Mounjaro seems less effective after six months, cravings and food noise back

[ArtfulRedhead]

Is it possible that mounjaro just isn’t working anymore?

I’ve been on it for six months and have slowly increased to 7.5mg. But whereas at the beginning I had the suppression and the food noise was gone, now I don’t feel anything at all. It’s almost as if I’m injecting water.

I don’t really want to increase anymore as I promised myself I’d stay as low as possible. Also the cost makes moving up further pretty impossible.

I'm just craving sugary rubbish all the time, constantly obsessing over food and the whole reason I wanted to be on mounjaro was for this to stop.

i know mounjaro won’t do all the work for me and I don’t expect it to, I want to use it alongside calorie counting as a tool to help stop the cravings and food noise but it’s not 😞😞

Sorry OP but I have to say a quick FFS.

Not at you personally but because I keep reading about people paralysed with (understandable) fear because they have read of horrors supposedly experienced by others.

I will repeat what I wrote only a few days ago to another person feeling the same as you are now.

For every person telling you how ill they were, how they nearly died/ stomach blew up/ head fell off etc there will be 99 saying bugger all because they have had no side effects at all.

Misery loves company and horror stories get attention. Who even knows if people are being honest and if they actually took the drug correctly?

Of course there is a risk of side effects, as there is from any drug.

There is also a risk from staying fat.

You weigh it up and make your choice but if you keep doing what you are doing you will keep getting what you are getting and it isn’t what you want.

Therefore you need to make a change or accept the current situation as it is.

I know five people in real life, plus myself, who have gone all the way to 15mg in gradual increases as prescribed and not one of us have had any side effects more than mild constipation which was easily managed with some extra fibre and lactulose.

Crack on to 10mg or give up and save your money.

Re side effects, I did get mild but unpleasant ones as I moved up - my sulphur burps were truly horrid. But they went. Everyone seems to have ‘their’ dose. I am not the fastest loser but lost most of my weight (5 stone plus) between 7.5 and 10. I actually moved up to 12.5 post Christmas to help get back on track and it was bloody pointless - lost barely anything but had guts like a cement mixer. Moved back to 10 and felt way better and started to lose again.

this week I did my bonus dose and there was a bit more than 10 in there. I have more side effects but feel hungrier. When I have check my tracker (I am a logger), my protein has been quite a bit lower than usual so aim for the rest of the week is to focus on that.

maybe do think re moving up (especially now if you take the bonus does before the pens change) but maybe click count to move up slowly? I have never just gone from one dose straight to another, always clicked my way up….

I had 9 st to lose. I followed the instructions on the packet assuming they were written in order for people to get maximum results from the medication. Therefore I went up 2.5mg every 4 weeks. I went from 19st to 10st between April 24 and March 25. I then titrated down and maintain on 5mg. Never had a single issue.

Sorry if you found it to be aggressive or patronising to respond in this way but I think if you are throwing money at this you don’t really have, then isn’t it in your favour to be honest with you about it but also its been a week and I agree it’s hard to make your own rules here when you can’t actually control your reaction to the medication so you might need a higher dose

But it’s not comparable to pain killers. It’s comparable to things like statins or blood pressure meds or diabetes meds, think about it logically, they would not be prescribing for things like diabetes or shortly cardio vascular disease, if ir wore off, it would be both risky and pointless. It would never be approved. No one gives meds for life threatening conditions that wear off and stop working.

in fact it’s the opposite these are recommended for life.

people are supposed to move up every four weeks to find their optimal dose. Which is the one below which you can’t tolerate. But you know when you get there.

but instead of following the advice, people mess around with dosing, try to stay on too low doses for too long due to cost them pop up and proclaim they stopped working, um. No, no they didn’t. They never do, and if done correctly everyone would know that.

it really is a case of fuck about and find out.

That sounds a good way to look at it.

Admittedly I've never gone up that high myself, but what you're describing is a drug that doesn't seem to be working for you any more and has higher dosages available. I do understand the financial issue, but it sounds like you're getting the worst of both worlds at the moment.