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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Unsure what to do next

10 replies

Thischarmlessgirl · 31/10/2025 20:51

Hello,

I started Mounjaro early July. I’ve been on 2.5mg the whole time and lost 10kg in 18 weeks. BMI now 27 (pcos) and my once high hbac is now well within normal. My clothes feel better and I’m definitely more confident in how I look.

My weight has plateaued for the last couple of weeks and I feel I should probably go up to 5 mg, however what I’ve really noticed also over the last six weeks is that my mood is very low and I’m tearful a lot, plus my hair is really shedding to the point I’m worried about it.

I’m taking lots of supplements and trying to eat plenty of protein. I am lifting weights twice a week but finding motivation increasingly difficult.

I feel really unsure as to whether to stop completely and hope that my mood improves and my hair starts to grow back, or to push on with 5 mg and try and get to my goal weight, or just below before coming off and seeing how I get on.

Milo mood is really quite noticeable, and I’m finding it hard to get motivated. I don’t usually suffer with depression and I am a mental health professional so know that this isn’t usual for me.

would appreciate any shared experiences or advice.

OP posts:
Mysticmaiden · 31/10/2025 22:17

I've been on MJ for a year and from the start had low mood and poor motivation. I believe it's due to the dopamine disruption. I've also lost a lot of hair too. I eat plenty of protein, collagen and vitamins but I do have to eat low calories to lose due to my height, age and weight. L tyrosine has helped with the low dopamine and you can buy it from amazon.

Orangesandlemons77 · 01/11/2025 01:38

I'm also around the same BMI and using my remaining pens with a low dose to hopefully avoid the side effects and lose weight gradually.

Ilovebabykangaroo · 01/11/2025 04:43

Don’t go up to 5mg.

Because of the reasons you have listed, I have titrated up very slowly, I have been on it 1 year, have lost 4.5 stone (28.5 kg) and still have not reached 5mg.

Personally, I would go up to 2.8mg.
If you are using 2.5 pen that is 60 clicks then another 1 click
If you are using 5mg pen then it is 34 clicks.

this is interesting reading about plateauing….

https://www.secondnature.io/guides/mind/motivation/weight-loss-plateaus-explained

Weight-loss plateaus explained | Weight loss tips

Have you reached a 'stalemate' on your weight loss journey, despite keeping up healthy habits? Learn why this happens and what it means for weight loss.

https://www.secondnature.io/guides/mind/motivation/weight-loss-plateaus-explained

StrongLikeMamma · 01/11/2025 07:53

Would L tyrosine combat what the glp1 is doing at all?

Thischarmlessgirl · 01/11/2025 08:24

Thanks - I’m already taking LTyrosine supplements (for the last two months) but no noticeable improvement in mood.

OP posts:
blackwhitepink · 01/11/2025 08:34

Plateaus are normal and not always a sign to move up. I have done a year at 2.5mg and ridden out a couple. What you are eating is much more important than the dose so if you are finding you cannot manage to eat in a healthy calorie deficit that would be when to consider moving up. That said, if it was affecting my mood in a negative way like you say there is no way I would continue taking it.

Freecall · 01/11/2025 09:48

Ilovebabykangaroo · 01/11/2025 04:43

Don’t go up to 5mg.

Because of the reasons you have listed, I have titrated up very slowly, I have been on it 1 year, have lost 4.5 stone (28.5 kg) and still have not reached 5mg.

Personally, I would go up to 2.8mg.
If you are using 2.5 pen that is 60 clicks then another 1 click
If you are using 5mg pen then it is 34 clicks.

this is interesting reading about plateauing….

https://www.secondnature.io/guides/mind/motivation/weight-loss-plateaus-explained

I think your arithmetic is a bit off there.

2.8mg from a 2.5mg pen is 0.68ml (or as you phrased it - 60 clicks plus another 8 clicks)

Ilovebabykangaroo · 01/11/2025 10:34

Freecall · 01/11/2025 09:48

I think your arithmetic is a bit off there.

2.8mg from a 2.5mg pen is 0.68ml (or as you phrased it - 60 clicks plus another 8 clicks)

Edited

Yes, you are correct, it is 8,

Mysticmaiden · 01/11/2025 14:42

StrongLikeMamma · 01/11/2025 07:53

Would L tyrosine combat what the glp1 is doing at all?

No its an amino acid that increases dopamine. I've lost 5.3lbs this month at a bmi of 22.8 9st 2.8lbs so whatever I'm doing is working! I do high protein low carb and add collagen, liquid vitamins and liquid iron to my morning protein shake. It really works for my mood and I have way more energy than before I did this.
OP try creatine as that's also a good energy source for body and brain.

Orangesandlemons77 · 01/11/2025 16:47

Funny to see all the Oushk ads throughout this post, didn't realise they were being promoted on here!

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