15mg & affects wearing off - what to do

[HeyDiddleDumplings]

I’ve been in mounjaro for over a year. I’ve lost slowly but consistently, never had side affects but needed to move up doses frequently. I’ve been on 15mg for about 3-4 months. The affects are really starting to wear off. I’m managing with exercise and paying a lot more attention to what I eat. However, I still have 3stone to loose.

Any recommendations for what I can do? I’ve considered jabbing a day early so every 6 days, or giving myself a bit more, so like 16mg. What have others done to help?

Maybe try a triple agonist, if you've never had any side effects, you possibly don't respond too well to mj, if you have another 3 stone to lose, and are already at 15.

I felt much the same as you last autumn and for unrelated reasons took a break from mounjaro of three weeks.
I then restarted on the same dose and it felt like it was working again.

Are you talking about retatrutide?

It is not licensed anywhere yet and not likely to be legally (and safely) available in the UK for another two years.

I have heard of some idiots buying what they are told is retatrutide from facebook, or a gym, or a beautician etc but clearly this is highly irresponsible and dangerous behaviour.

@HeyDiddleDumplings when you say you're paying more attention to what you eat, what is your actual calorie deficit? It doesn't matter how high your dose, if you're not in a calorie deficit, then you won't lose weight. MJ can help you with food noise but if you're eating the wrong stuff then it's still easy to go over on calories.
I wouldn't take a higher dose than 15mg every 7 days, in effect that's overdosing.

Go on, enlighten us how it is possible to safely get a drug that is not licensed in the uk and be confident of the quality controls, full supply chain and storage conditions…..

@HeyDiddleDumplings
I had this problem, after 9-10 months on 15mg it was no longer working effectively and I was not losing weight.
I spoke to my provide and they suggested reducing to 10mg for a month then 12.5 for a month then back to 15, I think the idea is that my body has got used to it and this might help to reset.

I am currently on my second week of 10mg. I was extremely hungry for the first week and it was difficult to make sensible decisions about food so I ate terribly.
This week I have been focusing on protein, fibre and water more and it has been better. I have gained a few pounds but not massive amounts.
I am hoping that if I can get used to 10mg over the next 2 weeks then when I move back up to 12.5mg I will feel a benefit and be able to reduce my food intake to allow me to lose weight again.

I am in the same predicament @HeyDiddleDumplings. From doing some research there seems to be a few options that others have tried.

Inject 15mg every 5 days. Apparently this is the same as taking 17.5mg every 7 days. Or just go up to 17.5mg every 7 days.

Personally I feel this could get (even more) expensive especially when the new 4 dose pens arrive. What if 17.5 doesn’t work. Would I go to 20mg or 25mg! I don’t know if I feel that different on 15mg than 12.5mg, so I doubt 17.5mg is going to be significantly better. I think for some of us it just doesn’t have a strong effect.

Some people take a break. Either missing up to 2 weeks then restarting on 15mg. Or taking a longer 6 week break and restarting on a lower dose. Both of these options seem to work for some. However others have found that it stops working altogether or they experience really bad side effects 2nd time around. Some manage to keep the weight off whilst taking a break but others pile it on.

I have decided to split my dose and take 7.5mg on a Tue and a Friday. I have only started this last week so too early to tell if it makes any difference. I have also cast a critical eye over my food intake both in terms of quality and quantity. Obviously my calories must be too high now that my weight is significantly less than when I started. Up to now I haven’t been strictly counting calories but have managed to be in deficit. At the moment I am maintaining my weight beautifully, just a shame I still need to drop about 2 stone.

Whatever you do, don’t start buying some unlicensed crap as suggested by @During off your hairdresser or online.

I've been at 15mg for about 8 months and after the first 2 months on it I only lost a few lbs over the next 6 months. I have recently stepped it up with really strict meal planning and calorie counting and have managed to lose 2lbs this month. I am trying to keep my calories below 1200 a day and am very focused on protein.

Don't increase your dose above 15 by jabbing early and don't try to find black market medication.
Your options are as far as I can see;

• increase protein and reduce carbs and sugar without reducing calories and see if that supports the effects of the medication
• reduce calories whilst doing the above
• take a short break for 2 weeks then resume on the same dose
• do the same as above but resume on a slightly lower dose
• reduce your dose slightly for 2 weeks then go back up again

I have tried most of those over the past 14 months and they are varyingly effective.

You are quoting the wrong person.

@During do you “happen” to know someone that is selling these unlicensed drugs and might be able to put mumsnetters in contact?

Maybe I am overly suspicious but you pop up, no posting history and want to persuade us we should buy illegal medicines which have not yet completed clinical trials.

I was on 15mg for approx 10 months (tritrating down now) but noticed I didn’t get the same effect after about 4 months. I switched to 8mm needles and noticed a marked difference, might be worth a try. There isn’t any evidence that backs this up (that I’m aware of) but really worked for me, and the bonus was that I stopped getting any irritation at the injection site.

Thanks all. There’s some helpful suggestions here. I have always needed to up my doses and needed a higher dose to loose weight. I can be stricter with calories for sure. I haven’t really needed to until now, although I do try to have a high protein & fibre first.
I won’t be ordering an unlicensed product on the black market - I wouldn’t even know how to 😆

interested in the idea of changing needles @Iwouldratherbesinging are they longer so go a bit further in? I’ve only ever injected into my tummy - so I could try thigh.

@Belindabelle dound alike we ar win quite a similar place. Doe taking it twice a week help you?

I’m the same. On 15mg. 18 months into my journey 7 ish stone lost with 2 to go.
I didn’t rush up the doses past 7.5mg & increased by 1.75mg when I felt the need to.
Been on 15mg for about 3 months & haven’t lost any weight since the New Year. The last few weeks especially I have felt food noise creeping back in & I have overeaten at times. Can eat bigger potions. You just know when the good effects are waning.
I just want to get to goal now after a long journey & getting a bit fed up.
Currently going through my options. Thinking of possibly injecting every 5/6 days whilst the bonus dose is still here & I have a small stockpile of pens or trying a different injection site, longer needles etc.
Also to start strength training.
I haven’t needed to reorder since August 25 but will need to in late June.
I will likely need to stay on some kind of GLP1 for maintenance but with no MJ golden dose I can’t justify paying like £66 per week for a 15mg pen. I can afford it but I don’t want to pay that much. Will stick with MJ until goal & then try Wegovy or even the pill if it is out by then.

@HeyDiddleDumplings I inject into my stomach as well, usually the needle caps that are supplied are 4mm in length, so yes the 8mm goes further in but doesn’t feel any different, I haven’t ever tried injecting in a different area though.

@HeyDiddleDumplingsnot really noticing any difference yet. I am feeling motivated to get on and lose the last bit so I am being extra vigilant with calories, protein etc.

I switched to wegovy for 3 months, then back to mj when it wore off because it wasn't good for my blood sugars like mj was and also inflammation and ibs symptoms returned in month 3. Switched back 3 weeks ago and I've been on a lower dose than before but it feels just as strong if not stronger. Others have said similar with using a lowe dose when returning so a break may help.

Obviously I'm not going to give out actual information to get retatrutide but yes carry on using the licensed drugs in a completely unlicensed manner, ffs the hypocrisy .

I don’t mess around, I take genuine, legally prescribed medication correctly as clinically advised by a medical professional and yes I think the fact that I buy it legally does give me the moral high ground to call out dangerous and illegal drug sales.

Mumsnet seems to agree because they deleted your post.

Op I think the further in it goes the less imoact it has, you can google but the 4 is optimal

it sounds like you want the drug to do the heavy lifting for you , and thay will never be a successful strategy as you need to keep it off. So I’d focus on cals now.

I agree and it really is all about the numbers.

Whilst the medication helps us eat less, unless you track your calories religiously and eat in deficit you won’t keep losing weight.

It is much easier at first and people find they lose initially without counting calories at all but that does not continue.

I use nutracheck and log every single thing I eat and drink. I don’t guesstimate but am precise in weighing portion sizes.

I can then predict if I will lose, maintain or gain on my weekly weigh in by looking at my weekly calorie total.

I would also add that TDEE is a guide and we all vary a bit. If I eat what my TDEE calculation advises to lose weight I actually just maintain so I had to reduce my daily allowance by another 150 calories. I think my metabolism is expecting an ice age!