Mounjaro Making Me Ill????

[zacsGranny]

I will try and keep this simple.
Started MJ in September prescribed by GP and Diabetes Centre for medical reasons. Supposedly closely supervised.
Went up from 2.5 to 5mg in October. Great weight loss and blood sugars. No side effects.
1st December started during the night with violent S & D with really bad wind. After 8 days I spoke to Diabetes Nurse and GP and was referred to Ambulatory Care at local hospital, worried about my kidneys and dehydration. Blood tests. Told it was a stomach virus, maybe Norovirus and to stop certain meds, including diabetes meds and MJ.
More trips to hospital for tests as diarrhoea continued. Couldn't eat.
Had to cancel Christmas and New Year as I thought I might pass it on.

By January felt a bit better so Diabetes Nurse did blood tests and said I could go back on 2.5 MJ. After a week, diarrhoea returned, with wind and a lot of pain.
Managed to see a Doctor at hospital as pain was so bad and I ended up on morphine. They diagnosed Diverticulitis and put me on antibiotics.
(I knew I had Divertticular, but had never had flare ups)
Ended up with impacted constipation from the painkillers and had to have two enemas.
Doctor at hospital prescribed laxatives.
After three days, back to diarrhoea, so severe, combined with wind and sickness, that I can't possibly go and sit in A & E where the waiting time is a minimum of 6 hours.Have not been able to eat for over two months. Feel very weak.
Was up all last night with the pain and I am so desperate for help that I have made an appointment at a private hospital to see a Gastroenterologist.
Is this the MJ or something else?

MJ sounds the obvious thing to try stopping and see what happens.

When I stopped the MJ, the symptoms tailed off slightly, but still continued. My Diabetes Nurse insisted on blood tests which cleared me to resume, so I assumed everything was OK.
It's not like I was buying privately. I was being medically supervised.
Does anyone know how long MJ stays in your system please?

Mj has a half life of 5 days. So counting jab day as day 1, by day 6 the level in your body reduces by half, and then by day 11 it halves again, by day 16 halves again etc

and, if you jab each week obviously levels rise again….

Eg in simple terms week 1 jab 2.5mg, day 6 levels approx 1.25, day 11 approx 0.625, day 16 0.3125

but if on day 8 you jab again, then levels compound so that day 11 will be around 1.75, day 13 around 1.6, day 15 jab again …..

you could use dose diary, Shotsy etc to enter your doses and get a fairly accurate prediction.

Poor you! That’s sounds really horrid for you and it sounds like your consultant appointment is the best next step to resolving this.

Do you keep a detailed diary of everything you’ve eaten? You could have developed an intolerance to particular foods that might have nothing to do with MJ or maybe MJ has triggered the change?

Dairy products used to give me horrific wind and diarrhoea. Weirdly, since being on MJ, I can drink full fat milk, eat butter, etc. and no bad after effects.

I have eaten very little since the beginning of December. Chicken, some veg. Eggs, scrambled or boiled or poached seem OK. I saw a Chinese Doctor who recommended Ginger tea and porridge and I can tolerate small amounts. Even water sets off stomach pain.
Only total starvation keeps me pain free.

It could be linked to the diverticulitis and mj slowing down food transit meaning food is being trapped in the diverticular pouches which is causing the side effects through irritation and inflammation of your colon. I'm a scientist team manager and dissect diverticular colons amd have seen some nasty infections and inflammation with them..and that was 3-5 years ago, before mj.

Totally anecdotal so could be completely irrelevant here but just to say that my DH gets really awful pain and vomiting & diarrhoea after eating eggs. He sometimes ends up lying on the bathroom floor for hours.

He can tolerate the occasional egg if it’s from our own flock (fed organically and they’re free range) but he tends to avoid all eggs now. He’s a fussy eater and has always eaten a very limited diet anyway and I don’t cook any meals for him.

He’s in his 70’s and this issue with eggs only started about 10 years ago.

Oh poor guy. I know how he feels.
I am so desperate, I have made an appointment to see a Consultant at a private hospital on Monday. The best the NHS can offer is a 6 hour wait in A & E. Not possible with my stomach problems. If it's as simple as that I've developed an allergy to something I'll be very happy. Also if I can just identify triggers. But things I can tolerate one day, seem to be triggers the next.
Its the sheer unpredictability of it that's so hard to deal wath, as well as the pain.

No idea. But I hope you feel better soon, sounds awful.

Apparently taking MJ etc with Diverticular / Diverticulitis is contraindicative but hasn't been picked by either my GP or Diabetes Nurse or the specialist Diabetes Centre I attend.
Will be interesting to see what the Consultant says.

Quick update for anyone interested.
I have Smoldering Diverticulitis, so nothing to do with MJ.
The Diverticulitis was diagnosed very late and badly managed by the NHS. I was given the wrong antibiotics and laxatives and badly advised.
I had to pay for a private prescription and meds and he is writing to my GP recommending another scan and possibly surgery after the infection is cleared up.
It's certainly a load off my mind.

I'm glad you're feeling better

So you started this medication already having diverticulitis?

No, I had diverticular, but had never had a flare up in 10 years. I was prescribed MJ after consultations with my GP and a specialist Diabetes Centre because of a complex medical history.