Mounjaro and low mood/feeling nothing?

[Sunshinesash]

Hi there

ive read of lots of people who feel amazing on Mounjaro with their mood and it’s life changing. For me, I started last March and was on mounjaro til December. Lost 3.5stone and honestly it was great loss however my mood was definitely low on it.

i lost all enjoyment of food and even hobbies/shows anything that I previously enjoyed. I wouldn’t say depression but definitely a feeling of numb I suppose.

I came off to see if it would help and I do feel better, enjoying food and starting to slowly feel happier but I have regained. I’m hoping to restart and going to stay low at 2.5mg… does anyone have any similar experience and do you think the 2.5mg may be okay for me to try again?

Such a double edged sword!

Yes it had some weird mood side effects for me. I have very recently stopped taking it.

I was actually quite emotionally all over the place too. I cried and felt overwhelmed a lot. It made Me a little unstable emotionally. I also lost the ability to orgasm! A side effect that isn’t talked about too much.

I am thinking about starting to micro dose after giving my body a little break. I have two health conditions that cause inflammation as a side effect and pain and swelling is starting to return in my body.

It does this to me too, total flatness. Makes the world gray-scale...though I am definitely not depressed, I am just meh about everything. You could offer me 2 weeks free at a 5 star in the Maldives and I wouldn't be arsed to go. Also, yes to pp, it also affects my ability to orgasm, not that it matters because who can't be bothered to shag on this drug? 😁

I am sorry to say I never went over 2.5mg, so it affects my dopamine profoundly even at that dose. I've seen some theorize that it's the lack of comfort eating that affects mood rather than the drug, but I never took comfort in food, so that doesn't ring true for me. I just had terrible portion control.

I hate being negative about MJ, so I will end this post by saying I am in the best physical shape in years, and I think the drug is amazing. So many health markers inmproved for me! I am starting to titrate off because of the anhedonia, but I am also concerned about weight gain. So I may end up having to compromise.

This is one of many issues I'm having

and I've only lost 10lb in two months

probably going to come off but I've got three doses left - it sounds silly but when you pay so much for it, you don't want to waste it. Don't know what to do.

Yes my friend was very meh on it so came off it once at target. She is normally very bubbly. She is back to normal now, gained a stone back though

'Only' lost 10lb in 2 months? That's solid weightloss. I'd be very happy with that.

I've lost about 1lb a week on average. I've been on it 7 months though.

Definitely had the same. Real anhedonia - lack of interest and joy in lots of things. Improved massively since decreasing to a maintenance dose 🙂

I have a more positive story. Started last April - lost 3.5 stone - only went up to 5mg. Was very flat on 5mg though. Exhausted. Hardly able to exercise. Just miserable. Got to goal in August. Went down to 3.75mg and kept losing so went to 3.75mg every 2nd wk. It was like someone flipped a switch. All my energy came back. I am suddenly addicted to running. Getting up at 5am to run 10k before cycling to work. Totally back to my old self but with the body I always wanted! I’m now maintaining on 2.5mg every 2 wks. Was still losing slowly on this before Xmas so will probably continue to titrate down… I plan to stop after the summer when I’ve been at goal for a year but also I know I’m fine on a low dose so if I need to take a maintained dose I will.

I would definitely try 2.5mg and see how you get on. I lost about 1.5 stone on it. Good luck.

I had this when I went up to 10mg from 7.5. It was so marked, so strong. I wanted to quit my job, couldn’t see the point of going on holiday etc. thought about coming off altogether but instead I went down to 5mg, then slowly back up to 7.5 and felt normal again. I’m not moving from here, it was awful.

Thanks for all of this. It really positive to hear some of you have found lower doses helping. I stayed on 2.5 for a very long time as it really was quite effective for me though by the end of the year I was up to 7.5. I think I’ll definitely give 2.5 another go, I feel better off of it but I am definitely gaining again so want to try and stick to 2.5 and see if I can slowly lose/maintain and keep enough energy to get a good excercise routine going

Wish I was one of those who just felt amazing on it though, it’s been tricky to navigate the feeling of numbness even when things in life are going great!

Op, where do you get your dopamine hits from when it’s not food? You need to replace it.

Yes, I have experienced dopamine blunting since being on Mounjaro but I have also experienced high level work stress, started HRT and lost a parent so it's a combination of all those factors. I really focused on building dopamine seeking into daily life through small methods such as listening to music with an emotional swell, wearing fragrance every day and burning scented candles, taking baths, regular walks when the sun was out, watching comfort shows on the TV, making my living space nice and I definitely feel it has improved my mood. I considered seeking antidepressants not because of Mounjaro but the whole picture but over the past few months of working on my happy hormones I feel I have got over the worst of it. I would rather be blunted than revert to seeking dopamine from food if I'm honest and looking at myself in my new clothes and in my underwear in the mirror is also a bit of a dopamine boost

Just found this thread as I was looking for relatable experiences. I’ve been on the jabs just over 2 months, lost over a stone and am just in the healthy BMI range (all good right?).

However I’m struggling with fatigue and lack of energy - I actually like exercising but seriously cba at the moment. And I’ve realised I feel quite flat or even down (resulting in me being even grumpier than usual with my husband).

None of my clothes fit so I feel quite scruffy. Slowly trying to replace them but it’s expensive I don’t have the time/ motivation to go shopping for bras etc.
I look in the mirror and I look slim (even good?) but I’ve realised that it’s true that your size is the least interesting thing about you! I also think I look older.

I could stop here with the jabs but am scared of regaining quickly (I have a sweet tooth) and also have fear of not being able to get hold of MJ again!

I did 1 month on 2.5mg (main symptom constipation) then went up to 5mg (constipation went but had a horrible dry mouth and generally felt like crap) so after 3 weeks dropped it back to 3.75mg. I’ve done 2 weeks on that, the difficult poos are back. I'm thinking about going back down to 2.5 and seeing if things settle symptom and mood wise but I quite like @Incognitoburrito88idea of taking it every 2 weeks. I just want some spark back.

I definitely felt a change in my mood about the 2nd day each week after injection . It took a couple of months for me to realise the connection.
By day 4 ok again.
I now delay my injection by the oddday if i have anything planned that needs full focus etc

I tried it, i really had horrendous anxiety to the point i waa extremly concerned about my sanity. Never again.

I had a mildish version of this, I think on 10mg or 12.5mg. I have no idea whether they're linked but I started taking iron tablets and a multivitamin and it lifted.

I've also since reached goal and am tapering down and I'm full of beans now

I think I experience this for the first 1-2 days at least. I am on 5mg but wonder if I should drop back to 2.5. I am losing slowly but the weekends are a washout because I jab on a Friday. In fact I'm glad you started this thread because I wasn't sure if I was the problem.