcwhs.co.uk/_userfiles/pages/files/resources/glp1_contraception_hrt_article.pdf

I started HRT including oral progesterone after I start Mounjaro. As my Mounjaro dose has not increased (in last 20 months) I haven't needed to do anything so have continued on oral progesterone. I have agreed with GP if I do intend to increase Mounjaro dose I should contact them to double up my progesterone for 4 weeks as I prefer to keep to micronised progesterone.

GoldieLookingBoots · 08/04/2026 14:13

I’m on 7.5mg of Mounjaro and have been using mj for 10 months. About 6 months ago my gp switched me from Evorel 50 patches with sequential progesterone tablets because new guidance came out from BMS. I’ve been struggling g with perimeno symptoms since then as I was put on Evorel sequi patches. After a review last week I’ve been given Lensetto spray to use daily and back on Utogestan. However, we are still in discussion about how to take the Utrogestan as I am 51 and still having periods. Gynaecologist advice is for a Mirena coil FFS! I had one more than 15 years ago for terrible periods. It did nothing positive for me. Why are they so adamant that women must have a bloody mirena coil? Anyway, I have another appointment with my GP possibly to discuss using Utrogestan vaginally. She said there’s less research around it but. Mj affects stomach absorption, so 🤷🏼‍♀️

Itscoldouthere · 08/04/2026 16:53

I just take it vaginally, just to be sure my MJ doesn’t effect anything, however I’m in maintenance and back down at 5mg so hope I won’t have to go up again.

susiedaisy1912 · 08/04/2026 16:57

I have the mirena coil and use estradiol gel as well. Been on MJ for two years now and feel much better overall

badboss2020 · 08/04/2026 17:00

Also Mirena and estrodial.

Clearingaspace · 08/04/2026 18:11

Lurking on this board as trying to decide about WLI

when my GP prescribed my progesterone she repeatedly told me I could take it vaginally almost like that was the preferable way to take it! I was pretty confused as there was no mention of this on the leaflet, but now you have said it’s off label use that makes sense. I guess if I do go for WLI I will finally try that method!

mrsconradfisher · 08/04/2026 20:37

I take the progesterone vaginally. I read it had far fewer side effects so been doing it that way ever since I started on it.
Just following this thread as I’m also debating whether or not to start WLI. I’m only 4 ft 11 and weigh about 80kg. It’s really getting me down now. I actually eat really small amounts of food anyway, it just seems every single thing I eat makes me fatter. Genuinely if I was a foot taller it wouldn’t be an issue!!

putthehamsterbackinitscage · 09/04/2026 13:55

I was taking mine orally, so gp doubled my prescription and I mostly take it half n half ie 1 tab orally , 1 vaginally… I find this works well as I get some sleep benefit from oral progesterone but the vaginal dose definitely means I’m getting enough to offset the 3-4 pumps of gel daily.

When I started mj, I discussed with gp and was firm I didn’t want to go back to patches as they didn’t work as well (had issues with them coming unstuck ). GP listened and was happy to prescribe double Utrogestan for as long as I was increasing doses… have reached maintenance now but as I feel great in current dosing, I don’t plan to change anything.

namechange0998776554799000 · 10/04/2026 21:14

I just switched to patches, they're working great for me

Seriestwo · 11/04/2026 00:51

What do you mean vaginal progesterone? I’ve been given vaginal oestrogen and progesterone tablets (and oestrogen soarwy) are you isn’t the tablets vaginally?

Clearingaspace · 12/04/2026 11:46

Yes, the progesterone i take are round in shape but a generic brand. My GP recommended that they could be taken vaginally but this is not described as a method of taking them on the box . It was mentioned up thread that they haven’t been trialled vaginally so I am not sure how people found this out 😆

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