Spacing out the doses

[fancytoes]

Anyone had any luck spacing out the doses? I’m now officially at target.

I went to a private doctor for a flu jab who asked for a full histology and he was singing Mounjaro’s praises. He said start spacing out the doses eventually ending up at 1 week a month etc. I was in a bit of a rush and didn’t think to ask about the shelf life etc.

I’m pretty cavalier about that as they’re kept in the fridge and I already have experience of making pen last 7-8 weeks which worked well.

Scales said 8st 13.8lbs this morning but I don’t want to go lower as I need to choose face over body now!

Starting weight, 12.6stone in June 2025 and I have three 5mg in the fridge.

Personally it’s not for me, I don’t want the mediation to be fully put my system them start again, or very big peaks and troughs, I maintain on a low dose of 5mg, I had 10mg as my optimal dose in weight loss phase.

I can see this an an economical way for some people to maintain, having a boost, perhaps a week of suppression out of 3 could be a good option. the only issue would be that pharmacies seem to have to tighten up processes so someone would end up with stockpile as they would be forced to order more than required

I'm titrating down the doses from 15mg, my next dose will be 5mg. I inject every 10 days and take the golden dose. The pen is kept in the fridge and I always use the alcohol pad and clean needles. I'm aware of the infection risks and try to mitigate as much as possible.

My plan is to slowly titrate down to the lowest possible dose. Spacing out a higher dose would mean you would peak and trough I would have thought. There may be reasons why that might be better but I’d want to understand why first.

That's contrary to everything I've read or been told by my doctor. You want to keep your dosage as smooth and level as possible. Taking it one week a month will just mean you spike for one week and then you may as well not be taking it at all. If you microdose once a week then you will have it working the whole month. Three weeks out of four if you use his method, you're effectively without a working dose.

I cannot see how that would ever be a good idea for all the obvious reasons, does this flu jab Dr specialise in the area of GLP1s or was he just being curious and it was an off the cuff uninformed opinion? (sounds very much like the latter).

Not something I would act on.

It would make more sense to dose weekly with much smaller doses than just once a month.

I wouldn't space it out, just use a really low dose, I am only on 2.5 still as my main dose so eventually I will just use less clicks. I am currently using a 5mg pen as assumed I needed to go up in month 2 as recommended it but I cant handle higher doses. I get 9/10 doses from the pen. When I reduce I will probably have to buy 2.5 pens as not sure it is ok to use for 18-20 weeks with open pen.

Why would the doctor ask for histology? That's tests done on tissue I.e. cutting up tissue and staining, I've worked in histology for 20+ years. Do you mean full blood tests so haematology?
As for the doses I've made my way down from 15mg to 7.5mg and will continue tapering down before extending time between doses to avoid peaks and lows which can increase side effects and then leave you struggling with hunger depending on how you manage with lower doses.

@Mysticmaiden i thought the same. I suspect the OP meant full history.

I've got a friend at work who doses once a month for maintenance and feels like it's working for her 🤷

Full medical history, sorry was typing without my glasses earlier! I also just wanted a quick bloody flu fab and ended up with a long consult about family medical history etc! Possibly an overzealous central London private practice?

I thought it rather odd as well so was wondering anyone else had been told something similar. I’m going to jab every 9-10 days as I haven’t been feeling like I need it every 7 and have often left it to 8 so will have due to circumstance.

I’m specifically after views or experience from anyone else doing this long of a gap between doses.

I do 5mg every 2 weeks and have been for 2 months now. So far I’ve maintained my weight (9st 12lbs) and I’m happy with that. Good job cause my BMI (20.2) is too low to be able to order more from my supplier. I’ve got a surplus of 1 year in the fridge from 5mg to 15mg pens.

This is interesting, since losing a lot of weight and getting very low bmi, I'm trying to work out what works maintenance wise, I've been going two weeks between small doses and reading this it seems I might be better doing every week, I'm on tirzepatide 2.5 every two weeks gonna try 1.25 every week

I’m at maintenance and currently going as long as I feel comfortable (dosing either 5mg or 3.75mg), I did 5mg 11 days ago and 3.75mg today. My aim is to get to 2.5mg for 10 days as slowly as I need to

I don't think you will find anyone doing this as it's a ridiculous theory. The med doesn't last for 3 weeks in the bloodstream.

Yes it does.

Well yes it takes 25- 30 days to come out your system fully as the half life is 5 days, so it’s 5 half lives.

this means every five days there is 50 percent less. So after the second half life although technically it’s in there there will be absolutely no impact as the amount will be tiny,

so as it’s a month she’d need to take 2.5mg to avoid getting unwell. After five days she’s only got 1.25 in her system, after ten she’s only got 0.625, after 15 it’s only 0.31, after 20 it’s 0.156, after 25 it’s 0.0078.

so where as technically yes it’s in your system for all intents and purposes there is nothing there, nothing that would have any impact so I agree with the poster it is a ridiculous idea,

I’ve done similar , but it’s a right the pain when comes to re ordering as the suppliers really don’t like it !!

I do one shot of 2.5 about once every 3 weeks and have done for about a year and have maintained target weight. I have a stockpile in my fridge. (Edited for typo)

As i said in my pp, whilst it isnt something I'd do, personally I would take a low dose each week, there are posters who have said it works for them, the numbers you quoted would be if you took it for the first time also so not quite right.

It makes no sense to me to do it, 2.5 was strong for me so if I took it once a month it would probably make me ill, probably not at first as obviously its built up in your system but after a while, for the reasons you have said, I would probably end up getting all the side effects

if you a gap of a month then it’s pretty much the same as first time, even three weeks, it’s why the manufacturers say go back to the start. The numbers are absolutely correct.

Ok, thats fine, Shotsy app may well be wrong then. Either way, it clearly works for some in whatever way, for me it wouldn't, I couldnt even manage 3.75 after 5 weeks on 2.5.

I inject a 2.5 dose every ten days and have done for the last four months. I don’t feel any more hunger than injecting every seven days. I do still have a couple of stone to lose so will stay like this and then see what works for me to maintain. I think I will try a smaller dose rather than spreading out days.

shotsy is not wrong, I just did it and it says the exact same thing, as it would as factually the med has a five day half life, and if you don’t inject for three or four weeks then there is no more medicine being added in, it is physically impossible to have more in your system.

maybe you’re putting in the wrong data.