Inflammation- why does it return if we have lost the weight?

[MrsMiagi]

Does anyone know why inflammation returns if you stop taking MJ, even when you have lost the weight?
Also, how would I know it was inflammation in the first place? I asumed everything was fat lol.
The hair loss is so bad I am thinking about stopping for a while but do I need to give myself a buffer if inflammation will come back?

I’ve just experienced exactly this this week.
MJ took away 40 years worth of osteoarthritis pain literally overnight and I have been leaping out of bed pain free for the past 18 months.
Then this week I delayed injecting for a week and have been feeling crippled, having to sit down with ibuprofen and a drink and wait 30 mins before being able to walk painfree.
Also post menopausal dry eyes have come back with a vengeance in the same sudden timescale.
I had forgotten just how painful life was all the time pre-MJ until it suddenly now recurred.
Interesting for me that the pain and inflammation stopped so suddenly on starting MJ, within days and before I had even lost any weight.
Waiting now to see what happens…

Op, no drug works when you don’t take it. It is not a life time cure that you take for a bit then that’s you done.

however a pp said she has osteoarthritis, and we need to differentiate between people with known conditions like this and people who do not.

my view is that some people do not focus on protecting muscle during the weight loss phase. Muscle is active and burns calories. Fat is not. If you loss a lot of muscle, then your bmr drops significantly. So when you come off you can eat at lot less. A lot less. Before you start regaining. In addition fluid comes back likely due to increased carbs, salt etc.

so I think people with conditions, then if you’re not medicated it will come back, if you don’t have a condition, then it is likely fluid and, if you lost a lot of muscle, weight gain as your bmr dropped and now you simply can’t eat a lot.

Well, because the drug reduces inflammation? I noticed it within the first couple of doses, when I hadn’t lost any weight at all. I was smaller, in no pain, and my brain fog went. No weight had been shifted yet.

Thats really interesting, to feel a difference so quickly. My pain is still there and I have lost 5 stones so I think for me, there hasn't been a change like there has been for people like yourself who felt it within a few doses.

This I do know and understand.... I learned the hard way from years of yoyo dieting. Its the inflammation aspect I find fascinating because I naively thought with weight loss would come some relief.

So op, how do you know it was inflammation and not just water retention due to excess weight, blood sugar etc?

Also I read a report on one of the trials.

basically as we go through life, our cells suffer damage, colds, flus, viruses,lifestyle ie alcohol, fatty foods etc, injuries, and as much as we recover, our cells always carry that marker, they never fully recover, they are forever damaged, and that damage is in effect inflammation, whuch accumulates over time, and stops the cells fully regenerating.

this is what ageing is, it is the cumulative effect of damage we sustain, which is seen as inflammation and thus preventing regeneration fully.

the drugs reduce inflammation, this allows the cells in our bodies to regenerate, when the inflammation goes, the cells regenerate, the inflammation prevents it happening fully and the older we get, the more inflammation we have as it’s accumulated, and the less our cells can regenerate.

this has an anti ageing effect, which is different on different people. Some people it stops ageing, others it actually reverses it. The medication keeps the inflammation away. Allowing our cells to regenerate.

not our skin or faces, that’s collagen, but our internal organs basically.

If you stop the meds, then thar inflammation returns if you’ve a condition that causes it, ie arthritis, or if your lifestyle causes it, or if you’ve not been on the meds very long so your cells have only minorly regenerated, so the damage is still there, and no medication controlling the inflammation, stopping the drugs allows it to return as our cells are damaged due to all the health issues we have faced over a lifetime.

they are now going into trials for fhe anti ageing effect of the drugs, again this is not aesthetics, but internally.

Thank you for this, great explanation and makes so much sense.

Have you cut out wheat and sugar op? These are very inflammatory.

Because the symptoms of inflammation have gone - in my case joint pain, brain fog, butterfly rash, dry (unopenable) eyes.

I learnt (on one of the Zoe food science podcasts) that there are beneficial bacteria that only start to proliferate once the last bit of food has passed through the bowel. These bacteria are especially beneficial because they "eat" the lining of the gut, causing it to self repair and become less likely to leak causing inflammation. After consuming the frayed bits of the gut wall they excrete short chain fatty acids that are needed to bind to particles that would otherwise trigger inflammation, mopping them up. The same short chain fatty acids also effect the brain, improving mood and sleep quality, and the circulatory system, as well as a shedload of other processes. They are the reason why having a healthy gut microbiome improves your general health.

It takes between 10 and 14 hours after a meal for the food eaten to pass through the bowel. So people like me, (who would eat supper before bed and then breakfast as soon as they get up) never allow those bacteria to do their job properly. Leading to a build up of inflammation particles, which in turn have triggered Hashimoto's thyroiditis, Sjogren's syndrome, Rheumatoid Arthritis, Lupus and type to diabetes (in my case).

I was really cross when I realised that I would be in a lot less pain if I'd just known about the importance of having a 16 hour fast every day. As well as "feeding" the beneficial gut bugs with loads of soluble fibre and cutting out all the UPF ingredients that weaken and kill them.

Since hearing that podcast and adding small portions of kimchi, kombucha, sauerkraut and kefir to my daily diet I have lost 89kg (14 stone?) since March 2022. Effortlessly for the first 18 months, and then with the aid of mounjaro once I was no longer morbidly obese.

Once I get down to a normal BMI and waist to height ratio I will stop buying the private prescription, but continue taking the 5mg pen until a better drug becomes available. (Losing another 4kg will bring me into the healthy BMI range, but I currently still have 14cm to go before my waist is less than half my height).

Amazing!