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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Three weeks on MJ 2.5ml - no effect whatsoever? Really upset

82 replies

localnotail · 18/03/2026 07:32

Hi - so I have been on Mounjaro for three weeks now, 2.5ml - and, as title says, I feel no different in any way! I'm not a big eater anyway, though I'm obsessed with bread and sometimes eat too much of it, but my weight gain (25kg over 2-3 years) was mainly due to menopause and antidepressants. I walk a lot - average 10k steps a day - so I'm not inactive.

I had various other issues with extra weight, and failed many times to lose it through dieting, so after a lot of deliberations I decided to go on weight loss injections - especially as a lot of my friends done them, and were really happy.

So after starting it, and after being on MJ for three weeks now, I still feel hunger - I skip breakfast (I was advised that interval fasting works well with Mounjaro) and feel so hungry by lunch time I feel like I could pass out. In the evening, I feel hungry again. I have not lost even a bit of weight. I watch what I eat, I eat small portions and dont have sweets or bread.

Is this normal? I asked my med provider and they said my body is adjusting. But I was expecting to feel at least a little different? My friend says she felt no hunger at all. What is going on?? Will it get better or should I give up? I already got a next 2.5ml pen, so have to do it for at least another month...

OP posts:
PearlsTeapot · 20/03/2026 09:45

Go with a different provider. I recommend medicine marketplace, they’re very reliable.

bignewprinz · 20/03/2026 10:35

OP - not to be snarky but just because it does matter when dealing with meds....you are talking about 2.5mg not 2.5ml. You want 5mg not 5ml.

localnotail · 20/03/2026 13:26

bignewprinz · 20/03/2026 10:35

OP - not to be snarky but just because it does matter when dealing with meds....you are talking about 2.5mg not 2.5ml. You want 5mg not 5ml.

No, it's fine. And I was told that before! Just shows I'm not good with these things...

OP posts:
SilenceInside · 20/03/2026 14:00

@localnotail I currently use Swift Doctor who have been fine, I’ve also used Asda, Zava, Pharmacy2U, WePrescribe and Lloyds with no issues either.

MedExpress won’t swap your second 2.5mg pen that you have for a 5mg pen. It’s not a question of “changing the prescription”, you just need to get a 5mg pen from a new pharmacy.

Did MedExpress not send you any information at all about the typical dosing schedule? Anyway I suppose it doesn’t matter now. I think the dosing schedule is also explained in the paper leaflets that come with each pen.

Bubblyb00b · 20/03/2026 20:06

SilenceInside · 20/03/2026 14:00

@localnotail I currently use Swift Doctor who have been fine, I’ve also used Asda, Zava, Pharmacy2U, WePrescribe and Lloyds with no issues either.

MedExpress won’t swap your second 2.5mg pen that you have for a 5mg pen. It’s not a question of “changing the prescription”, you just need to get a 5mg pen from a new pharmacy.

Did MedExpress not send you any information at all about the typical dosing schedule? Anyway I suppose it doesn’t matter now. I think the dosing schedule is also explained in the paper leaflets that come with each pen.

Thank you. The leaflet might have had a schedule - but why did they allow me to get a smaller dose without even asking? I find it weird. If there is a set schedule, why even giving me an option?

I did not ask them to swap the pen, I asked to give me another 2.5 pen after two weeks so I can double dose with to get to 5mg. I haven't heard back yet.

With regards to going to another pharmacy - do I tell them already I have a 2.5 pen but need a higher dose? or not? What do I need to tell them - would they ask why I want to change?

Sorry - accidentally logged in with my old name )) I'm the OP

RoseField1 · 20/03/2026 20:15

Bubblyb00b · 20/03/2026 20:06

Thank you. The leaflet might have had a schedule - but why did they allow me to get a smaller dose without even asking? I find it weird. If there is a set schedule, why even giving me an option?

I did not ask them to swap the pen, I asked to give me another 2.5 pen after two weeks so I can double dose with to get to 5mg. I haven't heard back yet.

With regards to going to another pharmacy - do I tell them already I have a 2.5 pen but need a higher dose? or not? What do I need to tell them - would they ask why I want to change?

Sorry - accidentally logged in with my old name )) I'm the OP

Edited

Don't buy another 2.5, that's just wasting more money. It's up to the patient to decide if they want to increase the dose or stay the same. It's really up to you to inform yourself and decide. PP have already explained how you go about getting a 5mg pen from another pharmacy! Just register and order one: they will ask you qualifying questions and then prescribe it.

PearlsTeapot · 20/03/2026 20:37

OP with another pharmacy they'll want to see evidence of your first 2.5 pen in order to issue you a 5- a photo of the box with the prescription sticker will do.

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